What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the <scp>ENIGMA</scp> Bipolar Disorder Working Group

Ching, Christopher R. K.; Hibar, Derrek P.; Gurholt, Tiril P.; Nunes, Abraham; Thomopoulos, Sophia I; Abé, Christoph; Agartz, Ingrid; Brouwer, Rachel M.; Cannon, Dara M.; Zwarte, Sonja M C de; Eyler, Lisa T.; Favre, Pauline; Hájek, Tomáš; Haukvik, Unn K.; Houenou, Josselin; Landén, Mikael; Lett, Tristram A.; McDonald, Colm; Nabulsi, Leila; Patel, Yash; Pauling, Melissa; Paus, Tomáš; Raduà, Joaquim; Soeiro-de-Souza, Márcio G.; Tronchin, Giulia; Haren, Neeltje E.M. van; Vieta, Eduard; Walter, Henrik; Zeng, Ling‐Li; Alda, Martin; Almeida, Jorge; Alnæs, Dag; Alonso‐Lana, Silvia; Altimus, Cara M.; Bauer, Michael; Baune, Bernhard T.; Bearden, Carrie E.; Bellani, Marcella; Benedetti, Francesco; Berk, Michael; Bilderbeck, Amy C.; Blumberg, Hilary P.; Bøen, Erlend; Bollettini, Irene; Bonnín, Caterina del Mar; Brambilla, Paolo; Canales-Rodríguez, Erick Jorge; Caseras, Xavier; Dandash, Orwa; Dannlowski, Udo; Delvecchio, Giuseppe; Díaz-Zuluaga, Ana M.; Dima, Danai; Duchesnay, Édouard; Elvsåshagen, Torbjørn; Fears, Scott C.; Frangou, Sophia; Fullerton, Janice M.; Glahn, David C.; Goikolea, José Manuel; Green, Melissa; Grotegerd, Dominik; Gruber, Oliver; Haarman, Bartholomeus C M; Henry, Chantal; Howells, Fleur M.; Ives‐Deliperi, Victoria; Jansen, Andreas; Kircher, Tilo; Knöchel, Christian; Krämer, Bernd; Lafer, Beny; López‐Jaramillo, Carlos; Machado‐Vieira, Rodrigo; MacIntosh, Bradley J.; Melloni, Elisa; Mitchell, Philip B.; Nenadić, Igor; Nery, Fabiano G.; Nugent, Allison C.; Oertel, Viola; Ophoff, Roel A.; Ota, Miho; Overs, Bronwyn; Pham, Dániel; Phillips, Mary L.; Pineda-Zapata, Julián A; Poletti, Sara; Polosan, Mircea; Pomarol‐Clotet, Edith; Pouchon, Arnaud; Quidé, Yann; Rive, Maria M.; Roberts, Gloria; Ruhé, Henricus G.; Salvador, Raymond; Sarró, Salvador; Satterthwaite, Theodore D.; Schene, Aart H.; Sim, Kang; Soares, Jair C.; Stäblein, Michael; Stein, Dan J.; Tamnes, Christian K.; Thomaidis, Georgios; Upeguí, Cristian Vargas; Veltman, Dick J.; Wessa, Michèle; Westlye, Lars T.; Whalley, Heather C.; Wolf, Daniel H.; Wu, Mon-Ju; Yatham, Lakshmi N.; Zarate, Carlos A.; Thompson, Paul M.; Andreassen, Ole A.

doi:10.1002/hbm.25098

Cited by 94 publications

(81 citation statements)

References 138 publications

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“…The ENIGMA-BD Working Group brings together researchers with brain imaging and clinical data from people with BD [5,23,35,36]. Seventeen site members of this group from 13 countries on 6 continents contributed individual subject structural MRI data, medication information, and BMI values from a total of 1134 individuals with BD and 1601 healthy controls.…”

Section: Participating Sitesmentioning

confidence: 99%

Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

McWhinney¹,

Abé²,

Alda³

et al. 2021

Mol Psychiatry

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Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI (Z = 2.73, p = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.

