When antimicrobial stewardship programmes reach the home

Cortés, Luis Eduardo López; Navarro, María Victoria Gil; Márquez, Rafael Luque

doi:10.1016/j.eimc.2021.03.002

Cited by 3 publications

(5 citation statements)

References 11 publications

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“…Nevertheless, it is important to highlight that the use of this OPAT option must be implemented prudently and rationally, according the practice antimicrobial stewardship principles. [25][26][27] Misuse should be averted, in order to avoid potential toxicities, development of resistances, and higher costs.…”

Section: Discussionmentioning

confidence: 99%

Outpatient parenteral antimicrobial therapy with continuous infusion of meropenem: A retrospective analysis of three years of clinical experience

Dubois-Silva

Otero-Plaza

Dopico-Santamariña

et al. 2023

Enfermedades Infecciosas y Microbiología Clínica

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Section: Discussionmentioning

confidence: 99%

Outpatient parenteral antimicrobial therapy with continuous infusion of meropenem: A retrospective analysis of three years of clinical experience

Dubois-Silva

Otero-Plaza

Dopico-Santamariña

et al. 2023

Enfermedades Infecciosas y Microbiología Clínica

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Section: Discussionmentioning

confidence: 99%

Outpatient parenteral antimicrobial therapy with continuous infusion of meropenem: A retrospective analysis of three years of clinical experience

Dubois-Silva

Otero-Plaza

Dopico-Santamariña

et al. 2023

Enfermedades infecciosas y microbiologia clinica (English ed.)

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“…These observational studies, compared to the efficacy and safety of standard care treatment (cefazolin or anti-staphylococcal penicillins), with ceftriaxone treatment for MSSA infections and reporting heterogeneous results, must be considered with caution. Furthermore, regarding antimicrobial stewardship, OPAT programs are a powerful tool to promote the appropriate use of antimicrobials [ 32 ]. Ceftriaxone spectrum is broader than the standard care treatment for MSSA infections and its use should be avoided whenever possible due to their ability to select extended-spectrum beta-lactamase-producing Enterobacterales and the high risk of Clostridioides difficile infection [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, regarding antimicrobial stewardship, OPAT programs are a powerful tool to promote the appropriate use of antimicrobials [ 32 ]. Ceftriaxone spectrum is broader than the standard care treatment for MSSA infections and its use should be avoided whenever possible due to their ability to select extended-spectrum beta-lactamase-producing Enterobacterales and the high risk of Clostridioides difficile infection [ 32 , 33 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Clinical Outcomes of an Innovative Cefazolin Delivery Program for MSSA Infections in OPAT

Herrera‐Hidalgo

Luque‐Márquez

Alarcón

et al. 2022

JCM

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Cefazolin is a recommended treatment for methicillin-susceptible Staphylococcus aureus (MSSA) infections that has been successfully used in outpatient parenteral antibiotic therapy (OPAT) programs. The aim of this study was to assess the clinical outcomes of cefazolin delivered each day (Group 24) vs. every two days (Group 48) for MSSA infections in OPAT programs. It was a prospective observational study with retrospective analysis of a cohort of MSSA infections attended in OPAT. The primary outcome was treatment success, defined as completing the antimicrobial regimen without death, treatment discontinuation, or readmission during treatment and follow-up. A univariate and multivariate logistic regression model was built. A two-sided p < 0.05 was considered statistically significant. Of the 149 MSSA infections treated with cefazolin 2 g/8 h in OPATs, 94 and 55 patients were included in the delivery Group 24 and Group 48, respectively. Treatment failure and unplanned readmission rates were similar in both groups (11.7% vs. 7.3% p = 0.752 and 8.5% vs. 5.5% p = 0.491). There was a significant increase in vascular access complications in Group 24 (33.0%) with respect to Group 48 (7.3%) (p < 0.001). Treating uncomplicated MSSA infection with cefazolin home-delivered every two days through an OPAT program is not associated with an increased risk of treatment failure and entails a significant reduction in resource consumption compared to daily delivery.

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When antimicrobial stewardship programmes reach the home

Cited by 3 publications

References 11 publications

Outpatient parenteral antimicrobial therapy with continuous infusion of meropenem: A retrospective analysis of three years of clinical experience

Outpatient parenteral antimicrobial therapy with continuous infusion of meropenem: A retrospective analysis of three years of clinical experience

Outpatient parenteral antimicrobial therapy with continuous infusion of meropenem: A retrospective analysis of three years of clinical experience

Clinical Outcomes of an Innovative Cefazolin Delivery Program for MSSA Infections in OPAT

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