When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection

Pacis, Alain; Nédélec, Yohann; Barreiro, Luis B.

doi:10.1016/j.coi.2014.06.002

Cited by 16 publications

(13 citation statements)

References 65 publications

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“…Significant individual differences in USVs have been observed in mice and rats, as well as in the individual variation in immune responses . Particularly interesting in the context of this article is the work of Bronson and colleagues, who using a poly I:C MIA model in rats reported that individual differences in the maternal response to immune challenge influence the behavioral response in the offspring …”

Section: Common Traits Between Immunity and Vocalizationmentioning

confidence: 91%

Immunity and ultrasonic vocalization in rodents

Jouda

Wöhr

Rey

2018

Annals of the New York Academy of Sciences

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Ultrasonic vocalizations (USVs) serve important communicative functions in rodents. Different types of USVs can be triggered in the sender, for example, by maternal separation, social interactions, or exposure to predators, and they evoke affiliative or alarming behaviors in recipients. This review focusses on studies evaluating possible links between immunity and USVs. Most studies have been performed in a murine model of maternal immune activation and subsequent evaluation of effects in the offspring. This model has received large attention in recent years because it mimics behavioral abnormalities observed in certain human neuropsychiatric disorders, including autism spectrum disorder. Although there is still some controversy, the results indicate that stimulation of the immune system of mice and rats during pregnancy affects ultrasonic calling in pups. Few studies are available on immunization during adulthood and USVs. In most cases, immune stimulation led to disease, complicating conclusions about a possible direct link between vocalization and immunity. Although much work is still needed, this is certainly a rather new and promising aspect of interactions between the immune system and behavior.

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Section: Common Traits Between Immunity and Vocalizationmentioning

confidence: 91%

Immunity and ultrasonic vocalization in rodents

Jouda

Wöhr

Rey

2018

Annals of the New York Academy of Sciences

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“…The nucleotide excision repair (NER) mechanism is responsible for the surveillance and removal of UV-induced DNA damage and other lesions that may induce distortion of the DNA helix in various cells, most particularly in keratinocytes which are constantly exposed to UV radiation (Du et al, 2015;Feng et al, 2014;Kratochwil and Meyer, 2015;Pacis et al, 2014).…”

Section: Dna Damage Repairmentioning

confidence: 99%

Heat stress: A risk factor for skin carcinogenesis

2013

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“…Another approach to functional validation are eQTL studies, where the association between genetic variants and RNA expression levels are demonstrated. This has proven quite insightful into TB biology [69, 70]. …”

Section: Necessary Future Directionsmentioning

confidence: 99%

Genomics of Human Pulmonary Tuberculosis: from Genes to Pathways

et al. 2017

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Purpose of review Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major public health threat globally. Several lines of evidence support a role for host genetic factors in resistance/susceptibility to TB disease and MTB infection. However, results across candidate gene and genome-wide association studies (GWAS) are largely inconsistent, so a cohesive genetic model underlying TB risk has not emerged. Recent Findings Despite the difficulties in identifying consistent genetic associations, genetic studies of TB and MTB infection have revealed a few well-documented loci. These well validated genes are presented in this review, but there remains a large gap in how these genes translate into better understanding of TB. To address this, we present a pathway based extension of standard association analyses, seeding the results with the best validated genes from candidate gene and GWAS studies. Summary Several pathways were significantly enriched using pathway analyses that may help to explain population patterns of TB risk. In conclusion, we advocate for novel approaches to the study of host genetic analysis of TB that extend traditional association approaches.

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When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection

Cited by 16 publications

References 65 publications

Immunity and ultrasonic vocalization in rodents

Immunity and ultrasonic vocalization in rodents

Heat stress: A risk factor for skin carcinogenesis

Genomics of Human Pulmonary Tuberculosis: from Genes to Pathways

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