When Nerve Growth Factor Met Behavior

Santucci, Daniela; Racca, Arianna; Alleva, Enrico

doi:10.1007/978-3-030-74046-7_13

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…The articles published in this issue are part of a scientific contribution presented and discussed at the Second International NGF scientific meeting dedicated to Rita Levi-Montalcini, held in Bologna on June [13][14]2019, and organized by Laura Calzà, Luigi Aloe, and Luciana Giardino. A major aim of this international NGF meeting was to bring attendees up to date on the past, recent, and ongoing studies in the field of the Italian Nobel Laureate in Physiology or Medicine who discovered the first neurotrophic factor, providing neurologists with a powerful tool for investigating the growth, differentiation, and plasticity of nerve cells, as well as paving the way for the identification of other specific growth factors for other cell types.…”

Section: Recent Advances In Ngf and Related Moleculesmentioning

confidence: 99%

Recent Advances in NGF and Related Molecules

2021

Advances in Experimental Medicine and Biology

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This book subseries publishes reviews and original articles covering all aspects of cellular and systems neuroscience, particularly neural circuits. It is also open to contributions on neurological disorders and their molecular and biochemical basis. A subseries of the highly successful Advances in Experimental Medicine and Biology, it provides a publication vehicle for articles focusing on the latest research, developments and methods, as well as opinions and principles. Contributors are experienced neuroscientists and researchers with extensive knowledge of the embryology, histology, anatomy, physiology and pharmacology of central and peripheral neurons. It endeavors to highlight the importance of the correct choice of animal models and the implementation of the 3Rs principles to translate molecular and cellular findings of basic research into clinical applications. This series is a valuable source of state-of-art knowledge and inspiration for future research ideas for a wide range of researchers and animal care professionals working in the field of neuroscience.

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Section: Recent Advances In Ngf and Related Moleculesmentioning

confidence: 99%

Recent Advances in NGF and Related Molecules

2021

Advances in Experimental Medicine and Biology

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“…The finding that such substances exist was made by Levi-Montalcini and Burger in 1951 and from their part of work on the organic properties of nerve-development factors both in vivo and in vitro [16], has been expressed, much in them by Levi-Montalcini and her coworkers for a survey see [17]. The fundamental wellspring of NGF is the sub-maxillary organs of male mice and certain snake venoms [17,18]. NGF is distinguished to be communicated in smooth muscle cells, glandular cells like salivary organs, provocative cells, epithelial cells and fibroblast cells, pee, serum and salivation, and placenta and sex organs.…”

Section: Introductionmentioning

confidence: 99%

“…The nervedevelopment factor is a gathering of proteins that particularly energize the arrangement of nerve strands from the explants of thoughtful ganglia and embryonic dorsal root in vitro [15]. The finding that such substances exist was made by Levi-Montalcini and Burger in 1951 and from their part of work on the organic properties of nerve-development factors both in vivo and in vitro [16], has been expressed, much in them by Levi-Montalcini and her coworkers for a survey see [17]. The fundamental wellspring of NGF is the sub-maxillary organs of male mice and certain snake venoms [17,18].…”

Section: Introductionmentioning

confidence: 99%

Venom Derived Nerve Growth Factors and Their Potential Therapeutic Applications

Ullah¹

2022

AJBSR

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Venom is a natural source of therapeutically active compounds, exhibiting pharmacological action. Nerve growth factors represent a group of proteins responsible for the upkeep and separation of thoughtful and tangible neurons of the fringe sensory system of vertebrates. Many arthropods have been the moderate source of nerve growth factors with contradictory outcomes. Many studies report many diverse nerve growth factors, which are therapeutically and biologically active but differ widely in their isoelectric properties, immunological cross-reactivity with antibodies to mouse b-NGF, endogenous levels of ester peptidase activity as well as molecular weight.

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Effect of Glyprolines on the Level of Nerve Growth Factor Under Conditions of "Social" Stress

Yasenyavskay

Tsibizova

Андреева

et al. 2021

Journal of Volgograd State Medical University

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Today a study aimed at the role of various neurotrophic factors in the implementation of a stress response and their influence on the functioning of the central and peripheral nervous system is of particular interest. Nerve growth factor (NGF) which belongs to a special group of polypeptide regulators has the most expressed neurospecificity. It has been established that this factor has a neuroprotective effect which is realized due to its ability to induce the induction of antiapoptotic proteins and inhibition of proapoptotic ones, thereby affecting the survival rate, as well as the differentiation of individual populations of peripheral neurons. Currently neuropeptide drugs with a wide spectrum of biological activity are considered as the leading stress protectors. Glyproline neuropeptides with proven versatile pharmacological activity, namely neuroprotective, anti-inflammatory, regenerative, immunotropic, etc., attract particular attention. Objective: to study the effect of glyprolines on the level of nerve growth (NGF) in the blood serum of white rats under conditions of "social" stress. Materials and methods. The study was carried out on 90 white non-linear male rats for 6 months. The experimental model of "social" stress was formed as a result of sensory contact for 20 days, followed by the formation of aggressive and submissive types of behavior. Glyproline compounds Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), Pro-Gly-Pro and Pro-Gly-Pro-Leu were injected intraperitoneally at a dose of 100 μg/kg/day from the 1st day of stress exposure by the course 20 days. The level of NGF in the blood serum of white rats was assessed by the enzyme-linked immunosorbent assay using an ELISA Kit for NGF (USA). Results. Exposure to "social stress" led to a decrease in the level of nerve growth factor which probably has a cause-and-effect relationship with a decrease in neurogenetic processes. The observed restoration of the NGF level under the influence of glyprolines Thr-Lys-Pro-Arg-Pro-Gly-Pro (Selank), Pro-Gly-Pro and Pro-Gly-Pro-Leu indicates their stress and neuroprotective activity.

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When Nerve Growth Factor Met Behavior

Cited by 5 publications

References 26 publications

Recent Advances in NGF and Related Molecules

Recent Advances in NGF and Related Molecules

Venom Derived Nerve Growth Factors and Their Potential Therapeutic Applications

Effect of Glyprolines on the Level of Nerve Growth Factor Under Conditions of "Social" Stress

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