What Makes a Faller in Early Parkinsonism?

Charlett, André; Weller, C.; Sm, Dobbs; Rj, Dobbs

doi:10.1159/000113401

Cited by 5 publications

(3 citation statements)

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“…The reported fall incidence in PD patients ranges from 33 to 68% [2,9,22,41]. Fractures, particularly in the femoral neck, are among the most devastating complications of falling in patients with PD [16,21].…”

Section: Introductionmentioning

confidence: 99%

Balance confidence and functional mobility are independently associated with falls in people with Parkinson’s disease

2009

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The present study aimed to examine the association of falls with self-perceived balance confidence level, and balance and mobility performance in patients with Parkinson's disease (PD). Forty-nine healthy subjects and 71 subjects with PD completed the study. Among the PD patients, 33 (46%) were fallers and 38 were non-fallers. All subjects were tested with the activities-specific balance confidence scale (ABC), one-leg-stance test (OLS), and timed-up-and-go test (TUG). Results indicated that PD fallers had significantly lower ABC scores, shorter OLS times and longer times to complete TUG than PD non-fallers (P < 0.05). Having a high ABC score (>80) was significantly associated with a lower fall risk, after adjusting for age, gender, and duration of PD, and for depression [odds ratio (OR) = 0.06, P = 0.020]. For performance-based measures of balance and mobility, a longer TUG time (> or =16 s) was independently associated with increased risk of falling after controlling for relevant factors (OR = 3.86, P = 0.043); OLS time, however, was not significantly associated with falls. A lower self-perceived balance confidence level and a prolonged time to complete TUG were associated with increased risk of falling in patients with PD. Interventions to improve these modifiable risk factors could be useful in reducing future falls in the PD population and will require further study.

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Section: Introductionmentioning

confidence: 99%

Balance confidence and functional mobility are independently associated with falls in people with Parkinson’s disease

2009

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“…The few retrospective studies have shown an increased risk of falling in PD. [18][19][20][21] The problem with looking retrospectively at falls is that elderly patients may forget they have fallen. [22][23][24] In this study we therefore investigated the baseline characteristics of a cohort of community dwelling patients with PD and assessed the incidence of falls prospectively over a one year period.…”

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confidence: 99%

Incidence and prediction of falls in Parkinson's disease: a prospective multidisciplinary study

Wood¹,

Bilclough²,

Bowron³

et al. 2002

Journal of Neurology, Neurosurgery &Amp; Psychiatry

594

459

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Objectives: To accurately establish the incidence of falls in Parkinson's disease (PD) and to investigate predictive risk factors for fallers from baseline data. Methods: 109 subjects with idiopathic PD diagnosed according to the brain bank criteria underwent a multidisciplinary baseline assessment comprising demographic and historical data, disease specific rating scales, physiotherapy assessment, tests of visual, cardiovascular and autonomic function, and bone densitometry. Patients were then prospectively followed up for one year using weekly prepaid postcards along with telephone follow up. Results: Falls occurred in 68.3% of the subjects. Previous falls, disease duration, dementia, and loss of arm swing were independent predictors of falling. There were also significant associations between disease severity, balance impairment, depression, and falling. Conclusions: Falls are a common problem in PD and some of the major risk factors are potentially modifiable. There is a need for future studies to look at interventions to prevent falls in PD.

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“…В некоторых исследованиях было показано, что провоспалительные агенты, такие как интерлейкин 1β (ИЛ1β), ИЛ6, ИЛ8, ИЛ10, ИЛ13, фактор некроза опухоли α (ФНОα), эйкозаноиды, белки острой фазы, ассоциированные с хроническими заболеваниями ЖКТ (например, язвенный колит) и изменениями микробиоты кишечника, такими как СИБР и инфекция Helicobacter pylori, также играют важную роль в развитии нейродегенеративных заболеваний, включая БП [34][35][36].…”

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The gut microbiome as a factor in the development of Parkinson's disease

Brsikyan

Poluektova

Полуэктов

2023

RJTAO

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Болезнь Паркинсона (БП) -мультифакториальное нейродегенеративное заболевание, которое начинается задолго до постановки диагноза, вовлекает в процесс различные нейроанатомические области, является результатом взаимодействия генетических факторов и факторов окружающей среды, а также начинается с широкого спектра симптомов. Так называемые «немоторные симптомы», такие как депрессия, когнитивные нарушения, автономные и сенсорные дисфункции, также входят в клиническую картину этого заболевания.БП является наиболее распространенным расстройством движения, встречается с частотой один-два человека на 1000 населения. Морфологически наряду с гибелью до-фаминергических нейронов в компактной части черной субстанции БП также характеризуется синуклеинопатиейнакоплением в нейронах нерастворимых полимеров денатурированного α-синуклеина вместе с токсичными субстратами паркина, называемыми тельцами Леви [1]. Плотность телец Леви коррелирует с выраженностью нейродегенерации и нейрональной гибелью [2].Несмотря на то что моторные симптомы по-прежнему считаются главными признаками БП, ранним проявлениям нарушения других функций уделяется значительное внимание, поскольку они рассматриваются как индикатор факторов риска, которые приводят к заболеванию, либо как биомаркер, являющийся объективной мерой для выявления О Б З О Р Ы 90

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What Makes a Faller in Early Parkinsonism?

Cited by 5 publications

References 0 publications

Balance confidence and functional mobility are independently associated with falls in people with Parkinson’s disease

Balance confidence and functional mobility are independently associated with falls in people with Parkinson’s disease

Incidence and prediction of falls in Parkinson's disease: a prospective multidisciplinary study

The gut microbiome as a factor in the development of Parkinson's disease

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