Which Method of GFR Estimation Has the Best Prognostic Value in Patients Treated with Primary PCI: Cockcroft–Gault Formula, MDRD, or CKD-EPI Equation?—A 6-Year Follow-Up

Tomaszuk‐Kazberuk, Anna; Kożuch, Marcin; Małyszko, Jolanta; Bachórzewska−Gajewska, Hanna; Dobrzycki, Sławomir; Musiał, Włodzimierz J.

doi:10.3109/0886022x.2011.618922

Cited by 24 publications

(23 citation statements)

References 34 publications

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“…Nevertheless, the MCQE equation more accurately classified individuals compared with MDRD and CG formulae. Our results extend knowledge from previous studies [1],[2]. Further investigations should be performed to determine whether these costless formulae could be used as an additional validated predictor in this group of patients and hence whether they could be incorporated into clinical practice.…”

Section: Resultssupporting

confidence: 84%

Impact of kidney function calculation formulae on predicting early adverse renal events in cardiac surgery

et al. 2014

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Section: Resultssupporting

confidence: 84%

Impact of kidney function calculation formulae on predicting early adverse renal events in cardiac surgery

et al. 2014

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“…23 A previous prospective cohort study of patients with STEMI followed up during a long time also demonstrated that the Cockcroft-Gault formula was superior than MDRD and CKD-EPI equations at predicting mortality after acute myocardial infarction. 24 Similar results were found in a study including patients with ACS, in which Cockcroft-Gault equation better stratified patients according to their risk of 1-year mortality in comparison to the MDRD-4 or the CKD-EPI equations. 25 In a nationwide registry in Sweden, Cockcroft-Gault equation was better than the MDRD equation in predicting mortality after a myocardial infarction, and seems to be superior for predicting short-and long-term mortality.…”

Section: Discussionsupporting

confidence: 83%

“…Thus, in a recent report from a large registry including patients with heart failure, the Cockcroft‐Gault equation predicted mortality better than the CKD‐EPI and MDRD equations . A previous prospective cohort study of patients with STEMI followed up during a long time also demonstrated that the Cockcroft‐Gault formula was superior than MDRD and CKD‐EPI equations at predicting mortality after acute myocardial infarction . Similar results were found in a study including patients with ACS, in which Cockcroft‐Gault equation better stratified patients according to their risk of 1‐year mortality in comparison to the MDRD‐4 or the CKD‐EPI equations .…”

Section: Discussionsupporting

confidence: 57%

Disparities in the Estimation of Glomerular Filtration Rate According to Cockcroft‐Gault, Modification of Diet in Renal Disease‐4, and Chronic Kidney Disease Epidemiology Collaboration Equations and Relation With Outcomes in Patients With Acute Coronary Syndrome

Rivera‐Caravaca

Ruiz-Nodar

Tello‐Montoliu

et al. 2018

JAHA

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BackgroundA simple method to assess renal function is the estimated glomerular filtration rate, and it shows prognostic implications. However, it remains unknown which equation should be used in patients with acute coronary syndrome. We compared the ability and correlation of the Cockcroft‐Gault, Modification of Diet in Renal Disease‐4 (MDRD‐4), and Chronic Kidney Disease Epidemiology Collaboration (CKD‐EPI) equations and their predictive performance for major adverse cardiovascular events, all‐cause mortality, and major bleeding in a cohort of patients with acute coronary syndrome.Methods and ResultsMulticenter prospective registry involving 1699 consecutive patients with acute coronary syndrome from 3 tertiary institutions. At entry, renal function was assessed using the Cockcroft‐Gault, MDRD‐4, and CKD‐EPI‐creatinine equations. During 12 months of follow‐up, we recorded all major adverse cardiovascular events (composite of cardiovascular death, nonfatal myocardial infarction, and nonfatal ischemic stroke), bleeding events (Bleeding Academic Research Consortium classification), and all‐cause mortality. Receiver operating characteristic curve comparisons demonstrated that Cockcroft‐Gault equation had higher predictive ability compared with MDRD‐4 equation for major adverse cardiovascular events (0.651 versus 0.616; P=0.023), major bleeding (0.600 versus 0.551; P=0.005), and all‐cause mortality (0.754 versus 0.717; P=0.033), as well as higher predictive ability compared with CKD‐EPI equation for major bleeding (0.600 versus 0.564; P=0.018). Integrated discrimination improvement and net reclassification improvement analyses showed superior discrimination and reclassification of Cockcroft‐Gault equation. Decision curve analyses graphically demonstrated higher net benefit and clinical usefulness of the Cockcroft‐Gault equation in comparison with MDRD‐4 and CKD‐EPI equations.ConclusionsIn patients with acute coronary syndrome, the Cockcroft‐Gault equation presented superior predictive ability for major adverse cardiovascular events, major bleeding, and all‐cause mortality compared with MDRD‐4 equation, and superior predictive ability for major bleeding compared with CKD‐EPI equation. The Cockcroft‐Gault equation also showed higher net benefit and clinical usefulness.

