When occam's razor can fail– active mycobacteria infection and lung cancer: A case of neuroendocrine lung cancer diagnosed in the setting of refractory mycobacterium avium‐intracellulare

Garg, Navneet; Punch, Chandra; Stein, Michael T.; Schofield, Christina

doi:10.1002/ccr3.1813

Cited by 4 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These cells can inhibit the functions of CD4þ cells and B cells as well as production of antibody. 22,23 FEV1, FEV1%pred, and FEV1%FVC in patients with COPD and pulmonary infection were much lower than in patients with COPD without infection. Similarly, these parameters were lower in patients with COPD compared with healthy individuals.…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

Clinical significance of changes in serum inflammatory factors in patients with chronic obstructive pulmonary disease and pulmonary infection

2021

View full text Add to dashboard Cite

Background Chronic obstructive pulmonary disease (COPD) is often accompanied by pulmonary infection, inflammatory responses, decreased immunity, and decreased lung function. The relationships among the pulmonary inflammation index (PII), lung function, and immunity in COPD patients with pulmonary infection remain unclear. Methods This retrospective observational study enrolled 234 participants (patients with COPD and pulmonary infection, patients with COPD without pulmonary infection, and healthy individuals) from January 2017 to December 2019. Results Levels of interleukin (IL)-6 were lower and levels of IL-8 were higher in patients with COPD and pulmonary infection. Levels of white blood cells (WBCs), C-reactive protein (CRP), IL-6, IL-8, tumor necrosis factor (TNF)-α and CD8+ cells were higher, while levels of CD3+ and CD4+ cells, the CD4+/CD8+ ratio, forced expiratory volume in 1 s (FEV1), FEV1 % predicted (FEV1%pred), and FEV1/forced vital capacity (FVC) (FEV1%FVC) were lower in patients with COPD and pulmonary infection. Levels of WBCs, CRP, IL-6, IL-8, and TNF-α were negatively associated with FEV1, FEV1%pred and FEV1%FVC. Conclusions Patients with COPD and pulmonary infection have high PIIs, decreased immunity, and poor lung function. PII is closely related to lung function and may represent a useful biomarker for the assessment of patients with COPD and pulmonary infection.

show abstract

Section: Discussionmentioning

confidence: 80%

“…These cells can inhibit the functions of CD4+ cells and B cells as well as production of antibody. 22 , 23 …”

Section: Discussionmentioning

confidence: 99%

Clinical significance of changes in serum inflammatory factors in patients with chronic obstructive pulmonary disease and pulmonary infection

2021

View full text Add to dashboard Cite

show abstract

“…In 7 of our 8 patients, such findings were observed in the same lobe as NTM nodule existed and in middle/lingular lobes. In fact, there have been a few case reports of lung cancer coexisting with lung NTM [9][10][11][12][13]. Taking these condition into consideration, at present, both information on lung field in the same or other lobes than lung NTM nodules exist must be comprehensively evaluated.…”

Section: Discussionmentioning

confidence: 99%

“…Although not common, in some patients lung NTM manifests as a solitary nodule, mass, or mass-like consolidation mimicking malignancy [5][6][7][8][9][10][11][12][13]. These lung NTM nodules might be accompanied by these commonly observed parenchymal findings.…”

Section: Introductionmentioning

confidence: 99%

“…These lung NTM nodules might be accompanied by these commonly observed parenchymal findings. In order to complicate this aspect, patients with coexisting lung NTM and lung cancer have also been reported [9][10][11][12][13]. It might be particularly difficult to distinguish NTM nodule from lung cancer in patients with NTM nodule without these lung parenchymal findings.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Imaging characteristics of nontuberculous mycobacterial pulmonary nodules

