Where Do We Go From Here: Reflections on a Century in Women’s Cardiovascular Health Research, 1924–2024

Bello, Natalie A.; Cheng, Susan

doi:10.1161/circresaha.123.323182

Circulation Research

2024

DOI: 10.1161/circresaha.123.323182

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Where Do We Go From Here: Reflections on a Century in Women’s Cardiovascular Health Research, 1924–2024

Natalie A. Bello,

Susan Cheng

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2024

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Cited by 2 publications

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Sex-related differences in the 20-year incidence of CVD and its risk factors: The ATTICA study (2002–2022)

Sigala,

Vaina,

Chrysohoou

et al. 2024

American Journal of Preventive Cardiology

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Sex-related differences in the 20-year incidence of CVD and its risk factors: The ATTICA study (2002–2022)

Sigala,

Vaina,

Chrysohoou

et al. 2024

American Journal of Preventive Cardiology

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Transgenic rat with ubiquitous expression of angiotensin-(1-7)-producing fusion protein: a new tool to study the role of protective arm of the renin-angiotensin system in the pathophysiology of cardio-renal diseases

Červenka,

Husková,

Kikerlová

et al. 2024

Hypertens Res

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The aim of the present study was to assess systemic circulatory and tissue activities of both the classical arm and of the alternative arm of the renin-angiotensin system (RAS) in a new transgenic rat line (TG7371) that expresses angiotensin-(1-7) (ANG 1-7)-producing fusion protein; the results were compared with the activities measured in control transgene-negative Hannover Sprague-Dawley (HanSD) rats. Plasma and tissue concentrations of angiotensin II (ANG II) and ANG 1-7, and kidney mRNA expressions of receptors responsible for biological actions of ANG II and ANG 1-7 [i.e. ANG II type 1 and type 2 (AT1 and AT2) and Mas receptors] were assessed in TG7371 transgene-positive and in HanSD rats. We found that male TG7371 transgene-positive rats exhibited significantly elevated plasma, kidney, heart and lung ANG 1-7 concentrations as compared with control male HanSD rats; by contrast, there was no significant difference in ANG II concentrations and no significant differences in mRNA expression of AT1, AT2 and Mas receptors. In addition, we found that in male TG7371 transgene-positive rats blood pressure was lower than in male HanSD rats. These data indicate that the balance between the classical arm and the alternative arm of the RAS was in male TGR7371 transgene-positive rats markedly shifted in favor of the latter. In conclusion, TG7371 transgene-positive rats represent a new powerful tool to study the long-term role of the alternative arm of the RAS in the pathophysiology and potentially in the treatment of cardio-renal diseases.

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Where Do We Go From Here: Reflections on a Century in Women’s Cardiovascular Health Research, 1924–2024

Cited by 2 publications

References 23 publications

Sex-related differences in the 20-year incidence of CVD and its risk factors: The ATTICA study (2002–2022)

Sex-related differences in the 20-year incidence of CVD and its risk factors: The ATTICA study (2002–2022)

Transgenic rat with ubiquitous expression of angiotensin-(1-7)-producing fusion protein: a new tool to study the role of protective arm of the renin-angiotensin system in the pathophysiology of cardio-renal diseases

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