White graphene quantum dots as electrochemical sensing platform for ferritin

Garg, Mayank; Rani, Reetu; Sharma, Amit L.; Singh, Suman

doi:10.1039/c9fd00111e

Cited by 28 publications

(10 citation statements)

References 26 publications

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“…Therefore, the utilization of QDs in a biosensing platform can increase the linear operating range of a sensor. A similar advantage was observed in the work reported by Garg et al [ 81 ]. Tanak et al [ 98 ] used impedimetric sensor-based zinc oxide-modified gold-interdigitated electrodes for PCT detection for sepsis diagnosis.…”

Section: Infection-mediated Clinical Biomarkers and Their Electrical Biosensorssupporting

confidence: 89%

“…The sensor exhibited a linear range of 10–1500 ng/mL and an LOD of 6.048 and 3.800 ng/mL for cyclic voltammetry and direct pulse voltammetry, respectively. Garg et al [ 81 ] used transition metal chalcogenides (TMDs), which were hexagonal boron nitride (HBN) QDs, for sensing serum ferritin. The use of HBN QDs, also known as white graphene, improved the linear range and LOD for serum ferritin detection.…”

Section: Infection-mediated Clinical Biomarkers and Their Electrical Biosensorsmentioning

confidence: 99%

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Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Selvarajan

Gopinath

Zin

et al. 2021

Sensors

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The race towards the development of user-friendly, portable, fast-detection, and low-cost devices for healthcare systems has become the focus of effective screening efforts since the pandemic attack in December 2019, which is known as the coronavirus disease 2019 (COVID-19) pandemic. Currently existing techniques such as RT-PCR, antigen–antibody-based detection, and CT scans are prompt solutions for diagnosing infected patients. However, the limitations of currently available indicators have enticed researchers to search for adjunct or additional solutions for COVID-19 diagnosis. Meanwhile, identifying biomarkers or indicators is necessary for understanding the severity of the disease and aids in developing efficient drugs and vaccines. Therefore, clinical studies on infected patients revealed that infection-mediated clinical biomarkers, especially pro-inflammatory cytokines and acute phase proteins, are highly associated with COVID-19. These biomarkers are undermined or overlooked in the context of diagnosis and prognosis evaluation of infected patients. Hence, this review discusses the potential implementation of these biomarkers for COVID-19 electrical biosensing platforms. The secretion range for each biomarker is reviewed based on clinical studies. Currently available electrical biosensors comprising electrochemical and electronic biosensors associated with these biomarkers are discussed, and insights into the use of infection-mediated clinical biomarkers as prognostic and adjunct diagnostic indicators in developing an electrical-based COVID-19 biosensor are provided.

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Section: Infection-mediated Clinical Biomarkers and Their Electrical Biosensorssupporting

confidence: 89%

Section: Infection-mediated Clinical Biomarkers and Their Electrical Biosensorsmentioning

confidence: 99%

Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Selvarajan

Gopinath

Zin

et al. 2021

Sensors

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“…In an effort, to further improve both the linear range and LOD, white graphene QDs (hexagonal boron nitride QDs), were deployed for sensor functionalization and system was able to provide much wider linear range than our previous work. The linear range in this case was 10–2000 ng/mL and LOD value was calculated to be 1.306 ng/mL ( Singh et al, 2020 ). More recently, a graphene modified paper based electrochemical sensor for ferritin was also reported ( Boonkaew et al, 2020 ), in which the antibodies were attached to the electrode surface using the EDC/NHS chemistry.…”

Section: Inflammatory Biomarkers and Their Detection Platformsmentioning

confidence: 91%

Advancement in biosensors for inflammatory biomarkers of SARS-CoV-2 during 2019–2020

Garg

Sharma

Singh

2021

Biosensors and Bioelectronics

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COVID-19 pandemic has affected everyone throughout the world and has resulted in the loss of lives of many souls. Due to the restless efforts of the researchers working hard day and night, some success has been gained for the detection of virus. As on date, the traditional polymerized chain reactions (PCR), lateral flow devices (LFID) and enzyme linked immunosorbent assays (ELISA) are being adapted for the detection of this deadly virus. However, a more exciting avenue is the detection of certain biomarkers associated with this viral infection which can be done by simply re-purposing our existing infrastructure. SARS-CoV-2 viral infection triggers various inflammatory, biochemical and hematological biomarkers. Because of the infection route that the virus follows, it causes significant inflammatory response. As a result, various inflammatory markers have been reported to be closely associated with this infection such as C-reactive proteins, interleukin-6, procalcitonin and ferritin. Sensing of these biomarkers can simultaneously help in understanding the illness level of the affected patient. Also, by monitoring these biomarkers, we can predict the viral infections in those patients who have low SARS-CoV-2 RNA and hence are missed by traditional tests. This can give more targets to the researchers and scientists, working in the area of drug development and provide better prognosis. In this review, we propose to highlight the conventional as well as the non-conventional methods for the detection of these inflammatory biomarkers which can act as a single platform of knowledge for the researchers and scientists working for the treatment of COVID-19.

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“…Electrochemical impedance spectroscopy is used in a platform where hBN QDs are a functionalized detection platform for screen-printed electrodes. The developed immune sensor has a linear range from 10 to 2000 ng/ml -1 ferritin concentration with a detection limit of 1.306 ng/ml -1 ( 56 ).…”

Section: Nanoparticle-based Detection Strategies Of Covid-19mentioning

confidence: 99%

State-of-the-art colloidal particles and unique interfaces-based SARS-CoV-2 detection methods and COVID-19 diagnosis

Saatçi

Natarajan

2021

Current Opinion in Colloid & Interface Science

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In March 2020, SARS-CoV-2 based infections were declared ‘COVID-19 pandemic’ by the World Health Organization (WHO). Pandemic raised the necessity to design and develop genuine and sensitive tests for precise specific SARS-CoV-2 infections detection. Nanotechnological methods offer new ways to fight COVID-19. Nanomaterials are ideal for unique sensor platforms due to their easy manufacturing, chemically versatile properties. In this context, selected examples for integrating nanomaterials and distinct biosensor platforms are given to detect SARS-CoV-2 biological materials and COVID-19 biomarkers, giving researchers and scientists more goals and a better forecast to design more relevant and novel sensor arrays for COVID-19 diagnosis.

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White graphene quantum dots as electrochemical sensing platform for ferritin

Abstract: The use of hexagonal boron nitride quantum dots (hBN QDs) as an electrochemical sensor for ferritin is reported for the first time in this manuscript. These QDs were synthesized using...

Cited by 28 publications

References 26 publications

Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Infection-Mediated Clinical Biomarkers for a COVID-19 Electrical Biosensing Platform

Advancement in biosensors for inflammatory biomarkers of SARS-CoV-2 during 2019–2020

State-of-the-art colloidal particles and unique interfaces-based SARS-CoV-2 detection methods and COVID-19 diagnosis

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