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Section: Participating Sitesmentioning

confidence: 99%

Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

McWhinney¹,

Abé²,

Alda³

et al. 2021

Mol Psychiatry

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“…Ever since early studies demonstrated an association between ventriculomegaly and schizophrenia, neuroimaging has been seen as a potentially influential tool in diagnostic psychiatry [1]. The fundamental drive behind psychoradiology has been conceptualized as providing an interface between traditional phenomenological constructs and behavior and the underlying biology of psychiatric illnesses [2]. That is, neuroimaging has the potential to assist a clinician in delving closer to the organic source of the psychopathology as opposed to using behavioral factors alone.…”

Section: Introductionmentioning

confidence: 99%

“…Bipolar disorder (BD) is a serious mental disorder characterized by episodic affective instability, with the disease course fluctuating between depression, mania, and hypomania [2]. As shown in Figure 1, patients with BPD and BD can exhibit significant overlap in symptomatology.…”

Section: Introductionmentioning

confidence: 99%

“…As shown in Figure 1, patients with BPD and BD can exhibit significant overlap in symptomatology. Structural and functional neuroimaging have been used to investigate BD for several decades to assist an earlier diagnosis of BD and/or reveal tangible changes that may correlate with its behavioral symptoms [2]. A clinical diagnosis of BD is frequently delayed, with some studies reporting the time between patient presentation and formal diagnosis being over 10 years [5,6].…”

Section: Introductionmentioning

confidence: 99%

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Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder

Ding¹,

Hu²

2021

Cureus

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Bipolar disorder (BD) and borderline personality disorder (BPD) share many behavioral features, such as periods of marked affective lability and instability. Although there is a symptomatic overlap, the two disorders may be differentiated based on longitudinal course, phenomenology, and treatment responsiveness. In addition, the emotional changes in BPD are generally influenced by interpersonal factors, whereas BD episodes tend to be more sustained. We performed a literature review on the structural MRI features of both disorders and compared the findings. There are differences in areas of white and gray matter volumes and thickness in BP and BPD. BPD primarily affects the fronto-limbic network, in particular, the amygdala, hippocampus, and orbitofrontal cortex, whereas BP affects both cortical and subcortical areas. There are a limited number of large studies, and many studies examined in this review did not adjust for confounding factors or motion artifacts, which limit the utility of current data.

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“… 44 Most studies have investigated these modalities separately, but the emergence of big datasets and new methodological advances allow multimodal investigation of finer phenotypic features with better power to detect smaller effects and capture complex interactions. To ease the economic and time burden associated with the recruitment and management of new studies, large-scale consortia have emerged and provide disorder-specific frameworks, such as the BD working group of the Enhanced NeuroImaging Genetics through Meta-analysis (ENIGMA) consortium 45 and the Psychiatric Genomics Consortium (PGC). 46 These consortia are still in their early stages, but represent promising avenues to increase our understanding of the development of severe psychiatric disorders, such as BD.…”

Section: Introductionmentioning

confidence: 99%

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

Quidé¹,

Tozzi²,

Corcoran³

et al. 2020

NDT

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Childhood trauma (CT) has been repeatedly linked to earlier onset and greater severity of bipolar disorder (BD) in adulthood. However, such knowledge is mostly based on retrospective and cross-sectional studies in adults with BD. The first objective of this selective review is to characterize the short-term effects of CT in the development of BD by focusing on studies in young people. The second objective is to describe the longer-term consequences of CT by considering studies with adult participants. This review first outlines the most prominent hypotheses linking CT exposure and the onset of BD. Then, it summarizes the psychological and biological risk factors implicated in the development of BD, followed by a discussion of original studies that investigated the role of CT in young people with early-onset BD, youths at increased risk of developing BD, or young people with BD with a focus on subclinical and clinical outcome measures. The review considers additional biological and psychological factors associated with a negative impact of CT on the long-term course of BD in later adulthood. Finally, we discuss how the integration of information of CT can improve ongoing early identification of BD and mitigate severe clinical expression in later adulthood.

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What we learn about bipolar disorder from large‐scale neuroimaging: Findings and future directions from the ENIGMA Bipolar Disorder Working Group

Abstract: The members of the collaboration are provided in Appendix A.

Cited by 94 publications

References 138 publications

Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

Structural MRI Brain Alterations in Borderline Personality Disorder and Bipolar Disorder

<p>The Impact of Childhood Trauma on Developing Bipolar Disorder: Current Understanding and Ensuring Continued Progress</p>

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