Which is the best method in clinical practice for assessing improvement in vascular endothelial function after successful smoking cessation — Flow-mediated dilation (FMD) or reactive hyperemic peripheral arterial tonometry (RH-PAT)?

Kato, Toru

doi:10.1038/s41440-020-00565-2

Cited by 4 publications

(2 citation statements)

References 7 publications

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“…A properly functioning endothelium is considered one of the best indicators of vascular health, whereas endothelial dysfunction may lead to CVD progression [ 81 , 82 ]. Several measurements can be used to assess the endothelial function, with brachial artery flow-mediated dilation (FMD) and reactive hyperemia–peripheral arterial tonometry (RH-PAT) being the two most rapidly used methods in clinical research [ 83 ].…”

Section: Randomized Controlled Trials On Carotenoids and Cvdsmentioning

confidence: 99%

The Roles of Carotenoid Consumption and Bioavailability in Cardiovascular Health

2021

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Carotenoids are natural pigments generally with a polyene chain consisting of 9–11 double bonds. In recent years, there has been increasing research interest in carotenoids because of their protective roles in cardiovascular diseases (CVDs). While the consumption of carotenoids may have a beneficial effect on CVDs, the literature shows inconsistencies between carotenoid consumption and reductions in the risk of CVDs. Therefore, this review aims to provide a summary of the association between dietary carotenoid intake and the risk of CVDs from published epidemiological studies. Meanwhile, to further elucidate the roles of carotenoid intake in CVD protection, this review outlines the evidence reporting the effects of carotenoids on cardiovascular health from randomized controlled trials by assessing classical CVD risk factors, oxidative stress, inflammatory markers and vascular health-related parameters, respectively. Given the considerable discrepancies among the published results, this review underlines the importance of bioavailability and summarizes the current dietary strategies for improving the bioavailability of carotenoids. In conclusion, this review supports the protective roles of carotenoids against CVDs, possibly by attenuating oxidative stress and mitigating inflammatory response. In addition, this review suggests that the bioavailability of carotenoids should be considered when evaluating the roles of carotenoids in CVD protection.

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Section: Randomized Controlled Trials On Carotenoids and Cvdsmentioning

confidence: 99%

The Roles of Carotenoid Consumption and Bioavailability in Cardiovascular Health

2021

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“…In this study, we demonstrate the capabilities of PD-US for detecting perfusion changes associated with diabetes including the assessment of endothelial function. The independence of endothelial responses in conduit and resistance vessels suggests there is scale-dependent information about the risk of atherogenesis advancing toward coronary artery disease [ 7 ], [ 8 ]. Changes in the function of conduit vessel endothelium measures the risks associated with advancing age and hypertension.…”

Section: Introductionmentioning

confidence: 99%

Power-Doppler Ultrasonic Imaging of Peripheral Perfusion in Diabetic Mice

Babaei,

Dobrucki,

Insana

2024

IEEE Trans. Biomed. Eng.

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Objective: We explored the capabilities of power-Doppler ultrasonic (PD-US) imaging without contrast enhancement for monitoring changes in muscle perfusion over time. Methods: Ischemic recovery was observed in healthy and type II diabetic male and female mice with and without exercise. In separate studies, perfusion was measured during and after 5-min ischemic periods and during four-week recovery periods following irreversible femoral ligation. A goal was to assess how well PD-US estimates tracked the diabetic-related changes in endothelial function that influenced perfusion. Results: The average perfusion recovery time following femoral ligation increased 47% in diabetic males and 74% in diabetic females compared with non-diabetic mice. Flow-mediated dilation in conduit arteries and the reactive hyperemia index in resistive vessels each declined by one half in sedentary diabetic mice compared with sedentary non-diabetic mice. We found that exercise reduced the loss of endothelial function from diabetes in both sexes. The reproducibility of perfusion measurements was limited primarily by our ability to select the same region in muscle and to effectively filter tissue clutter. Conclusions/Significance: PD-US measurements can precisely follow site-specific changes in skeletal muscle perfusion related to diabetes over time, which fills the need for techniques capable of regularly monitoring atherosclerotic changes leading to ischemic vascular pathologies.

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Transcatheter aortic valve implantation and its impact on endothelial function in patients with aortic stenosis

Arnold,

Haas,

Jakob

et al. 2025

Microvascular Research

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Which is the best method in clinical practice for assessing improvement in vascular endothelial function after successful smoking cessation — Flow-mediated dilation (FMD) or reactive hyperemic peripheral arterial tonometry (RH-PAT)?

Cited by 4 publications

References 7 publications

The Roles of Carotenoid Consumption and Bioavailability in Cardiovascular Health

The Roles of Carotenoid Consumption and Bioavailability in Cardiovascular Health

Power-Doppler Ultrasonic Imaging of Peripheral Perfusion in Diabetic Mice

Transcatheter aortic valve implantation and its impact on endothelial function in patients with aortic stenosis

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