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“…The prognostic importance of CKD‐EPI has been evaluated in different settings. In one study in patients with myocardial infarction, CKD‐EPI was inferior to the Cockcroft–Gault equation in predicting mortality, but was a powerful predictor of in‐hospital events in a study of patients with acute coronary syndrome . In a large population of acute myocardial infarction patients with impaired systolic function or signs of heart failure, use of the CKD‐EPI equation improved risk stratification compared with sMDRD .…”

Section: Discussionmentioning

confidence: 99%

The Chronic Kidney Disease Epidemiology Collaboration equation outperforms the Modification of Diet in Renal Disease equation for estimating glomerular filtration rate in chronic systolic heart failure

Valente

Hillege

Navis

et al. 2013

European J of Heart Fail

111

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AimsThe Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula estimates glomerular filtration rate (GFR) better than the simplified Modification of Diet in Renal Disease (sMDRD) formula in numerous populations. It has not previously been validated in heart failure patients. Methods and resultsThe GFR was measured in 120 patients with chronic systolic heart failure (CHF) using [125 I]iothalamate clearance (GFR IOTH ) and estimated using the sMDRD and CKD-EPI equations. Accuracy, bias, and prognostic performance were compared. Cockcroft-Gault, CKD-EPI serum cystatin C, and CKD-EPI creatinine-serum cystatin C equations were compared in secondary analyses. Mean age was 59 + 12 years, 80% were male. Mean LVEF was 29 + 10%. Mean GFR IOTH was 74 + 27 mL/min/1.73 m 2 , and mean estimated GFR was 66 + 23 mL/min/1.73 m 2 (CKD-EPI) and 63 + 21 mL/min/1.73m 2 (sMDRD). CKD-EPI showed less bias than sMDRD (-8 + 15 vs. -11 + 16 mL/min/1.73 m 2 , P , 0.001). Both equations underestimate at higher and overestimate at lower GFR IOTH . Eleven patients (9%) were accurately reclassified into lower CKD classes with CKD-EPI. Cockcroft -Gault showed lower bias ( -3 + 16 mL/min/ 1.73 m 2 ) but worse precision and accuracy. Cystatin C-based estimation showed the lowest bias ( -3 + 14 mL/min/ 1.73 m 2 ) and the best precision and accuracy. Prognostic value did not differ between all GFR estimates ConclusionThe CKD-EPI equation more accurately estimates measured GFR than the sMDRD equation in CHF patients, with less bias and greater accuracy and precision. The prognostic power of all GFR assessments was equivalent. Based on better performance and equal risk prediction, we believe the CKI-EPI equation should be the preferred creatinine-based GFR estimation method in heart failure patients, particularly those with preserved or moderately impaired renal function.--

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Which Method of GFR Estimation Has the Best Prognostic Value in Patients Treated with Primary PCI: Cockcroft–Gault Formula, MDRD, or CKD-EPI Equation?—A 6-Year Follow-Up

Abstract: CKD is associated with higher mortality after a successful primary PCI during a 6-year follow-up. C-G formula is better than MDRD and CKD-EPI equations at predicting mortality after AMI.

Cited by 24 publications

References 34 publications

Impact of kidney function calculation formulae on predicting early adverse renal events in cardiac surgery

Impact of kidney function calculation formulae on predicting early adverse renal events in cardiac surgery

Disparities in the Estimation of Glomerular Filtration Rate According to Cockcroft‐Gault, Modification of Diet in Renal Disease‐4, and Chronic Kidney Disease Epidemiology Collaboration Equations and Relation With Outcomes in Patients With Acute Coronary Syndrome

The Chronic Kidney Disease Epidemiology Collaboration equation outperforms the Modification of Diet in Renal Disease equation for estimating glomerular filtration rate in chronic systolic heart failure

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