Which Antibiotics Should be First Line Options for Empirical Treatment of Urinary Tract Infections During Pregnancy?

Aşgın, Nergis; Eroğlu, Semra; Çakmaklıoğulları, Elçin Kal

doi:10.5222/ankem.2018.1820

Cited by 2 publications

(10 citation statements)

References 19 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, among 1710 urine samples cultured from asymptomatic pregnant women, 123 samples yielded uropathogens, showing a prevalence of 7.2%. This is consistent with the prevalence of ABU seen in other studies by Aktun et al ( 2), Tokak et al ( 5), and Aşgın et al (6), respectively, 7.1%, 7.8%, and 10%. The occurrence of significant bacteria in the lower urinary tract with no symptoms makes the condition more susceptible in pregnant women.…”

Section: Discussionsupporting

confidence: 92%

“…These factors lead to urinary stasis, dysfunctional urethral valves, and vesicoureteral reflux that assists bacterial colonization (16). Several studies have reported that the geographic variability of pathogens in the case of ABU is limited with the predominance of gram-negative, particularly E. coli (2,5,6,17,18). We also detected gram-negative isolates as the causative agent at a higher rate, 67.5%.…”

Section: Discussionmentioning

confidence: 53%

“…In the study of Aktun et al (2), ampicillin resistance was 46%, cefuroxime resistance was 15%, ceftriaxone resistance was 10%, and nitrofurantoin resistance was 6.3%, while fosfomycin resistance was found below 1% in E. coli strains. In the study of Aşgın et al (6), ampicillin resistance of E. coli isolates was 53%, and cefuroxime resistance was 18%, while fosfomycin resistance was 3%.…”

Section: E a R L Y A C C E S Smentioning

confidence: 95%

“…The most commonly isolated bacteria in ABU are Escherichia coli (E. coli) and some other bacteria including Enterobacteriaceae, Streptococcus agalactiae (S. agalactiae), Pseudomonas aeruginosa, Enterococcus spp. and Staphylococcus aureus may cause ABU among pregnant women, while the isolated bacteria widely vary according to geographical areas (1,2,5,6). Studies have reported that ABU during pregnancy increases the risk of developing pyelonephritis and obstetric outcomes that may result in adverse events such as premature delivery and low birth weight (7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Comparison of Asymptomatic Bacteriuria Agents and Antimicrobial Susceptibility in Term and Preterm Pregnancies

Aydın

GÜNEY²,

Emecen

et al. 2022

Düzce Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

Amaç: Bu çalışmanın amacı, asemptomatik bakteriüri (ASB) etkenlerinin direnç paternlerini term ve preterm gebelikler arasında karşılaştırmaktır. Gereç ve Yöntemler: Hastanemiz kadın doğum bölümünde takip edilen ve idrar kültürleri laboratuvarda incelenmek üzere gönderilen ve ASB olarak rapor edilen 17-41 yaş arası gebeler çalışmaya dahil edildi. Hastalar gebelik haftalarına göre preterm (<37 hafta) ve term (≥37 hafta) olmak üzere iki gruba ayrıldı. Sonuçlar iki grup arasında karşılaştırıldı. Bulgular: Toplam 123 gebeden 29'u (%23,6) preterm, 94'ü (%76,4) term doğum yaptı. Tüm çalışma grubunda en sık izole edilen patojen %52,0 (n=64) ile Escherichia coli (E. coli) idi ve bunu %16,3 (n=20) ile Streptococcus agalactiae (S.agalactiae) izlemekteydi. Term ve preterm grupları arasında E. coli ve S. agalactiae dağılımı açısından istatistiksel olarak anlamlı bir fark yoktu (p=0,698 ve p=0,930). E. coli suşları ampisiline %56,3 (n=36) oranında, sefuroksime %40,6 (n=26) oranında dirençliydi. Fosfomisin direnci %1,6 (n=1) olarak belirlenirken, nitrofurantoin direnci saptanmadı. E. coli suşlarında genişletilmiş spektrumlu beta-laktamaz pozitifliği %23,4 (n=15) olarak tespit edildi. Term ve preterm grupları arasında E. coli suşlarının antibiyotik direnç oranları bakımından istatistiksel olarak anlamlı fark saptanmadı. Sonuç: En sık izole edilen patojen bakteri, beta laktamlara oldukça dirençli olan E. coli idi. Gebelerin ASB için taranması ve uygun antibiyoterapi ile tedavisi; maternal ve fetüste gelişecek komplikasyonları ve antimikrobiyal direnci önlemede etkili bir yoldur.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 53%

