Which Strategies can be Adopted against Heavy Metal Intoxication?

Fulgenzi, Alessandro; Ferrero, Maria Elena

doi:10.21767/2473-6457.100014

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Of note, all our patients eliminated smoking. However, in patients affected by chronic metal intoxications who have developed ND and/or CVD, the use of chelation therapy with EDTA represents an excellent option to ameliorate symptoms [84]. The relation between metal intoxication and ND is highlighted by previous studies and newly reported cases in this paper.…”

Section: Discussionmentioning

confidence: 70%

EDTA Chelation Therapy for the Treatment of Neurotoxicity

Fulgenzi

Ferrero

2019

IJMS

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Neurotoxicity can be caused by numerous direct agents, of which toxic metals, organophosphorus pesticides, air pollution, radiation and electromagnetic fields, neurotoxins, chemotherapeutic and anesthetic drugs, and pathogens are the most important. Other indirect causes of neurotoxicity are cytokine and/or reactive oxygen species production and adoptive immunotherapy. The development of neurodegenerative diseases has been associated with neurotoxicity. Which arms are useful to prevent or eliminate neurotoxicity? The chelating agent calcium disodium ethylenediaminetetraacetic acid (EDTA)—previously used to treat cardiovascular diseases—is known to be useful for the treatment of neurodegenerative diseases. This review describes how EDTA functions as a therapeutic agent for these diseases. Some case studies are reported to confirm our findings.

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Section: Discussionmentioning

confidence: 70%

EDTA Chelation Therapy for the Treatment of Neurotoxicity

Fulgenzi

Ferrero

2019

IJMS

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Ağır Metal Toksisitesinin İnsan Sağlığına Etkileri

Özbolat

Tuli

2016

Arşiv Kaynak Tarama Dergisi

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Heavy metals are the elements that can be toxic even at low concentrations. It is often used as a group name for metals and semimetals (metalloids) that have been associated with contamination and potential toxicity or ecotoxicity. Heavy metals are toxic to human health. Because it cannot be discarded with (kidney, liver intestine, skin, lung) without special support from most of the body's normal excretion routes Therefore, a large part of the heavy metals accumulate in biological organisms. As a result of the accumulation of these metals that are focused within living things, when they have reached the effective dose severe diseases (such as autism neurological, thyroid and infertility) even can cause death. In this review information about the properties and effects of some heavy metals that affects human health have been provided. Key words: Heavy metals, disease, toxic effect. ÖZAğır metaller; düşük derişimlerde bile toksik etki gösterebilen elementlerdir. Genellikle kontaminasyon ve potansiyel toksisite ya da eko-toksisite ile ilişkilendirilen metaller ya da yarı metaller (metalloidler) olarak isimlendirilirler. Ağır metaller organizmaya ağız, solunum ve deri yolu ile alınır ve çoğu özel bir destek olmadan vücudun boşaltım yolları ile (böbrek, karaciğer, barsak, akciğer, deri) atılamazlar. Bu nedenle ağır metallerin büyük bir bölümü, biyolojik organizmalarda birikirler. Birikim sonucu, canlıların bünyesinde yoğunlaşan bu metaller, etkili dozlara ulaştıklarında, ciddi hastalıklara (tiroit, nörolojik, otizm ve kısırlık gibi) hatta ölümlere neden olabilirler. Bu derlemede, insan sağlığını etkileyen bazı ağır metalleri ve bu metallerin özellikleri hakkında bilgi verilmektedir. Anahtar kelimeler: Ağır metaller, hastalık, toksik etki.

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Which Strategies can be Adopted against Heavy Metal Intoxication?

Cited by 2 publications

References 11 publications

EDTA Chelation Therapy for the Treatment of Neurotoxicity

EDTA Chelation Therapy for the Treatment of Neurotoxicity

Ağır Metal Toksisitesinin İnsan Sağlığına Etkileri

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