Nishino

Iguchi

Ishibashi

et al. 2021

Romanian Journal of Internal Medicine

View full text Add to dashboard Cite

Introduction: Nontuberculous mycobacteriosis (NTM) of the lungs can develop nodules. In order to clarify some of the characteristics of lung NTM nodules, we examined volume doubling time (VDT) and maximum standardized uptake value (SUVmax) in positron emission tomography (PET) of pathologically diagnosed NTM nodules. Methods: From November 2012 to August 2018, clinical and radiological information were retrospectively investigated in 8 patients who were surgically resected and diagnosed as NTM. These eight patients were followed up until November 2020 and were confirmed to have no appearance of lung cancer or reappearance of lung NTM nodules. The VDT was calculated using the Schwartz formula. Results: The median maximum diameter of the nodule at the time of the first CT scan was 16.0 (range: 9.9-20.0) mm. The median maximum diameter of the nodule on CT performed before the surgical biopsy was 18.8 (range: 10.4-32.8) mm. The median doubling time calculated from these results was 203 (range: 20-568) days. Caseous granulomas and acid-fast bacilli were histologically confirmed in all 8 patients. Culture of excised nodules revealed Mycobacterium intracellulare in 5 patients and Mycobacterium avium in 3 patients. Six patients received PET, and median SUVmax was: 7.0 (range: 3.3-21.0). Median VDT was around 200 days. Some patients had irregular-shaped nodules. Conclusions: CT/PET-CT characteristics of lung nodules are not reliable in differentiating lung NTM nodules from malignant ones. To avoid unnecessary resection, it may be better to collect various information on imaging findings in the nodule itself and in opacities other than the nodule.

show abstract

Preoperative nutritional evaluation of prostate cancer patients undergoing laparoscopic radical prostatectomy

Wang

et al. 2022

PLoS ONE

View full text Add to dashboard Cite

Background and objective Prostate cancer (PCa) is one of the most common malignant tumors in men. Geriatric Nutritional Risk Index (GNRI) is an objective index for evaluating nutritional status of elderly people over 65 years old. The aim of the current study was to explore the correlation and predictive value between GNRI and postoperative recovery and complications in PCa patients undergoing laparoscopic radical prostatectomy (LRP). Methods Taking 98 as the GNRI boundary value, 96 PCa patients (aged≥65 y) undergoing LRP in the Department of Urology, Affiliated Hospital of North Sichuan Medical College from January 2018 to December 2020 were grouped into malnutrition group (MNg, 34 patients, 35.4%) and normal nutrition group (NNg, 62 patients, 64.6%). Basic information, laboratory examination indexes, operation conditions, postoperative complications and postoperative recovery indexes of patients were recorded and retrospectively analyzed. Clavien-Dindo Classification System (CDCS) was used to assess postoperative complications. T-test was used to analyze differences between the two groups. ROC curve was generated to determine the predictive value of GNRI for postoperative complications. Results Percentage of complications was significantly higher in MNg group compared with that in NNg group (P < 0.01). The average grade based on CDCS was significantly lower in NNg group compared with that in MNg group (P < 0.01). Body weight, Body Mass Index (BMI), preoperative hemoglobin value (HGB), serum albumin (ALB) values of MNg and NNg were significantly positively correlated with GNRI (P<0.01). Incidence and severity of postoperative complications of MNg patients were significantly higher compared with those of NNg patients (P<0.05). Average hospitalization cost of MNg patients was higher in MNg patients compared with that of NNg patients (P<0.05). Duration of post-anesthesia care unit (PACU), duration of antibiotic use and duration of indwelling drainage tube were longer in MNg patients compared with those in NNg patients (P<0.05). Furthermore, volume of indwelling drainage tube was higher in MNg patients compared with that in NNg patients (P<0.05). Conclusion GNRI is an effective and reliable tool for evaluation of preoperative nutritional status of prostate cancer patients. The findings showed that GNRI is correlated with postoperative recovery and complications, and is an effective predictive marker.

show abstract

When occam's razor can fail– active mycobacteria infection and lung cancer: A case of neuroendocrine lung cancer diagnosed in the setting of refractory mycobacterium avium‐intracellulare

Cited by 4 publications

References 7 publications

Clinical significance of changes in serum inflammatory factors in patients with chronic obstructive pulmonary disease and pulmonary infection

Clinical significance of changes in serum inflammatory factors in patients with chronic obstructive pulmonary disease and pulmonary infection

Imaging characteristics of nontuberculous mycobacterial pulmonary nodules

Preoperative nutritional evaluation of prostate cancer patients undergoing laparoscopic radical prostatectomy

Contact Info

Product

Resources

About