Section: E a R L Y A C C E S Smentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Comparison of Asymptomatic Bacteriuria Agents and Antimicrobial Susceptibility in Term and Preterm Pregnancies

Aydın

GÜNEY²,

Emecen

et al. 2022

Düzce Tıp Fakültesi Dergisi

View full text Add to dashboard Cite

show abstract

“…The increase in uterine dimensions with pregnancy, facilitates urinary tract infections by causing stasis in the dilatation of urinary flow in the ureter and bladder with the effect of progesterone. Glucosuria, urine osmolality and changes in urine pH during pregnancy are also factors that predispose to urinary tract infections (2,3).…”

Section: Introductionmentioning

confidence: 99%

Determination of antibiotic resistance rates of Escherichia coli and Klebsiella pneumoniae isolates, which are the causative agents of urinary tract infection in pregnant women

AYDOĞMUŞ¹,

Kılıç²

2023

Anatolian Current Medical Journal

View full text Add to dashboard Cite

Aim: Urinary tract infections are common infections during pregnancy. Infections seen during pregnancy have a spectrum ranging from asymptomatic bacteriuria to cystitis, pyelonephritis and, urosepsis. In this study, it was aimed to determine the antibiotic resistance rates of Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) isolates isolated from urinary cultures of pregnant women who applied to the Ankara Training and Research Hospital. Material and Method: The identification and antibiotic susceptibility of E. coli and K. pneumoniae isolates isolated from urinary samples of pregnant women who applied to the Ankara Training and Research Hospital between January 2021 and December 2022 were investigated with VITEK-2 (Biomerioux, France) fully automated system, and the presence of extended-spectrum beta-lactamase (ESBL) was investigated by combined disc diffusion method. The obtained data were analysed retrospectively. Results: Bacterial growth was detected in 1090 (1.2%) out of a total of 8923 urine samples over a two-year period. 480 (4.4%) of the microbial agents reproducing in urine culture were E. coli and 105 (0.96%) were K. pneumoniae. The rate of extended-spectrum beta-lactamase (ESBL) in E. coli strains was 16.04% (77/480), and the rate of ESBL in K. pneumoniae strains was 20.9% (22/105). Resistance rates of amoxicillin-clavulanic acid, ceftriaxone, phosphomycin, ciprofloxacin, piperacillin-tazobactam, nitrofurantoin, imipenem, meropenem, ertapenem in ESBL negative E. coli strains were 15.9%, 8.82%, 20%, 11.1%, 5.88%, 0%, 0%, 0% and 0%, respectively. Resistance rates of amoxicillin-clavulanic acid, ceftriaxone, phosphomycin, ciprofloxacin, piperacillin-tazobactam, nitrofurantoin, imipenem, meropenem, ertapenem in ESBL positive E. coli strains were determined as 66.5%, 100%, 2.2%, 33.8%, 11.5%, 0%, 0%, 0% and, 0%, respectively. Resistance rates of amoxicillin-clavulanic acid, ceftriaxone, phosphomycin, ciprofloxacin, piperacillin-tazobactam, nitrofurantoin, imipenem, meropenem, ertapenem in ESBL negative K. pneumoniae strains were 53%, 100%, 12.5%, 28.5%, 2.2%, 3.5%, 0%, 0% and, 4.5%, respectively. Resistance rates of amoxicillin-clavulanic acid, ceftriaxone, phosphomycin, nitrofurantoin, ciprofloxacin, piperacillin-tazobactam, imipenem, meropenem, ertapenem in ESBL positive K. pneumoniae strains were 62.5%, 100%, 12.5%, 35%, 28.5%, 22.7%, 0%, 0% and, 4.5%, respectively. Conclusion: According to the antibiotic susceptibility data in our hospital, phosphomycin or carbapenems may be preferred due to the low resistance rate in the empirical treatment of E. coli-related urinary tract infections in pregnant women. In the treatment of urinary tract infections due to K. pneumoniae, phosphomycin, piperacillin-tazobactam or carbapenems may be preferred due to low resistance rates.

show abstract

Which Antibiotics Should be First Line Options for Empirical Treatment of Urinary Tract Infections During Pregnancy?

Cited by 2 publications

References 19 publications

Comparison of Asymptomatic Bacteriuria Agents and Antimicrobial Susceptibility in Term and Preterm Pregnancies

Comparison of Asymptomatic Bacteriuria Agents and Antimicrobial Susceptibility in Term and Preterm Pregnancies

Determination of antibiotic resistance rates of Escherichia coli and Klebsiella pneumoniae isolates, which are the causative agents of urinary tract infection in pregnant women

Contact Info

Product

Resources

About