What is the underlying cause of type II diabetes? – Are cells protecting themselves against the reactivity of glucose?

Dalgaard, Jacob Z.

doi:10.1016/j.mehy.2017.06.011

Cited by 3 publications

(4 citation statements)

References 63 publications

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“…Various theories have been reported to identify the reasons behind the disturbance in glucose homeostasis resulting in increased blood glucose, insulin level, and HbA1c, and consequently the development of diabetes (120). This includes environmental factors, a stressful life, sleep deprivation, and genetic factors (121,122).…”

Section: Importance Of Fasting In Reversing the Pathogenesis Of Type 2 Diabetes And The Need For Studies In Childrenmentioning

confidence: 99%

“…This includes environmental factors, a stressful life, sleep deprivation, and genetic factors (121,122). However, it has been shown that this epidemic rise is strongly related to a substantial alteration in diet or lifestyle in general, where people tend to consume a great amount of processed foods, fast foods, and refined sugars (120). Dalgaard (120) has proposed that cells are protecting themselves from the high level of glucose by shutting off the glucose uptake to prevent any cellular damage that could take place due to autocatalytic glycation.…”

Section: Importance Of Fasting In Reversing the Pathogenesis Of Type 2 Diabetes And The Need For Studies In Childrenmentioning

confidence: 99%

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Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

Elmajnoun

Faris

Uday³

et al. 2021

Front. Nutr.

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Background: The world is still struggling to control the COVID-19 pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The level of uncertainty regarding the virus is still significantly high. The virus behaves differently in children and young adults. Most children and adolescents are either asymptomatic or have mild symptoms. They generally have a very good prognosis. However, it is not well-known whether children and young adults with type 2 diabetes are at risk of getting a severe infection of COVID-19. Many Muslim children with type 2 diabetes have been performing dawn to dusk fasting during the month of Ramadan, before and during the COVID-19 pandemic, and the impact of this on their health has not been well investigated. Previous studies in adults have suggested that intermittent fasting may be beneficial in different ways including reversal of type 2 diabetes and prevention of COVID-19 infection.Objective: The primary aim of this narrative review is to summarise the impacts of the COVID-19 pandemic on children and young adults with type 2 diabetes, and to identify the knowledge gaps in the literature. It also explores the potential of intermittent fasting in reversing the pathogenesis of diabetes and highlighting how this approach could prevent these patients from developing chronic complications.Methods: This narrative review has been produced by examining several databases, including Google Scholar, Research Gate, PubMed, Cochrane Library, MEDLINE (EBSCO), and Web of Science. The most common search terms used were “COVID-19 AND Children”, “SARS-CoV-2 AND/OR Children”, “COVID-19 AND Diabetes” “COVID-19 Epidemiology”, “COVID-19 AND Ramadan fasting”, “COVID-19 and Intermittent fasting.” All the resources used are either peer-reviewed articles/reports and/or official websites of various media, governmental and educational organisations.Results: Having reviewed the currently limited evidence, it has been found that the incidence of COVID-19 among children with type 2 diabetes seems to be not much different from children without diabetes. However, these patients are still vulnerable to any infection. Several studies have reported that prevention programmes such as intermittent fasting are effective to protect these groups of patients from developing any complications. Moreover, observing Ramadan fasting as a type of intermittent fasting could be beneficial for some children with established diabetes, prediabetes and people at risk.Conclusion: Children and young adults with type 2 diabetes are not at risk of severe COVID-19 infection as the case in adults with diabetes. More research is needed to identify the impact of COVID-19 and to investigate the efficacy and safety of intermittent fasting, including Ramadan fasting, among these age groups. Implementing these cost-effective programmes may have a great impact in minimising the incidence of diabetes. Moreover, this could be effective particularly at prediabetes stage by preventing these people from going onto develop type 2 diabetes and taking medications for the rest of their life and protecting people from complications linked to disease and infection.

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Section: Importance Of Fasting In Reversing the Pathogenesis Of Type 2 Diabetes And The Need For Studies In Childrenmentioning

confidence: 99%

Section: Importance Of Fasting In Reversing the Pathogenesis Of Type 2 Diabetes And The Need For Studies In Childrenmentioning

confidence: 99%

Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

Elmajnoun

Faris

Uday³

et al. 2021

Front. Nutr.

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show abstract

“…Importantly, starvation or low-calorie diets might not only have a positive effect on nerve-regeneration, but also on the metabolic and functional states of the nerve-cells: Firstly, type-two diabetes has recently been proposed to be caused by cells protecting themselves against the damaging effects of inter-cellular high-glucose levels; or put a different manner type-two diabetes is due to silencing of genes involved in the uptake and metabolism of glucose [2]. Here it is important to note, that glucose is the main energy source of the nerve-cells; even more so than other tissues.…”

Section: Mini Reviewmentioning

confidence: 99%

“…Interestingly, diabetes has also been associated with a greater incidence of dementia, and one possibility is that in this tissue, silencing of genes involved in uptake and metabolism of glucose might be directly be related to the progression of dementia [3]. Importantly, several studies suggest that low-calorie diets can be employed to revert type II diabetes patients blood-sugar levels to normal [4,5], potentially by resetting the transcriptional program of the genes involved in the uptake and metabolism of glucose [2]. Thus, in this connection, it is worth mentioning that in doing so these lowcalorie diets might also prevent the mental decline associated with diabetes.…”

Section: Mini Reviewmentioning

confidence: 99%

Why Low-Calorie Diets Might be Good for Your Brain in More Than One Way?

Dalgaard¹

2017

CTBEB

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Chaos, mitochondria and type 2 diabetes; does type 2 diabetes arise from a metabolic dysrhythmia?

Baskerville

2019

Medical Hypotheses

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What is the underlying cause of type II diabetes? – Are cells protecting themselves against the reactivity of glucose?

Cited by 3 publications

References 63 publications

Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

Impact of COVID-19 on Children and Young Adults With Type 2 Diabetes: A Narrative Review With Emphasis on the Potential of Intermittent Fasting as a Preventive Strategy

Why Low-Calorie Diets Might be Good for Your Brain in More Than One Way?

Chaos, mitochondria and type 2 diabetes; does type 2 diabetes arise from a metabolic dysrhythmia?

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