What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

Yeral, İlkin; Sayan, Cemile Dayangan; Karaca, Gökhan; Şimşek, Yavuz; Sağsöz, Nevin; Ozkan, Zehra Sema; Atasoy, Pınar; Şahin, Yusuf; Neşeli̇oğlu, Salim; Erel, Özcan

doi:10.1111/jog.13876

Cited by 7 publications

(5 citation statements)

References 31 publications

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“…In a study conducted by Yeral et al [6], it was determined that there was no significant difference in the number of pre-antral + antral and total follicles between the groups with and without albumin treatment after 3 hours of ischemia and 7 days of reperfusion.…”

Section: Discussionmentioning

confidence: 97%

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Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

et al. 2019

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Objectives: The aim of this study was to compare the effects of sildenafil, vardenafil and tadalafil in treatment for ischemia/reperfusion injury which is created experimentally in rat ovaries. Material and methods: For this study, 30 female Wistar albino rats were used, and the rats were separated randomly into five groups consisting of six rats each: normal, torsion-detorsion, torsion-detorsion + sildenafil 1.4 mg/kg, torsion-detorsion + vardenafil 1.7 mg/kg and torsion-detorsion + tadalafil 5.0 mg/kg. The agents were given intraperitoneally 30 minutes before detorsion. An ovarian torsion procedure was implemented in all other groups for 3 hours with the exception of the normal group. Then, a detorsion procedure was implemented to the groups for 3 hours. Results: The sildenafil and vardenafil treatments showed protective effect by preventing significant increase in inflammation parameters. (p = 0.058, 0.138). The tadalafil treatment was only protective for cellular degeneration (p = 0.140). The vardenafil treatment was protective for edema (p = 0.238), vascular congestion (p = 0.111), inflammation (p = 0.138) and cellular degeneration (p = 0.532). Sildenafil, vardenafil and tadalafil inhibited the increase of atretic follicle. AMH levels were statistically different between torsion and detorsion and vardenafil group (p = 0.004, 0.004), whereas tadalafil and sildenafil groups were similar to normal group (p = 0.108, 0.108). Conclusions: PDE inhibitors were found to be effective in reducing ovarian ischemia/reperfusion injury. Sildenafil and tadalafil seem to be more effective than the vardenafil in protecting the ovarian reserve.

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Section: Discussionmentioning

confidence: 97%

“…When ovarian damage occurs; follicular reserves decrease, infertility and early menopause risk increases [5]. Ovarian reserves can be assessed by serum markers or follicle counts [6].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

et al. 2019

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“…The GII and GIII groups were given oral 500 mg/kg krill oil (Krilom® ultra krill oil, Tabilaç, Turkey) for seven days (Yeral et al 2019). While 80 mg/kg gentamicin was administered subcutaneously to the GII for 7 days, physiological isotonic saline was administered subcutaneously to the GIII.…”

Section: Animal Experimental Protocolmentioning

confidence: 99%

Protective effect of krill oil against gentamicin-induced oxidative stress-mediated nephrotoxicity in rats

Şahin¹,

Alçığır²,

Şenol³

et al. 2022

Kocatepe Veterinary Journal

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This study aimed to evaluate the protective effect of krill oil against nephrotoxicity caused by gentamicin. Distilled water was given orally to the control and second groups (GI) for seven days while 500 mg/kg krill oil was given to the third (GII), fourth (GIII) groups. In addition, isotonic saline was administered subcutaneously to the control and GIII groups throughout the study, while 80 mg/kg gentamicin was administered to the GI, and GII groups. Alanine aminotransferase (ALT) and gamma glutamyltransferase (GGT) peptidase, total cholesterol, urea, and creatinine levels in plasma and, malondialdehyde (MDA) and total antioxidant status (TAS) levels in both plasma and kidney tissue supernatant were evaluated. Histopathological changes in tubules and glomeruli and vascular changes were evaluated by scoring. Urea level and ALT activity were found to be significantly lower in the GII and GIII groups compared to the GI group (p<0.001; p≤0.001). As a result, it was observed that degenerative damage and glomerular changes in the tubule at the histological level mediated by oxidative stress were consistent with the increase in ALT, urea, and MDA levels. In this respect, it is suggested that krill oil can be used as a nephroprotective food supplement to contribute to treatment in cases of toxicity.

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“…However, reperfusion after detorsion of the ovary can be also hazardous because of neutrophil infiltration and excessive production of reactive oxygen species (ROS), called ischemia–reperfusion injury 3 . Pharmacologic conditioning with different drugs, having antioxidant and anti‐inflammatory properties, has been investigated to test their preventive effect on ischemia–reperfusion injury 4–8 …”

Section: Introductionmentioning

confidence: 99%

Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress

Kalyoncu

Yılmaz

Demır

et al. 2020

J of Obstet and Gynaecol

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Aim: To investigate the protective effect of octreotide and lanreotide on ovarian damage in experimental ovarian ischemia-reperfusion injury. Methods: Fifty-six rats were separated into seven groups; group 1: sham group, group 2: surgical control group with 3-h torsion and detorsion, group 3: 0.02 mg/kg s.c. octreotide 30 min before 3-h torsion, group 4; octreotide just after detorsion for 7 days, group 5: octreotide 30 min before torsion and just after detorsion for 7 days, group 6: single time 20 mg/kg s.c. lanreotide before torsion, group 7: single time lanreotide just after detorsion. Results: All histopathological scores except congestion were significantly lower in group 1 than other groups. In addition, hemorrhage (group 2 vs 4: P < 0.05), degeneration (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.01 and group 2 vs 6: P < 0.05) and total damage score (group 2 vs 4: P < 0.05, group 2 vs 5: P < 0.05, group 2 vs 6: P < 0.05 and group 2 vs 7: P < 0.05) were significantly lower than other groups. Moreover, ovarian tissue total oxidant status and oxidative stress index levels were significantly decreased in groups 5 (both P < 0.05) and 7 (both P < 0.05) when compared to group 2. Furthermore, tissue levels of peroxynitrite were significantly higher in group 2 than groups 1, 3 and 5 (all P < 0.05). Conclusions: Octreotide and lanreotide have a protective role against ischemia-reperfusion damage in rat torsion detorsion model by improving histopathological and biochemical findings including tissue levels of total oxidant status, oxidative stress index and peroxynitrite.

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What is the protective effect of krill oil on rat ovary against ischemia–reperfusion injury?

Cited by 7 publications

References 31 publications

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

Comparison of the protective effects of sildenafil, vardenafil and tadalafil treatments in ischemia-reperfusion injury in rat ovary

Protective effect of krill oil against gentamicin-induced oxidative stress-mediated nephrotoxicity in rats

Octreotide and lanreotide decrease ovarian ischemia–reperfusion injury in rats by improving oxidative and nitrosative stress

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