What makes cancer stem cell markers different?

Karsten, Uwe; Goletz, Steffen

doi:10.1186/2193-1801-2-301

Cited by 117 publications

(104 citation statements)

References 108 publications

(161 reference statements)

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“…In the past few decades, stem cell biology has provided new approaches and research into cancer biology. 25 It is now believed that tumor cells have the stem cell properties of selfrenewal and differentiation to generate mature cells. These cells are called cancer stem cells (CSCs), which have the ability to produce distinct cell types that are found in their original tumor (Flow Chart 1).…”

Section: Cancer Stem Cellsmentioning

confidence: 99%

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Cancer Stem Cells and Its Therapeutic Application: An Overview

Dash¹,

Dash²,

Rajguru³

2016

IJPCDR

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Section: Cancer Stem Cellsmentioning

confidence: 99%

“…24 There are many other noncarbohydrate stem cell markers, which are also CSC markers, such as Bmi1, CD29, CD44, CD90, CD117, Nestin. 25 Natural compounds, such as salinomycin, curcumin, sulforaphane have also been found in recent years to have the ability to kill CSCs.…”

Section: Cancer Stem Cells and Therapeutic Approachmentioning

confidence: 99%

Cancer Stem Cells and Its Therapeutic Application: An Overview

Dash¹,

Dash²,

Rajguru³

2016

IJPCDR

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“…CSCs are cells that have the capacity of self-renewal, meaning they undergo asymmetric divisions to produce more CSCs and a variety of differentiated daughter cells forming the bulk of tumor [13]. The translational definition of CSCs and the gold standard for exhibiting 'stemness' in CSCs is the ability to regenerate primary tumor in immune compromised mice.…”

Section: Cancer Stem Cellsmentioning

confidence: 99%

Stem Cells and Cancer

Ali¹

2016

J Cell Sci Ther

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Stem cells are undifferentiated cells that can differentiate into specialized cell and can divide to produce more stem cells. The concept of cancer stem cells has been discussed in the scientific literature since the 19th century. Circumstantial evidence suggests that most tumors are heterogeneous and contain a small population of cancer stem cells that exhibit distinctive self-renewal, proliferation and differentiation capabilities, which are believed to play a crucial role in tumor progression, drug resistance, recurrence and metastasis in multiple malignancies. Unlike normal adult stem cells that remain constant in number, cancer stem cells can increase in number as tumors grow, and give rise to progeny that can be both locally invasive and colonize distant sites-the two hallmarks of malignancy. Rapid advances in the cancer stem cell field have provided cause for optimism for the development of more reliable cancer therapies in the future. Strategies aimed at efficient targeting of cancer stem cells are becoming important for monitoring the progress of cancer therapy and for evaluating new therapeutic approaches.

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“…These results empower the CSC model of cancer initiation and its similarity to normal stem cell model. Although recently a considerable effort has been invested in the detection and characterization of stem cell markers and steadily increasing number of such marker molecules have been identified, most of these markers are lineage-specific rather than being tissue-specific (55). In this regard, markers that distinguish totipotent stem cells are nearly similar between different tissues.…”

Section: Screening Several Cancers Simultaneously Applying Csc Markersmentioning

confidence: 99%

Cancer Stem Cell’s Potential Clinical Implications

Mirzaei¹,

Madjd²,

Kadijani³

et al. 2017

Iran J Cancer Prev

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Context: To date, CSCs have been identified in a variety of hematopoietic and solid tumors. Applying CSC in clinical implication still depends on future studies to remove complexities including CSC heterogeneity and CSC similarity to normal stem cells. However, several potential clinical applications including therapeutic, diagnostic and prognostic implications have been introduced for cancer stem cells (CSC). In this review, we discuss previously considered and unconsidered potential clinical application of CSCs including how CSCs could be applied for pan-specific cancer screening and therapy. Evidence Acquisition: We will first discuss the previously proposed CSC clinical implications using a brief review of the literature. Subsequently, we will discuss some theoretical potential CSC implications which have not been discussed before including panspecific cancer screening and therapy, and present confirmatory references for each part of our hypothesis. Results: We hypothetically demonstrated the presence of similar markers in the CSC subset of different tumors and introduced it as a way to simultaneously screen several cancers using one CSC marker. Conclusions: Simultaneous screening of several cancers applying one CSC marker could be regarded as a novel high-value costconscious cancer screening approach which might evolve cancer screening concept. However, this application remains to be explored in the future instigations.

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What makes cancer stem cell markers different?

Cited by 117 publications

References 108 publications

Cancer Stem Cells and Its Therapeutic Application: An Overview

Cancer Stem Cells and Its Therapeutic Application: An Overview

Stem Cells and Cancer

Cancer Stem Cell’s Potential Clinical Implications

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