When sneezing indicates the cell type

Gelardi, Matteo; Quaranta, Nicola; Passalacqua, Giovanni

doi:10.1002/alr.21119

Cited by 10 publications

(10 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…has been identified as the main cause of atopic and allergy in the tropics, 4 , 11 we observed that the frequency of positive NsIgE in the RWoA group (n = 12, 48%) was similar to in the control group (n = 5, 27.8%), and most of these patients had a negative challenge. These results support the previous data of Gelardi et al, 38 who observed NsIgE in 50% of a healthy group, and suggested that the production of NsIgE may represent a form of spontaneous immune response and is not a specific finding of nasal symptoms.…”

Section: Discussionsupporting

confidence: 92%

Nasal specific IgE to Der p is not an acceptable screening test to predict the outcome of the nasal challenge test in patients with non-allergic rhinitis

Santamaría

Calle

Biol

et al. 2020

World Allergy Organization Journal

View full text Add to dashboard Cite

Objectives Nasal specific IgE (NsIgE) is the most common marker to identify type-2 inflammation in local allergic rhinitis (LAR). However, the comparison of NsIgE in different types of rhinitis, its frequency in tropical countries, and its diagnostic performance for predicting the outcome of a nasal challenge test (NCT) has had limited study. The main objective of this study was to explore the diagnostic performance of NsIgE to Dermatophagoides pteronyssinus (Der p) among different types of rhinitis and control subjects in a tropical population. Methods We evaluated the frequency of NsIgE, systemic atopy (serum sIgE and Skin Prick Test), and nasal eosinophils, and we performed nasal challenge tests (NCTs) with Der p in 3 groups of patients; rhinitis without atopy (RWoA) (n = 25), rhinitis with atopy (RWA) (n = 25), and control subjects (n = 18). Results NsIgE had a low sensitivity and specificity to predict a positive NCT in the RWoA group: 48% had NsIgE, but only 28% had a positive NCT. Among the RWA group 84% had NsIgE and 80% had a positive NCT; the association of NsIgE and positive NCT was high (>80%). In the control group 27.8% had NsIgE, but none had a positive NCT. Conclusions NsIgE performs poorly in predicting NCT results in patients with non-allergic rhinitis. More methodical investigations are needed in this complex area of rhinitis. In patients with allergic rhinitis, NsIgE was useful in predicting a positive nasal challenge, but not superior to the systemic atopic test.

show abstract

Section: Discussionsupporting

confidence: 92%

Nasal specific IgE to Der p is not an acceptable screening test to predict the outcome of the nasal challenge test in patients with non-allergic rhinitis

Santamaría

Calle

Biol

et al. 2020

World Allergy Organization Journal

View full text Add to dashboard Cite

show abstract

“…It can be argued that the aforementioned studies on LAR suffered from a relatively low specificity. The allergen nasal provocation test implies the administration of allergens at high concentration, that can provoke a non specific response expecially in NAR where the nasal mucosa is already inflamed [22]. Also, acoustic rhinometry is now considered poorly reproducible and difficult to standardize [23].…”

Section: Discussionmentioning

confidence: 99%

LOCAL Allergic Rhinitis: Entopy or Spontaneous Response?

Gelardi

Guglielmi

Iannuzzi

et al. 2016

Journal of Allergy and Clinical Immunology

Self Cite

View full text Add to dashboard Cite

Background: The existence of a local allergic rhintis was proposed on the basis of the detection of nasal IgE in the absence of a systemic sensitization. Nevertheless, the significance of this phenomenon remains still unclear.We assessed the presence of mucosal nasal IgE in patients with ascertained allergic rhinitis, nonallergic rhinitis with inflammation and in healthy controls. Methods: Consecutive patients with a well ascertained diagnosis (clinical history, skin prick test, specific IgE assay, nasal endoscopy, nasal cytology) underwent an immunoenzymatic measurement of specific IgE to grass, cypress, parietaria and olive in nasal scrapings.

show abstract

“…6,7,8,9 Based on the above considerations, it seems to be clear that nasal cytology (NC) can be an eff ective and easy-to-apply diagnostic and prognostic tool in the management of rhinitis, as it allows to detect and measure the cell population at the nasal level. 10,11 Moreover, NC is helpful to discriminate diff erent nasal disorders, to evaluate the impact of diff erent stimuli on the nose, including allergens, microbes, physical and chemical agents, and pharmacological molecules, as well as to document the eff ect of treatments. The methodology is easy and well standardized, and it mainly involves sampling, staining, and interpretation.…”

Section: Introductionmentioning

confidence: 99%

The pragmatic role of nasal cytology: a point-of-care testing to implement precision medicine in clinical practice

Gelardi¹,

Landi²,

Ciprandi³

2018

RAM

Self Cite

View full text Add to dashboard Cite

show abstract

When sneezing indicates the cell type

Abstract: The onset of hyperreactivity (sneezing) can be considered an important "sign" in nasal symptomatology, whose sensitivity and specificity for nonallergic "cellular" rhinitis are 79% and 93%, respectively.

Cited by 10 publications

References 18 publications

Nasal specific IgE to Der p is not an acceptable screening test to predict the outcome of the nasal challenge test in patients with non-allergic rhinitis

Nasal specific IgE to Der p is not an acceptable screening test to predict the outcome of the nasal challenge test in patients with non-allergic rhinitis

LOCAL Allergic Rhinitis: Entopy or Spontaneous Response?

The pragmatic role of nasal cytology: a point-of-care testing to implement precision medicine in clinical practice

Contact Info

Product

Resources

About