Which anti-nausea medications are more likely to increase QTc interval?

Abstract

Which anti-nausea medications are more likely to increase QTc interval? EVIDENCE-BASED ANSWEROndansetron, haloperidol, and aprepitant have little effect on the QTc interval, whereas droperidol prolongs QTc compared with placebo (SOR: B, metaanalysis of low-quality studies). Dolasetron combined with dexamethasone significantly increases risk of QTc prolongation compared to ondansetron combined with dexamethasone (SOR: B, systemic review). A single dose of ondansetron 8 mg is associated with transient QTc prolongation when compared to 4 mg (SOR: B, single randomized controlled trial).