What's Race Got to Do With It? CRP Levels in Immune Mediated Skin Diseases: Considerations for Hidradenitis Suppurativa

Okeke, Chidubem A V; Williams, Jonathan P.; Iwuala, Callyn U.; Igwe, Pearl K.; Khanna, Raveena; Perry, Jessica D.; Okoye, Ginette A.; Byrd, Angel S.

doi:10.3389/fimmu.2022.847050

Cited by 2 publications

(3 citation statements)

References 41 publications

(30 reference statements)

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“…Expectedly, our findings demonstrated that the clinical efficacy of AG + AE was observably better than that of AG alone. As previously described, the increase in CRP levels helps predict whether patients are resistant to antidepressant therapy 41 . Interestingly, the initial findings of our study revealed that serum levels of CRP in remitters and responders were diminished after treatment with AG or AG + AE, but not significantly in nonresponders, suggesting that serum CRP levels were lower in both remitters and responders than those in nonresponders.…”

Section: Discussionsupporting

confidence: 73%

“…As previously described, the increase in CRP levels helps predict whether patients are resistant to antidepressant therapy. 41 Interestingly, the initial findings of our study revealed that serum levels of CRP in remitters and responders were diminished after treatment with AG or AG + AE, but not significantly in nonresponders, suggesting that serum CRP levels were lower in both remitters and responders than those in nonresponders. As a result, it was reasonable to conclude that the efficacy of AG + AE in MSD patients was related to serum CRP levels.…”

Section: Discussionmentioning

confidence: 54%

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Changes of Serum C-Reactive Protein Level in Patients With Depressive Disorders After Treatment With Agomelatine Combined With Aerobic Exercise and Its Significance

Sun,

Chen,

Zhang

et al. 2023

Clin Neuropharm

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Objective Depressive disorders constitute a series of debilitating diseases. This study investigated the therapeutic effect of agomelatine (AG) combined with aerobic exercise (AE) on patients with moderate-severe depression (MSD) and the changes of the serum C-reactive protein (CRP) level in patients after treatment as well as its significance. Methods A total of 178 MSD patients were randomly assigned to the AG group (N = 90) and AG + AE group (N = 88). The severity of depressive disorders and anhedonia was assessed using the Hamilton Rating Scale for Depression (HAM-D), Beck Depression Inventory, and Snaith-Hamilton Pleasure Scale scores. The serum CRP level in MSD patients was detected by turbidity assay. Patients were defined as remitters, responders, and nonresponders according to the HAM-D17 score, and the treatment efficacy was analyzed, followed by evaluation of the serum CRP level in patients with different treatment responses. Finally, the adverse reactions of patients during treatment were statistically analyzed. Results After treatment, the HAM-D, Beck Depression Inventory, and Snaith-Hamilton Pleasure Scale scores and the serum CRP level of the 2 groups were reduced, and changes in the AG + AE group was more significant than that in the AG group. The clinical efficacy of the AG + AE group was better than that of the AG group. After treatment, the serum levels of CRP in remitters and responders were reduced, but not significantly in nonresponders. The incidence of adverse events in the AG + AE group was lower than that in the AG group. Conclusion AG + AE reduced the serum level of CRP in MSD patients and had good therapeutic effects on MSD patients.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 54%

Changes of Serum C-Reactive Protein Level in Patients With Depressive Disorders After Treatment With Agomelatine Combined With Aerobic Exercise and Its Significance

Sun,

Chen,

Zhang

et al. 2023

Clin Neuropharm

View full text Add to dashboard Cite

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“…Despite the above, racial and ethnic differences are minimally represented in HS randomized controlled trials. It is imperative that physicians and researchers promote racial/ethnic diversity during patient recruitment [ 38 , 39 , 40 ].…”

Section: Hs and Race/ethnicitymentioning

confidence: 99%

Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits

et al. 2022

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Hidradenitis suppurativa (HS) is a debilitating, chronic, inflammatory skin disease primarily affecting apocrine gland-rich areas of the body. On the one hand, the presence of triggering factors—some identified, others only hypothesized—may initiate or perpetuate the pathogenic process of HS. In addition to cigarette smoking and diet, other trigger factors, including choice of clothing, are frequently observed in clinical practice. On the other hand, the presence of disease may influence habits of HS patients. Indeed, high incidences of sexual and sleep impairment have been reported in these patients. Consequently, alcohol and substance abuse may be a coping strategy for the emotional and psychological disease burden. Furthermore, a greater awareness of gender differences in HS may be important for dermatologists in their own clinical practice (i.e., pregnancy and breastfeeding). Consequently, in this loop interaction, comprehensive knowledge of all factors involved is crucial for the management of HS patients. Thus, the objective of this review is to (i) discuss the influence of gender on HS, (ii) summarize the most frequent triggering factors of HS and (iii) analyze the impact of HS on patient habits.

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What's Race Got to Do With It? CRP Levels in Immune Mediated Skin Diseases: Considerations for Hidradenitis Suppurativa

Cited by 2 publications

References 41 publications

Changes of Serum C-Reactive Protein Level in Patients With Depressive Disorders After Treatment With Agomelatine Combined With Aerobic Exercise and Its Significance

Changes of Serum C-Reactive Protein Level in Patients With Depressive Disorders After Treatment With Agomelatine Combined With Aerobic Exercise and Its Significance

Hidradenitis Suppurativa: The Influence of Gender, the Importance of Trigger Factors and the Implications for Patient Habits

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