Where are the opportunities for an earlier diagnosis of primary intracranial tumours in children and young adults?

Chu, Thomas P. C.; Shah, Anjali; Walker, David; Coleman, Michel P

doi:10.1016/j.ejpn.2016.10.010

Cited by 11 publications

(7 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…763 studies were initially identified, of which 28 were included in the final review ( Fig. 2 ) [10] , [11] , [12] , [15] , [16] , [17] , [18] , [19] , [20] , [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] . All but four of the selected studies were carried out in Denmark or the UK, while the four remaining studies were set in Germany, Sweden, Australia, and the Netherlands.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Does changing healthcare use signal opportunities for earlier detection of cancer? A review of studies using information from electronic patient records

White

Renzi

Rafiq

et al. 2022

Cancer Epidemiology

View full text Add to dashboard Cite

Background It has been proposed that changes in healthcare use before cancer diagnosis could signal opportunities for quicker detection, but systematic appreciation of such evidence is lacking. We reviewed studies examining pre-diagnostic changes in healthcare utilisation (e.g. rates of GP or hospital consultations, prescriptions or diagnostic tests) among patients subsequently diagnosed with cancer. Methods We identified studies through Pubmed searches complemented by expert elicitation. We extracted information on the earliest time point when diagnosis could have been possible for at least some cancers, together with variation in the length of such ‘diagnostic windows’ by tumour and patient characteristics. Results Across twenty-eight studies, changes in healthcare use were observable at least six months pre-diagnosis for many common cancers, and potentially even earlier for colorectal cancer, multiple myeloma and brain tumours. Early changes were also identified for brain and colon cancer sub-sites. Conclusion Changing healthcare utilisation patterns before diagnosis indicate that future improvements in diagnostic technologies or services could help to shorten diagnostic intervals for cancer. There is greatest potential for quicker diagnosis for certain cancer types and patient groups, which can inform priorities for the development of decision support tools.

show abstract

Section: Resultsmentioning

confidence: 99%

“…For brain tumours, window lengths varied by anatomic subsite (e.g. the supratentorial compartment, the midline, or cranial nerves) [21] , and for some presenting symptoms (e.g. headache and convulsions), although patterns were complex [24] .…”

Section: Resultsmentioning

confidence: 99%

Does changing healthcare use signal opportunities for earlier detection of cancer? A review of studies using information from electronic patient records

White

Renzi

Rafiq

et al. 2022

Cancer Epidemiology

View full text Add to dashboard Cite

show abstract

“…However, studies in children and young adults with CNS tumors have found increased health care use from 6 and 17 months before diagnosis, respectively. 31 , 11 Yet, neither of these studies accounted for differences between benign and malignant tumors. Even so, our findings of increased health care use for patients with benign primary intracranial tumors for up to 2 years before diagnosis indicate that the possibility for an earlier diagnosis in adult patients with benign primary intracranial tumors may be larger than the window of opportunity found in children and young adults with CNS tumors.…”

Section: Discussionmentioning

confidence: 97%

Health care use before a diagnosis of primary intracranial tumor: a Danish nationwide register study

Nygaard

Jensen

Christensen

et al. 2018

CLEP

View full text Add to dashboard Cite

IntroductionDetailed knowledge of prediagnostic health care use among patients with primary intracranial tumors is sparse. We aimed to investigate the health care use among adults during the 2 years preceding a diagnosis of a benign or malignant primary intracranial tumor in Denmark.MethodsWe conducted a population-based matched cohort study using historical data from Danish nationwide registries, including all patients aged 30–90 years diagnosed with a first-time primary intracranial tumor from January 1, 2009 to December 31, 2014, and with no prior cancer diagnosis (n=5,926). For each patient, ten comparison subjects were identified using density sampling. We analyzed differences in the frequency and timing of health care use within general practice, physiotherapy, radiology, ear –nose –throat, ophthalmology, neurology, and psychiatry. Odds ratios of having multiple contacts were calculated using a conditional logistical regression model. Monthly incidence rate ratios were estimated using a negative binomial regression model.ResultsOf all patients, 62% had a benign tumor. Patients with benign tumors were more likely to have multiple consultations with health care providers in the period 2–12 months prior to diagnosis and to have increased rates of consultations 1–24 months prior to diagnosis, depending on health service.ConclusionPatients diagnosed with a benign or a malignant primary intracranial tumor use the health care services differently. Increased health care use is seen within relatively close proximity to the diagnosis for patients with malignant tumors. However, patients with benign tumors have increased health care use from up to 2 years prior to diagnosis; this suggests a window of opportunity for earlier diagnosis.

show abstract

“…[2][3][4][5] We therefore have recommended persistence or recurrence of symptoms, instead of emergence of confirmatory features that may not be present until a tumor has reached an advanced state, as a more useful trigger for further investigations. 2,6 Delays in diagnosing an intracranial tumor result in patient distress and parental anxiety, and may lead to lengthy disputes with health care professionals. Parents' reactions to the eventual diagnosis are often very negative, especially when earlier opportunities exist for which a diagnosis could have been made.…”

mentioning

confidence: 99%

“…2 –5 We therefore have recommended persistence or recurrence of symptoms, instead of emergence of confirmatory features that may not be present until a tumor has reached an advanced state, as a more useful trigger for further investigations. 2,6…”

mentioning

confidence: 99%

How Do Biological Characteristics of Primary Intracranial Tumors Affect Their Clinical Presentation in Children and Young Adults?

et al. 2018

Self Cite

View full text Add to dashboard Cite

We demonstrated the pattern in presentation of primary intracranial tumors in a population-based cohort of patients aged 0-24 years identified from the National Cancer Registry for England, using linked medical records from primary care and hospitals. We used generalized additive models to estimate temporal changes in presentation rates. Borderline and malignant tumors presented at a similar rate in primary care (6.4 and 6.6 consultations per 100 patients each month) and in hospital (3.4 and 3.6). Benign tumors presented earlier but less frequently (rate = 4.4 and rate ratio = 0.75, 95% CI = 0.60-0.93, in primary care; rate = 2.6 and rate ratio = 0.83, 95% CI = 0.77-0.89, in hospital). Many tumors began presenting shortly before their diagnosis, but less aggressive tumors were likely to present earlier in primary care. Earlier detection of less aggressive tumors in primary care may reduce the risk of complications and morbidity among survivors.

show abstract

Where are the opportunities for an earlier diagnosis of primary intracranial tumours in children and young adults?

Cited by 11 publications

References 22 publications

Does changing healthcare use signal opportunities for earlier detection of cancer? A review of studies using information from electronic patient records

Does changing healthcare use signal opportunities for earlier detection of cancer? A review of studies using information from electronic patient records

Health care use before a diagnosis of primary intracranial tumor: a Danish nationwide register study

How Do Biological Characteristics of Primary Intracranial Tumors Affect Their Clinical Presentation in Children and Young Adults?

Contact Info

Product

Resources

About