What is Vestibular Papillomatosis? A Study of Its Prevalence, Aetiology, and Natural History

Welch, Jan; Nayagam, Maria; Parry, Graham; Das, Robert; Campbell, Meg; Whatley, J D; Bradbeer, Caroline

doi:10.1097/00006254-199406000-00018

Cited by 10 publications

(14 citation statements)

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“…These assumptions are in part derived from the colposcopic observation of aceto‐whitening of vulva and microscopic findings of koilocytes in the biopsy specimens, incriminating HPV infection as those occurring in the cervical epithelium. Clinicopathologic correlations in these patients were further supported by the demonstration of HPV antigens and/or HPV DNA using immunohistochemical 23,25,26,45 and molecular‐based techniques, 19–21,23,24,27,29,32–34,36–45 respectively.…”

Section: Discussionmentioning

confidence: 95%

“…‘HPV vulvitis’ describes a putative clinical disorder characterized by local symptoms of burning, pruritus, pain and/or dyspareunia, evidence of HPV infection by clinical, colposcopic and/or histologic examination and no other explainable causes 18–47 . The spectrum of clinical findings in HPV vulvitis includes vestibular or vulvar squamous papillomatosis (VSP), vulvar erythema (VE) and/or acetowhite regions of vulva.…”

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confidence: 99%

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‘HPV vulvitis’ revisited: frequent and persistent detection of novel epidermodysplasia verruciformis‐associated HPV genotypes

Lin

Rohwedder

Mysliborski³

et al. 2007

J Cutan Pathol

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Section: Discussionmentioning

confidence: 95%

mentioning

confidence: 99%

‘HPV vulvitis’ revisited: frequent and persistent detection of novel epidermodysplasia verruciformis‐associated HPV genotypes

Lin

Rohwedder

Mysliborski³

et al. 2007

J Cutan Pathol

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“…We wish therefore to call attention to this frequent (allegedly presented by 1% of women) 6 but often ignored entity in order to reach correct diagnoses and avoid repeated and unnecessary treatments of normal genital anatomic variants.…”

Section: Discussionmentioning

confidence: 99%

Vestibular papillae of the vulva

2004

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“…Vulvar vestibulitis with varying degrees of vestibular erythema and localised tenderness confined to the vulvar vestibule is recognised as one of the major causes of vulvar pain 1 . Vestibular papillomatosis 2–4 and vulvar human papillomavirus (HPV) infection 5 have also been related to vulvar complaints. However, it is uncertain whether vulvar vestibulitis, vestibular papillomatosis and HPV infection of the vulva can be held responsible for vulvar complaints since these findings have not been examined in women without vulvar complaints.…”

Section: Introductionmentioning

confidence: 99%

Normal findings in vulvar examination and vulvoscopy

Beurden

Vange

Craen

et al. 1997

BJOG

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Objective To determine the normal vulvar findings by naked eye examination and by vulvoscopy in Design Observational study. Population Forty healthy volunteers without vulvar complaints recruited via a newspaper advertisement.Methods Vulvar examination, human papillomavirus (HPV) polymerase chain reaction of vulvar and cervical swabs, saline and KOH smears and vulvoscopy before and after the application of 5% acetic acid. Main outcome measuresPrevalence of vestibular erythema, vestibular papillomatosis, HPV infection on the vulva and in the cervix and vulvoscopic findings. ResultsThe mean age of the women was 37.8 years (median 38.0, range 21-56). Nine women were current smokers and 2 1 had previously smoked. Naked eye vulvar examination showed vestibular papillomatosis in 13 women (33%) and vestibular erythema in 17 women (43%). The touch test was positive in 9 of the 17 women (53%) with vestibular erythema. Vulvoscopy after the application of acetic acid 5% showed an acetowhite vestibule in all women. Twelve women (30%) had acetowhite lesions outside the vestibule. Six women (15%) were positive for HPV DNA. The presence of HPV DNA did not correlate with vestibular erythema or vestibular papillomatosis. There was a weak association between HPV DNA and acetowhite lesions outside the vestibule ( P = 0.055, Fisher's exact test). In this group the younger women significantly more often had vestibular papillomatosis (t-statistic = 3.07; P = 0.003) and women who smoke more often had a genital HPV infection ( P = 0.016, Fisher's exact test).Conclusions Vestibular erythema, vestibular papillomatosis, and acetowhite lesions are common in this group of healthy women without vulvar complaints.healthy women without vulvar complaints. and has been used in the management of vulvar intraepithelial neoplasia (VIN) to remove all visible lesions8-l0. The colposcope was introduced in the evaluation of abnormal cervical cytology because the colposcopic image has been proven reliable in the prediction of histological alterationsll. Although the classification of vulvoscopically visible lesions is the same as the one used for colpo~copy'~, it is uncertain whether vulvoscopy has the same predictive value as colposcopy. This is mainly because the normal distribution of vulvoscopic findings has not been determined in women without vulvar complaints and therefore one cannot distinguish between physiology and pathology. INTRODUCTIONThe aim of this study was to determine the normal vulvar findings by naked eye examination and by vulvoscopy in healthy women without vulvar complaints to obtain a reference value for vulvar examination 320 0 RCOG 1997 British Journal of Obstetrics and Gynaecologyand vulvoscopy in the diagnostic work-up of women with vulvar complaints. METHODSVolunteers were recruited via an advertisement in a national newspaper. They were eligible if they were between 20 and 60 years old, if they were healthy and if they did not have vulvar pruritus, vulvodynia, dyspareunia or known vulvar abnormalities. The approval for this...

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What is Vestibular Papillomatosis? A Study of Its Prevalence, Aetiology, and Natural History

Cited by 10 publications

References 0 publications

‘HPV vulvitis’ revisited: frequent and persistent detection of novel epidermodysplasia verruciformis‐associated HPV genotypes

‘HPV vulvitis’ revisited: frequent and persistent detection of novel epidermodysplasia verruciformis‐associated HPV genotypes

Vestibular papillae of the vulva

Normal findings in vulvar examination and vulvoscopy

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