Which factors can affect cord blood variables?

Bonab, M.A. Mohyeddin; Alimoghaddam, Kamran; Goliaei, Z.A.; Ghavamzadeh, Ardeshir

doi:10.1111/j.1537-2995.2004.03227.x

Cited by 26 publications

(20 citation statements)

References 21 publications

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“…As described by others [16], [24], [26], maternal age had no impact on the HSPC concentration. In contrast, other groups reported an influence of maternal age on HSPC concentration, which is in line with our results [19], [27]. In addition, the univariate analysis shows a maternal age-dependent influence on the clonogenic capacity.…”

Section: Discussionsupporting

confidence: 92%

Hematopoietic Stem Cells in Neonates: Any Differences between Very Preterm and Term Neonates?

et al. 2014

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BackgroundIn the last decades, human full-term cord blood was extensively investigated as a potential source of hematopoietic stem and progenitor cells (HSPCs). Despite the growing interest of regenerative therapies in preterm neonates, only little is known about the biological function of HSPCs from early preterm neonates under different perinatal conditions. Therefore, we investigated the concentration, the clonogenic capacity and the influence of obstetric/perinatal complications and maternal history on HSPC subsets in preterm and term cord blood.MethodsCD34+ HSPC subsets in UCB of 30 preterm and 30 term infants were evaluated by flow cytometry. Clonogenic assays suitable for detection of the proliferative potential of HSPCs were conducted. Furthermore, we analyzed the clonogenic potential of isolated HSPCs according to the stem cell marker CD133 and aldehyde dehydrogenase (ALDH) activity.ResultsPreterm cord blood contained a significantly higher concentration of circulating CD34+ HSPCs, especially primitive progenitors, than term cord blood. The clonogenic capacity of HSPCs was enhanced in preterm cord blood. Using univariate analysis, the number and clonogenic potential of circulating UCB HSPCs was influenced by gestational age, birth weight and maternal age. Multivariate analysis showed that main factors that significantly influenced the HSPC count were maternal age, gestational age and white blood cell count. Further, only gestational age significantly influenced the clonogenic potential of UCB HSPCs. Finally, isolated CD34+/CD133+, CD34+/CD133– and ALDHhigh HSPC obtained from preterm cord blood showed a significantly higher clonogenic potential compared to term cord blood.ConclusionWe demonstrate that preterm cord blood exhibits a higher HSPC concentration and increased clonogenic capacity compared to term neonates. These data may imply an emerging use of HSPCs in autologous stem cell therapy in preterm neonates.

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Section: Discussionsupporting

confidence: 92%

Hematopoietic Stem Cells in Neonates: Any Differences between Very Preterm and Term Neonates?

et al. 2014

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“…In our study, the CB units from male babies had a high fraction of CD34+ cells/TNCs (p = 0.007); thus, CD34+ cells showed no difference according to neonate sex, although the number of TNCs was lower in males (p < 0.001). The finding that TNCs and CD34+ cells are correlated with the CB volume, gestational age, and birth weight is consistent with previous studies 9,10,13‐15,19 . CD34+ cells/TNCs showed a positive correlation with the CB volume and birth weight and a negative correlation with gestational age.…”

Section: Discussionsupporting

confidence: 92%

“…Many studies have been reported regarding the maternal and neonatal factors that could affect hematopoietic variables of CB units such as TNCs and CD34+ cells 9‐16 . To advance the CB banking process in Korea, which comprises a unique population different from western countries, 17 the impact of maternal and neonatal factors on hematopoietic variables of CB should be clarified.…”

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confidence: 99%

Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population

et al. 2011

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“…Our results confirm the relationship between infant and placental weight and cord blood volume and cell content, a finding also reported by others [6,16,17,18,19]. In fact, placental weight was the only variable that independently influenced volume, TNC, CD34+ cells and CFU content of collections.…”

Section: Discussionsupporting

confidence: 80%

Maternal, Neonatal and Collection Factors Influencing the Haematopoietic Content of Cord Blood Units

Solves¹,

Perales

Moraga

et al. 2005

Acta Haematol

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Background and Objectives: Umbilical cord blood (UCB) contains haematopoietic stem cells and can be used as an alternative to bone marrow transplantation in certain cases. Engraftment was dependent upon the haematopoietic progenitor cell content of the cord blood units. This study was designed to investigate the influence of obstetric, neonatal and collection factors on the volume and haematopoietic content of UCB donations. Material and Methods: A retrospective analysis of obstetric and neonatal factors was performed from 300 cord blood donations in Valencia Cord Blood Bank. Maternal, neonatal and collection factors influencing cord blood quality measured as volume, total nucleated cell count, CD34+ cells and colony-forming units (CFU) were analysed. Results: Bigger babies produced cord blood units with larger volume, higher cells counts, CFU and CD34 cell counts. In the multivariate analysis, we found that both placental weight and mode of collection were predictor variables for total nucleated cell count, CD34 cells and CFU. Conclusion: Our study concludes that cord blood units must be collected before placental delivery and that birth weight, as an estimation of the placental weight, could be added to standard cord blood donors criteria in order to improve the bank efficiency.

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Which factors can affect cord blood variables?

Abstract: Our data indicates that VD and heavier babies showed significant increase in TNC by multiple regression analysis. However, r(2)= 0.07 and even when all factors were considered, r(2)= 0.16, which is a percentage too insignificant to be applied for ideal CB screening.

Cited by 26 publications

References 21 publications

Hematopoietic Stem Cells in Neonates: Any Differences between Very Preterm and Term Neonates?

Hematopoietic Stem Cells in Neonates: Any Differences between Very Preterm and Term Neonates?

Increased numbers of total nucleated and CD34+ cells in blood group O cord blood: an analysis of neonatal innate factors in the Korean population

Maternal, Neonatal and Collection Factors Influencing the Haematopoietic Content of Cord Blood Units

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