Wheezing and itching

Abstract

The development of allergic inflammation requires the orchestration of gene expression from the inflamed tissue and from the infiltrating immune cells. Since many of the cytokines that promote allergic inflammation signal through hematopoietin family receptors, the Signal Transducer and Activator of Transcription (STAT) family have obligate roles in pro-allergic cytokine-induced gene regulation in multiple cell types. In this review, we summarize work defining the contribution of each of the STAT family members to the development of allergic inflammation, using data from mouse models of allergic inflammation, studies on patient samples and correlations with single nucleotide polymorphisms in STAT genes.

Signal Transducer and Activator of Transcription (STATs) Proteins in Cancer and Inflammation: Functions and Therapeutic Implication

“…STAT2, STAT4, and STAT6 are stimulated by certain cytokines, such as IL-12, IL-4/IL-13, and IFN-α (19). Development of T helper cells by STAT6 contributes in a positive way in modulating inflammation during allergy while in negative way in autoimmunity (20). Consequently, differentiation of type 1 T helper cells by STAT4 was essential for autoimmune and inflammatory disorders.…”

STAT signaling in inflammation

“…STAT6 was the first STAT shown to be required for differentiation of a T helper subset. STAT6-dependent Th2 development contributes to a variety of inflammatory diseases, positively impacting allergic inflammation and negatively affecting autoimmunity 5 , 6 . Subsequently, STAT4-dependent Th1 differentiation was shown to be required for autoimmunity and inflammatory disease 7 .…”

Anti-STAT6 CTL activity inStat6−/−mice

“…In some situations the responses described here may not obviously affect experimental results. For example, in evaluations of immune responses within Stat6 −/− mice against exogenous antigens or allergens, or in studies of inflammation or hypersensitivity, the results may show no effects easily attributable to altered peptide presentation by MHC class I molecules on Stat6 −/− cells 2 , 8 . However, it is possible that results could be influenced by subtle changes in reactivity of cells maturing in the Stat6 −/− environment and/or by the unusual peptide repertoire transferred on H2 d molecules with Stat6 −/− cells.…”