Land-use frontiers are territories with abundant land for agriculture and forestry, availability of natural resources relative to labor or capital and predisposed to rapid land-use change, often driven by large-scale land investments and capitalized actors, producing commodities for distal markets. Strategic spatial planning (SSP) represents a consolidated long-term governance practice across high-and low-income countries. One of the objectives of SSP processes is to articulate a more coherent and future-oriented spatial logic for the sustainability of land-use patterns and typologies, natural-resources protection, and investments. SSP may thus constitute a useful approach in addressing some of the challenges affecting land governance in frontier settings; to date, its potential contribution to land-use frontiers lacks explicit exploration. In this paper, we examine how SSP can play a role in governing land-use frontiers through a case-study analysis of Mozambique as an emerging frontier, located on the southeast coast of Africa. We gathered empirical evidence by interviewing experts involved in resource management, territorial planning, and development in the country. The theoretical spine of the paper builds on the literature focusing on land-use challenges and SSP. We show that emerging land-use frontiers face several challenges, such as transnational land deals and the intensification of commercial plantations. Interview data show that several structural factors are hindering the establishment of a long-term territorial development strategy. These are, among others, the short-termism of political cycles and the absence of a long-term strategic vision. Our analysis reveals that SSP processes could contribute to addressing land-use challenges in frontier contexts, such as poverty traps and land degradation spirals, should various local and distant actors join forces and marry interests. We conclude by presenting a systematic rationale, explaining how SSP could play a role in governing land-use frontiers, with a view to promoting the well-being and sustainability of rural communities.