What recent primary studies tell us about ovarian teratomas in children: a scoping review

Łuczak, Justyna; Bagłaj, Maciej; Dryjański, Piotr

doi:10.1007/s10555-020-09844-3

Cited by 8 publications

(7 citation statements)

References 41 publications

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“…As the EFS curve did not show any plateau, it suggests the need for prolonged surveillance after surgery 18,28 . Despite the lack of guidelines regarding the FU after OMT resection in children, and considering the median time to a second event of 30.5 months, we suggest a pelvic and abdominal US exam every 6 months during the 5 years following initial surgery.…”

Section: Discussionmentioning

confidence: 83%

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Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian‐sparing surgery

Delehaye

Sarnacki

Orbach

et al. 2021

Pediatric Blood & Cancer

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Background Ovarian mature teratoma (OMT) is a common ovarian tumor found in the pediatric population. In 10%–20% of cases, OMT occurs as multiple synchronous or metachronous lesions on ipsi‐ or contralateral ovaries. Ovarian‐sparing surgery (OSS) is recommended to preserve fertility, but total oophorectomy (TO) is still performed. Design This study reviews the clinical data of patients with OMT, and analyzes risk factors for second events. A national retrospective review of girls under 18 years of age with OMTs was performed. Data on clinical features, imaging, laboratory studies, surgical reports, second events and their management were retrieved. Results Overall, 350 children were included. Eighteen patients (5%) presented with a synchronous bilateral form at diagnosis. Surgery was performed by laparotomy (85%) and laparoscopy (15%). OSS and TO were performed in 59% and 41% of cases, respectively. Perioperative tumor rupture occurred in 23 cases, independently of the surgical approach. Twenty‐nine second events occurred (8.3%) in a median time of 30.5 months from diagnosis (ipsilateral: eight cases including one malignant tumor; contralateral: 18 cases; both ovaries: three cases). A large palpable mass, bilateral forms, at diagnosis and perioperative rupture had a statistical impact on the risk of second event, whereas the type of surgery or approach did not. Conclusion This study is a plea in favor of OSS as the first‐choice treatment of OMT when possible. Close follow‐up during the first 5 years is mandatory considering the risk of 8.3% of second events, especially in cases with risk factors.

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Section: Discussionmentioning

confidence: 83%

“…Information on the management of second events and long‐term morbidity was also retrieved through the reports of the postoperative consultations where abdominal ultrasound (US) was carried out. In the absence of consensus in the literature, the schedule of this follow‐up (FU) program differed from one center to another 17–19 …”

Section: Methodsmentioning

confidence: 99%

Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian‐sparing surgery

Delehaye

Sarnacki

Orbach

et al. 2021

Pediatric Blood & Cancer

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show abstract

“…As the EFS curve did not show any plateau, it suggests the need for prolonged surveillance after surgery (18). Considering the median time to a second event of 30.5 months and the slow growth rate of this benign tumor, we propose a pelvic and abdominal US exam every 6 months during the five years following initial surgery.…”

Section: Discussionmentioning

confidence: 96%

“…Information on the management of second events and long-term morbidity was also retrieved through the reports of the postoperative consultations where abdominal ultrasound was carried out. In the absence of consensus in the literature (17)(18)(19), the schedule of this follow-up (FU) program differed from one center to another.…”

Section: Populationmentioning

confidence: 99%

Lessons From a Large Nationwide Study of 350 Children With Ovarian Mature Teratoma: A Plea for Ovarian-Sparing Surgery

Delehaye

Sarnacki²,

Orbach

et al. 2021

Preprint

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Objective Ovarian mature teratoma (OMT) is a common ovarian tumor found in the pediatric population. In 10% to 20% of cases, OMT occurs as multiple synchronous or metachronous lesions on ipsi- or contralateral ovaries. Ovarian sparing surgery (OSS) is recommended to preserve fertility, but total oophorectomy (TO) is still performed. This study reviews the clinical data of patients with OMT, and analyzes risk factors for second events. Design A retrospective review of all girls under 18 years of age with OMTs was performed. Data on clinical features, imaging, laboratory studies, surgical reports, follow-up second events and their management were retrieved. Results Overall, 350 children were identified. Eighteen patients (5%) presented with a synchronous bilateral form at diagnosis. Surgery was performed by laparotomy (85%) and laparoscopy (15%). OSS and TO were performed in 59% and 41% of cases respectively. Perioperative tumor rupture occurred in 23 cases, independently of the surgical approach. Twenty-nine second events occurred (8.3%) in a median time of 30.5 months from diagnosis (ipsilateral: 8 cases including one malignant tumor, contralateral: 18 cases, both ovaries: 3 cases). A large palpable mass, bilateral forms at diagnosis and perioperative rupture had a statistical impact on the risk of second event, whereas type of surgery or approach did not. Conclusion This study is a plea in favor of OSS as the first choice of treatment of OMT when possible. Close follow-up during the first five years is mandatory considering the risk of 8.3% of second events especially in cases with risk factors.

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“…The role of oophoropexy in treating ovarian torsion is still not clear (2, 9, 11). evidence based medicine for pediatric ovarian teratomas (6). The other systematic review reported by Renaud et al also has revealed lack of prospective and randomized trials (1).…”

Section: Discussionmentioning

confidence: 99%

Bilateral Mature Ovarian Teratoma with Torsion in a Premenarchal Girl

Lešková

Kříž

Štichhauer

2022

Acta Med. (Hradec Kralove, Czech Repub.)

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Mature cystic teratoma is the most common type of ovarian tumor in children. Adnexal torsion is the main complication of mature ovarian teratoma. The synchronous bilateral incidence of mature cystic teratoma in premenarchal girls is known to be rare. However, the incidence of adnexal torsion is higher in young girls. A 10-year-old girl presenting with acute abdomen was managed by emergency laparotomy. Bilateral mature ovarian teratoma with adnexal torsion of the right ovary was found. The right ovarian tissue was not viable due to torsion and an oophorectomy was necessary. Cystectomy with preservation of the ovarian tissue of the left ovary was performed. Histopathological diagnosis was bilateral synchronous mature teratoma with necrosis of the right adnexa. Although the risk of malignancy of torsed ovaries and mature teratomas in premenarchal girls is low, their removal is recommended to prevent adnexal torsion. Decision between ovarian tissue sparing surgery or oophorectomy depends on the risk of malignancy, fertility preservation and the avoidance of early menopause.

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What recent primary studies tell us about ovarian teratomas in children: a scoping review

Cited by 8 publications

References 41 publications

Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian‐sparing surgery

Lessons from a large nationwide cohort of 350 children with ovarian mature teratoma: A study in favor of ovarian‐sparing surgery

Lessons From a Large Nationwide Study of 350 Children With Ovarian Mature Teratoma: A Plea for Ovarian-Sparing Surgery

Bilateral Mature Ovarian Teratoma with Torsion in a Premenarchal Girl

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