When is Lugol still necessary in 2020?

Ven, Steffi Elisabeth Maria van de; Koch, Arjun D.

doi:10.1055/a-1216-1864

Cited by 3 publications

(5 citation statements)

References 13 publications

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“…In case a synchronous oesophageal SPT is detected, one could argue that these patients probably had mucosal dysplasia or neoplasia at the time of the primary ESCC diagnosis. Careful inspection of the oesophagus with Lugol chromoendoscopy is therefore very important in cases of curative primary ESCC diagnosis, because early oesophageal SPT might be easily overlooked during routine white light endoscopy 33 …”

Section: Discussionmentioning

confidence: 99%

“…Careful inspection of the oesophagus with Lugol chromoendoscopy is therefore very important in cases of curative primary ESCC diagnosis, because early oesophageal SPT might be easily overlooked during routine white light endoscopy. 33 Patients who develop metachronous SPT may potentially benefit from screening programmes. The median time between ESCC diagnosis and metachronous SPT detection was 3 years (IQR 1.…”

Section: Predictive Factors For Mptsmentioning

confidence: 99%

“…(Table3). Sub-analyses showed that patients with ESCC had the highest risk of developing synchronous (SIR 36 33,. 99% CI 29.44-44.30) and metachronous (SIR 14.17, 99% CI 10.41-17.52) MPTs in the head and neck region.…”

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confidence: 99%

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Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

et al. 2021

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Background Patients with primary oesophageal squamous cell carcinoma are at risk of developing multiple primary tumours in the upper aero digestive tract. To date, most studies are performed in the Asian population. We aimed to evaluate the risk of multiple primary tumours in the upper aero digestive tract and stomach in patients with oesophageal squamous cell carcinoma in a Western population. Methods We performed a nationwide, retrospective cohort study in collaboration with the Netherlands Cancer Registry. Patients with primary oesophageal squamous cell carcinoma, diagnosed between 2000–2016, were included. Primary endpoints were synchronous and metachronous multiple primary tumour risk. Results The cohort consisted of 9058 patients, diagnosed with oesophageal squamous cell carcinoma (male: 57.3%, median age 67 years). In 476 patients (5.3%), 545 multiple primary tumours have been diagnosed. Most of them were located in the head and neck region (49.5%). Among all multiple primary tumours, 329 (60.4%) were diagnosed synchronously (<6 months after oesophageal squamous cell carcinoma diagnosis) and 216 (39.6%) metachronously (≥6 months). Patients with oesophageal squamous cell carcinoma had a significantly increased risk of both synchronous (standardised incidence ratio 10.95, 99% confidence interval 9.40–12.53) and metachronous multiple primary tumours (standardised incidence ratio 4.36, 99% confidence interval 3.56–5.10), compared to the general population. The median interval to metachronous second primary tumour diagnosis was 3.0 years (interquartile range 1.8–5.9). Conclusion Approximately one in 20 patients with primary oesophageal squamous cell carcinoma have a second primary tumour in the upper aero digestive tract or stomach, either at the time of oesophageal squamous cell carcinoma diagnosis or at a later stage. As second primary tumours occur at an increased risk compared to the general population, prospective studies are necessary to investigate the yield and survival benefit of screening for second primary tumours in patients with oesophageal squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 99%

Section: Predictive Factors For Mptsmentioning

confidence: 99%

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Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

et al. 2021

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“… 30 LCE is helpful to highlight suspected lesions but endoscopist’ experience is still key in the characterization and detection of suspected ESPT. 31 …”

Section: Discussionmentioning

confidence: 99%

Screening for synchronous esophageal second primary tumors in patients with head and neck cancer

Ven

Graaf

Bugter

et al. 2021

Diseases of the Esophagus

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Summary Patients with head and neck squamous cell carcinoma (HNSCC) have an increased risk of developing esophageal second primary tumors (ESPTs). We aimed to determine the incidence, stage, and outcome of synchronous ESPTs in patients with HNSCC in a Western population. We performed a prospective, observational, and cohort study. Patients diagnosed with HNSCC in the oropharynx, hypopharynx, any other sub-location in combination with alcohol abuse, or patients with two synchronous HNSCCs, between February 2019 and February 2020 underwent screening esophagogastroduodenoscopy (EGD). ESPT was defined as presence of esophageal squamous cell carcinoma (ESCC) or high grade dysplasia (HGD). Eighty-five patients were included. A lesion suspected for ESPT was detected in 14 of 85 patients, which was pathologically confirmed in five patients (1 ESCC and 4 HGD). The radiotherapy field was extended to the esophagus in two of five patients, HGD was treated with endoscopic resection in three of five patients. None of the ESPTs were detected on MRI and/or CT-scan prior to EGD. Of the remaining nine patients, three had low grade dysplasia on histology whereas the other six patients had benign lesions. Incidence of synchronous ESPT was 5.9% in our cohort of HNSCC patients. All ESPTs were diagnosed at an early stage and treated with curative intent. We recommend that screening for synchronous ESPTs should be considered in a selected group of patients with HNSCC.

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“…30 LCE is helpful to highlight suspected lesions but endoscopist' experience is still key in the characterization and detection of suspected ESPT. 31 Our study is subject to certain limitations. First, we included relatively few patients.…”

Section: Discussionmentioning

confidence: 91%

Screening for Synchronous Esophageal Second Primary Tumors in Patients With Head and Neck Cancer

et al. 2021

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Patients with head and neck squamous cell carcinoma (HNSCC) have an increased risk of developing esophageal second primary tumors (ESPTs). We aimed to determine the incidence, stage, and outcome of synchronous ESPTs in patients with HNSCC in a Western population. We performed a prospective, observational, and cohort study. Patients diagnosed with HNSCC in the oropharynx, hypopharynx, any other sub-location in combination with alcohol abuse, or patients with two synchronous HNSCCs, between February 2019 and February 2020 underwent screening esophagogastroduodenoscopy (EGD). ESPT was defined as presence of esophageal squamous cell carcinoma (ESCC) or high grade dysplasia (HGD). Eighty-five patients were included. A lesion suspected for ESPT was detected in 14 of 85 patients, which was pathologically confirmed in five patients (1 ESCC and 4 HGD). The radiotherapy field was extended to the esophagus in two of five patients, HGD was treated with endoscopic resection in three of five patients. None of the ESPTs were detected on MRI and/or CT-scan prior to EGD. Of the remaining nine patients, three had low grade dysplasia on histology whereas the other six patients had benign lesions. Incidence of synchronous ESPT was 5.9% in our cohort of HNSCC patients. All ESPTs were diagnosed at an early stage and treated with curative intent. We recommend that screening for synchronous ESPTs should be considered in a selected group of patients with HNSCC.

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When is Lugol still necessary in 2020?

Cited by 3 publications

References 13 publications

Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

Increased risk of second primary tumours in patients with oesophageal squamous cell carcinoma: a nationwide study in a Western population

Screening for synchronous esophageal second primary tumors in patients with head and neck cancer

Screening for Synchronous Esophageal Second Primary Tumors in Patients With Head and Neck Cancer

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