What should be treatment approach in metaplastic breast cancer? A report of 5 cases

Acar, Turan; Acar, Nihan; Sezgin, Gülten Can; Gokova, Melek Bekler; Kucukzeybek, Betul Bolat; Hacıyanlı, Mehmet

doi:10.14744/nci.2018.09124

Cited by 5 publications

(5 citation statements)

References 17 publications

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“…Therefore, these 77 articles were excluded. Overall, 65 studies [ 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 ...…”

Section: Resultsmentioning

confidence: 99%

“…The hematogenous spreading route is particularly more common in subtypes with predominant sarcomatoid carcinoma in the spectrum [ 9 , 14 , 26 ]. Acar et al reported that the risk of distant metastasis was higher in MpBC patients than in patients with ductal or lobular adenocarcinomas, while the risk of lymph node involvement was lower in MpBC patients [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

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Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

et al. 2023

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Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identified by searching CASES SERIES gov and the MEDLINE bibliographic database for the period of 1 January 2010 to 1 June 2021 with the keywords metaplastic breast cancer, mammary gland cancer, neoplasm, tumor, and metaplastic carcinoma. In this study, we also report 46 cases of MpBC stemming from our hospital. Survival rates, clinical behavior, and pathological characteristics were analyzed. Data from 205 patients were included for analysis. The mean age at diagnosis was 55 (14.7) years. The TNM stage at diagnosis was mostly stage II (58.5%) and most tumors were triple negative. The median overall survival was 66 (12–118) months, and the median disease-free survival was 56.8 (11–102) months. Multivariate Cox regression analysis revealed that surgical treatment was associated with decreased risk of death (hazard ratio 0.11, 95% confidence interval 0.02–0.54, p = 0.01) while advanced TNM stage was associated with increased risk of death (hazard ratio 1.5, 95% confidence interval 1.04–2.28, p = 0.03). Our results revealed that surgical treatment and TNM stage were the only independent risk factors related to patients’ overall survival.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

et al. 2023

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“…Despite the larger tumor size, MBC is less commonly associated with axillary node involvement (6 %–26 % of cases) compared to standard invasive breast cancer [ 9 ]. MBC commonly metastasizes to the lungs and bone tissue via the bloodstream [ 10 ]. A review of 15 clinical cases, retrieved from PubMed, was conducted and the results are presented in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

A giant metaplastic breast carcinoma with osseous differentiation: A rare case report and review of the literature

Do,

Nguyen,

Van Nguyen

et al. 2024

International Journal of Surgery Case Reports

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“…MBC: metaplastic breast carcinoma; NSIBC: nonspecific invasive breast carcinoma; ER: estrogen receptor; PR: progesterone receptor; Her-2: human epidermal growth factor receptor 2. e Breast Journal 3 is poorly differentiated and greatly aggressive [10]. Previous studies showed that MBC mainly metastasized via the lymphatics and blood, and early hematogenous metastasis often involved the lung and the bone, especially in metaplastic carcinoma with mesenchymal differentiation [11]. ere were 11 cases of carcinoma with mesenchymal differentiation, of which 9 cases could obtain follow-up data.…”

Section: Discussionmentioning

confidence: 99%

Differences of Clinicopathological Features between Metaplastic Breast Carcinoma and Nonspecific Invasive Breast Carcinoma and Prognostic Profile of Metaplastic Breast Carcinoma

Qiu

Chen

et al. 2022

The Breast Journal

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Introduction. Metaplastic breast carcinoma is a rare special type of breast cancer, which has distinguished clinical characteristics. We aimed to evaluate the clinicopathological features of metaplastic breast carcinoma compared with nonspecific invasive breast carcinoma and study the prognosis of metaplastic breast carcinoma. Methods. We reviewed metaplastic breast carcinoma cases (n = 37) from January 2000 to December 2021 and nonspecific invasive breast carcinoma cases (n = 433) from January 2019 to December 2020 extracted from our institution retrospectively. The following variables were recorded, including the patients’ general information, complications, T stage, expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2, Ki-67, molecular subtyping, lymph node status, skin or chest wall involvement, vessel carcinoma embolus, therapy modality (surgical treatments, chemotherapy, and radiotherapy), and survival. Results. Patients with metaplastic breast carcinoma had more advanced disease than patients with nonspecific invasive breast carcinoma (T stage: P = 0.0011 ). A greater proportion of metaplastic breast carcinoma presented with triple-negative breast cancer than nonspecific invasive breast carcinoma (79.41% vs. 12.47%, P ≤ 0.001 ). Our study showed that the skin or chest wall invasion was more frequent in metaplastic breast carcinoma patients (11.76% vs. 1.62%, P = 0.005 ). The 5-year survival rate for metaplastic breast carcinoma patients was 57.66% (95% CI: 0.3195∼0.7667). No local recurrence was observed while distant metastasis occurred in 33.33% of patients with metaplastic breast carcinoma. Death due to disease occurred in 24.24% of patients with metaplastic breast carcinoma. Conclusion. The majority of metaplastic breast carcinoma patients had more advanced disease and triple-negative disease than nonspecific invasive breast carcinoma patients. Also, metaplastic breast carcinoma patients had frequent skin or chest wall invasion and a high rate of distant metastasis and mortality.

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What should be treatment approach in metaplastic breast cancer? A report of 5 cases

Cited by 5 publications

References 17 publications

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature

A giant metaplastic breast carcinoma with osseous differentiation: A rare case report and review of the literature

Differences of Clinicopathological Features between Metaplastic Breast Carcinoma and Nonspecific Invasive Breast Carcinoma and Prognostic Profile of Metaplastic Breast Carcinoma

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