What is the significance of pancreatic ductal mucinous hyperplasia?

Allen-Mersh, T G

doi:10.1136/gut.26.8.825

Cited by 18 publications

(3 citation statements)

References 16 publications

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“…These changes promote the formation of intraluminal protein gel or plugs, which are early histological features of chronic pancreatitis [78]. Intraductal obstruction can lead to pancreatic atrophy, ductal mucinous hyperplasia [79, 80], Goblet-cell metaplasia and perhaps pancreatic stone formation [77]. …”

Section: Cftr Dysfunction In Pancreatitismentioning

confidence: 99%

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

Hegyi

Wilschanski

Muallem

et al. 2016

Reviews of Physiology, Biochemistry and Pharmacology

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Cystic fibrosis transmembrane conductance regulator (CFTR) is an ion channel that conducts chloride and bicarbonate ions across epithelial cell membranes. Mutations in the CFTR gene diminish the ion channel function and lead to impaired epithelial fluid transport in multiple organs such as the lung and the pancreas resulting in cystic fibrosis. Heterozygous carriers of CFTR mutations do not develop cystic fibrosis but exhibit increased risk for pancreatitis and associated pancreatic damage characterized by elevated mucus levels, fibrosis and cyst formation. Importantly, recent studies demonstrated that pancreatitis causing insults, such as alcohol, smoking or bile acids strongly inhibit CFTR function. Furthermore, human studies showed reduced levels of CFTR expression and function in all forms of pancreatitis. These findings indicate that impairment of CFTR is critical in the development of pancreatitis; therefore, correcting CFTR function could be the first specific therapy in pancreatitis. In this review, we summarize recent advances in the field and discuss new possibilities for the treatment of pancreatitis.

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Section: Cftr Dysfunction In Pancreatitismentioning

confidence: 99%

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

Hegyi

Wilschanski

Muallem

et al. 2016

Reviews of Physiology, Biochemistry and Pharmacology

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“…In our study, the prevalence rates of PanINs fell within these ranges. In contrast, the prevalence rates of PanIN‐1 and PanIN‐3 in patients without pancreatic adenocarcinoma ranged from 15.5% to 82% and from 0% to 3.4%, respectively . There was no difference in the frequency of PanIN‐1 between patients with and without invasive ductal carcinoma.…”

Section: Discussionmentioning

confidence: 79%

“…Many studies have reported on the frequency of PanIN lesions in patients with or without invasive ductal carcinoma . However, there have been no reports about the relationship between PanIN in invasive ductal carcinoma and prognosis.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor

et al. 2014

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The mucus-hypersecreting tumor of the pancreas. Development and extension visualized by three-dimensional computerized mapping

Furukawa

Takahashi

Kobari

et al. 1992

Cancer

143

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Background. Mucus‐hypersecreting tumor of the pancreas appears as dilated ducts and cystic spaces filled with mucus. To determine where such tumors arise and how they extend, computer‐aided three‐dimensional reconstruction was done of the ductal system. This also was used to visualize the spatial relationships among epithelial hyperplasia, dysplasia, and carcinoma in situ (CIS). Methods. Surgically removed pancreases were studied from 12 patients with mucus‐hypersecreting tumors. The specimens were fixed in buffered formaldehyde solution lo%, embedded in paraffin and semiserially sectioned at 3 pm at an interval of 60 pm. The ductal contours were diffentiated among ducts lined by ordinary epithelia, hyperplastic epithelia, dysplastic cells, or CIS and were inputted into a computer system that integrated a three‐dimensional image of ducts in the display. Results and Conclusions. (1) The tumors arose in the main pancreatic duct or its subbranches, and the cysts corresponded to segments expanded by the superficial growth of tumor cells; (2) areas of CIS arose in zones of preceding dysplasia, suggesting a dysplasia‐carcinoma sequence; and (3) dysplastic or cancerous cells often extended intraductally over the dilated segments of ducts.

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What is the significance of pancreatic ductal mucinous hyperplasia?

Cited by 18 publications

References 16 publications

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis

Pancreatic intraepithelial neoplasia in the background of invasive ductal carcinoma of the pancreas as a prognostic factor

The mucus-hypersecreting tumor of the pancreas. Development and extension visualized by three-dimensional computerized mapping

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