When there is only one patient: Induction of labour for termination of pregnancy

Costescu, Dustin; Mui, Carween

doi:10.1016/j.bpobgyn.2021.11.001

Cited by 3 publications

(2 citation statements)

References 31 publications

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“…The study showed that first‐trimester vacuum aspiration was more effective, shorter in duration and resulted in less bleeding and pain compared to medical termination with prostaglandin. Costescu and Mui 11 focused on first‐ and second‐trimester surgical termination and the respective complication rates. They reported an increase in the frequency of complications with advancing gestational age.…”

Section: Discussionmentioning

confidence: 99%

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Complication rate after termination of pregnancy for fetal defects

Spingler

Sonek

Hoopmann

et al. 2023

Ultrasound in Obstet & Gyne

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The morbidity of pregnancy termination for fetal defects is significantly lower if carried out in the first compared with the second or third trimester. What are the clinical implications of this work?The findings of this study amount to a plea for detailed examination of fetal anatomy in the first trimester. If an anomaly is detected later in pregnancy and results in termination, the risk of associated complications is much higher.

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Section: Discussionmentioning

confidence: 99%

“…The standard protocol for induction of labor includes administration of 200 μg mifepristone, followed by 400 μg misoprostol (200 μg vaginally and 200 μg orally, at the same time) 24 h later [10][11][12][13][14] . In the third trimester, the dose of misoprostol is reduced to 200 μg.…”

Section: Methodsmentioning

confidence: 99%

Complication rate after termination of pregnancy for fetal defects

Spingler

Sonek

Hoopmann

et al. 2023

Ultrasound in Obstet & Gyne

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Optimal timing of labour induction in contemporary clinical practice

Papalia

D’Souza

Hobson

2022

Best Practice & Research Clinical Obstetrics & Gynaecol

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Effect of Mifepristone Preconditioning on Stress Response and Sex Hormone Levels after Combined Laparoscopic Treatment for Cesarean Scar Pregnancy: A Prospective Randomized Trial

Chen,

Peng,

Shou

et al. 2023

Clin. Exp. Obstet. Gynecol.

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Background: This study aimed to explore the effect of mifepristone pretreatment on stress response and sex hormone levels after combined laparoscopic treatment for cesarean scar pregnancy. Methods: We conducted a prospective, randomized, controlled study from January 2020 to September 2022. A total of 98 pregnant women with cesarean scar pregnancy were included and divided into two groups by the random number table method. The control group received hysteroscopy combined with laparoscopy treatment, and the observation group received mifepristone pretreatment before hysteroscopy, combined with laparoscopy treatment. The surgical efficacy, surgical indices, menstrual recovery time, postoperative residual muscle layer, and scar morphology were observed and evaluated. The ovarian hemodynamic indices, stress indices, and sex hormone levels were measured, and the incidence of complications such as postoperative infection and liver function impairment was calculated. Results: There was no significant difference in the surgical success rate between the two groups (97.96% vs 95.92%), as well as the thickness and proportion of residual muscle layer, the width, length, and depth of scars, and the incidence of postoperative complications (p > 0.05). Combined mifepristone pretreatment reduced intraoperative bleeding, shortened the average time for beta human chorionic gonadotropin (β-hCG) to fall to negative (20.5 days, p < 0.05) and vaginal bleeding (19.8 days, p < 0.05), lowered Vmax (49.8 cm/s, p < 0.05), and elevated resistance index (RI) (0.7, p < 0.05) and pulsatility index (PI) (2.5, p < 0.05). Moreover, combined mifepristone pretreatment reduced C-reactive protein (CRP: 8.1 mg/L, p < 0.05), cortisol (COR: 21.7 mg/L, p < 0.05), adrenocorticotropic hormone (ACTH: 40.2 ng/L, p < 0.05), as well as progesterone (P: 10.2 mmol/L, p < 0.05), luteinizing hormone (LH: 13.2 µg/L, p < 0.05), and follicle-stimulating hormone (FSH: 14.8 µg/L, p < 0.05). Combined mifepristone pretreatment promoted the recovery of menstruation (25 days, p < 0.05). Conclusion: Mifepristone pretreatment can promote postoperative recovery, reduce postoperative stress response, improve hemodynamics, regulate sex hormone levels, and promote the early recovery of menstruation in patients with cesarean scar pregnancy. Clinical Trial Registration: The study was registered at Chinese Clinical Trial Registry (https://www.chictr.org.cn), registration number: ChiCTR1800015514.

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When there is only one patient: Induction of labour for termination of pregnancy

Cited by 3 publications

References 31 publications

Complication rate after termination of pregnancy for fetal defects

Complication rate after termination of pregnancy for fetal defects

Optimal timing of labour induction in contemporary clinical practice

Effect of Mifepristone Preconditioning on Stress Response and Sex Hormone Levels after Combined Laparoscopic Treatment for Cesarean Scar Pregnancy: A Prospective Randomized Trial

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