When Land Is Under Pressure Health Is Under Stress

Sena, Aderita; Ebi, Kristie L.

doi:10.3390/ijerph18010136

Cited by 14 publications

(13 citation statements)

References 88 publications

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“…Additionally, as a major source of protein for human beings, Cd in ducks can enter the body through the food chain and accumulate, causing harm. Previous studies proved that Cd could lead to chronic kidney disease and bone injury [ 5 ]. After ingestion of contaminated water and food by a human or animal, Cd primarily aggregates in the form of Cd-metallothionein complex in the liver and kidneys, and its turnover rate is excessively slow, which can disrupt the stability of essential metals such as zinc (Zn) and cuprum (Cu), reduce the capacity of cells to purge reactive oxygen species (ROS), cause oxidative stress and inflammation, and ultimately undermine organ function [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Selenium Antagonizes Cadmium-Induced Inflammation and Oxidative Stress via Suppressing the Interplay between NLRP3 Inflammasome and HMGB1/NF-κB Pathway in Duck Hepatocytes

Cao

Yang

Lin

et al. 2022

IJMS

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Cadmium (Cd) is a toxic heavy metal that can accumulate in the liver of animals, damaging liver function. Inflammation and oxidative stress are considered primary causes of Cd-induced liver damage. Selenium (Se) is an antioxidant and can resist the detrimental impacts of Cd on the liver. To elucidate the antagonism of Se on Cd against hepatocyte injury and its mechanism, duck embryo hepatocytes were treated with Cd (4 μM) and/or Se (0.4 μM) for 24 h. Then, the hepatocyte viability, oxidative stress and inflammatory status were assessed. The findings manifested that the accumulation of reactive oxygen species (ROS) and the levels of pro-inflammatory factors were elevated in the Cd group. Simultaneously, immunofluorescence staining revealed that the interaction between NOD-like receptor pyran domain containing 3 (NLRP3) and apoptosis-associated speck-like protein (ASC) was enhanced, the movement of high-mobility group box 1 (HMGB1) from nucleus to cytoplasm was increased and the inflammatory response was further amplified. Nevertheless, the addition of Se relieved the above-mentioned effects, thereby alleviating cellular oxidative stress and inflammation. Collectively, the results suggested that Se could mitigate Cd-stimulated oxidative stress and inflammation in hepatocytes, which might be correlated with the NLRP3 inflammasome and HMGB1/nuclear factor-κB (NF-κB) signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Selenium Antagonizes Cadmium-Induced Inflammation and Oxidative Stress via Suppressing the Interplay between NLRP3 Inflammasome and HMGB1/NF-κB Pathway in Duck Hepatocytes

Cao

Yang

Lin

et al. 2022

IJMS

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“…Their accelerating trends are predicted under certain scenarios of greenhouse gas emissions [2,10,16,27,33,38,40]. Historically, extreme weather and climate events are generally rare across the globe, with a time interval between events that allow human and natural systems to recover from the impacts experienced [30,37,39].…”

Section: Introductionmentioning

confidence: 99%

“…Significant and increasing direct and indirect impacts of extreme temperature events on human health -excessive morbidity and mortality [2,8,, negative effects on mental health [8,53,124,[129][130][131][132][133][134][135][136], human and community well-being [1,8,30,76,86,120,126,129,130], and health care systems [57,125,137] -are becoming an increasingly urgent global problem. Much is known about health consequences of heat and cold waves [1,[42][43][44][46][47][48][49]51,55,56,62,[69][70][71][72][73][74]79,81,83,86,[93][94]...…”

Section: Introductionmentioning

confidence: 99%

Health Risks to the Russian Population from Temperature Extremes at the Beginning of the XXI Century

Grigorieva

Revich

2021

Atmosphere

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Climate change and climate-sensitive disasters caused by climatic hazards have a significant and increasing direct and indirect impact on human health. Due to its vast area, complex geographical environment and various climatic conditions, Russia is one of the countries that suffers significantly from frequent climate hazards. This paper provides information about temperature extremities in Russia in the beginning of the 21st century, and their impact on human health. A literature search was conducted using the electronic databases Web of Science, Science Direct, Scopus, and e-Library, focusing on peer-reviewed journal articles published in English and in Russian from 2000 to 2021. The results are summarized in 16 studies, which are divided into location-based groups, including Moscow, Saint Petersburg and other large cities located in various climatic zones: in the Arctic, in Siberia and in the southern regions, in ultra-continental and monsoon climate. Heat waves in cities with a temperate continental climate lead to a significant increase in all-cause mortality than cold waves, compared with cities in other climatic zones. At the same time, in northern cities, in contrast to the southern regions and central Siberia, the influence of cold waves is more pronounced on mortality than heat waves. To adequately protect the population from the effects of temperature waves and to carry out preventive measures, it is necessary to know specific threshold values of air temperature in each city.

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“…Istanbuly et al [ 33 ] addressed the relationship between socioeconomic variables and soil erosion in Polish catchments, while Cao et al [ 34 ] evaluated the interaction between poverty reduction and ecosystem services in poverty counties, something essential to promote rural revitalisation strategy and the construction of an ecological civilisation. Finally, Sena and Ebi [ 35 ] highlighted the pressures and impacts of desertification, land degradation and drought on human health.…”

Section: Introductionmentioning

confidence: 99%

Restoring Coal Mining-Affected Areas: The Missing Ecosystem Services

Krzemień

Fernández

et al. 2022

IJERPH

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Multi-criteria decision analysis and cost-benefit analysis, either individually or in combination, have been used as the preferred tools to develop ecosystem services valuation, presenting significant discrepancies and variations between the calculated values. To counteract this problem, a new framework was developed based on a hierarchical weighting of the non-provisioning ecosystem services, using biodiversity as the reference ecosystem service since it is the easiest to apprehend. Their monetisation was made using the average price of EU carbon dioxide emission allowances during 2019 and 2020, obtaining reasonable and comparable results in line with what was expected for the study region. However, the revised EU Emissions Trading System Directive, which will apply from 2021–2030, generated a price escalation of carbon allowances, making it necessary to adjust or rethink the proposed framework. To achieve this goal, the paper proposes the introduction of new vectors or “missing ecosystem services” to counterbalance efforts to eliminate carbon dioxide emissions without necessarily removing humans from the equation: welfare and human health. As the linkages regarding ecosystem health, ecological restoration and human health are not well known, only welfare was incorporated into the framework. The results were highly satisfactory, in line with what was expected for the study region and the ones obtained before the price escalation of carbon allowances that started in 2021.

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When Land Is Under Pressure Health Is Under Stress

Cited by 14 publications

References 88 publications

Selenium Antagonizes Cadmium-Induced Inflammation and Oxidative Stress via Suppressing the Interplay between NLRP3 Inflammasome and HMGB1/NF-κB Pathway in Duck Hepatocytes

Selenium Antagonizes Cadmium-Induced Inflammation and Oxidative Stress via Suppressing the Interplay between NLRP3 Inflammasome and HMGB1/NF-κB Pathway in Duck Hepatocytes

Health Risks to the Russian Population from Temperature Extremes at the Beginning of the XXI Century

Restoring Coal Mining-Affected Areas: The Missing Ecosystem Services

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