White Matter Aberrations in Prepubertal Estrogen-Naive Girls with Monosomic Turner Syndrome

Yamagata, Bun; Barnea-Goraly, Naama; Marzelli, Matthew; Park, Yae-Na; Hong, David S.; Mimura, Masaru; Reiss, Allan L.

doi:10.1093/cercor/bhr355

Cited by 30 publications

(22 citation statements)

References 50 publications

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“…Holzapfel (2006) found lower FA in the bilateral internal capsule as well as in the left parieto‐occipital region, extending along the superior longitudinal fasciculus. Yamagata et al (2012) found widespread reductions in FA in girls with TS in a number of tracts connecting regions implicated in the cognitive deficits characteristic of TS. Turner syndrome (TS) is marked by widespread deficits in white matter pathways, especially in anterior–posterior tracts, so it is not surprising that functional connectivity is altered as well.…”

Section: Structural and Functional Connectivity In Atypical Brain Devmentioning

confidence: 87%

Reprint of: Mapping connectivity in the developing brain

Dennis¹,

Thompson²

2013

Intl J of Devlp Neuroscience

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Recently, there has been a wealth of research into structural and functional brain connectivity, and how they change over development. While we are far from a complete understanding, these studies have yielded important insights into human brain development. There is an ever growing variety of methods for assessing connectivity, each with its own advantages. Here we review research on the development of structural and/or functional brain connectivity in both typically developing subjects and subjects with neurodevelopmental disorders. Space limitations preclude an exhaustive review of brain connectivity across all developmental disorders, so we review a representative selection of recent findings on brain connectivity in autism, Fragile X, 22q11.2 deletion syndrome, Williams syndrome, Turner syndrome, and ADHD. Major strides have been made in understanding the developmental trajectory of the human connectome, offering insight into characteristic features of brain development and biological processes involved in developmental brain disorders. We also discuss some common themes, including hemispheric specialization -or asymmetry -and sex differences. We conclude by discussing some promising future directions in connectomics, including the merger of imaging and genetics, and a deeper investigation of the relationships between structural and functional connectivity.

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Section: Structural and Functional Connectivity In Atypical Brain Devmentioning

confidence: 87%

Reprint of: Mapping connectivity in the developing brain

Dennis¹,

Thompson²

2013

Intl J of Devlp Neuroscience

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show abstract

“…The structure of the parietal lobe [16–18] and its connectivity with other cortical regions (notably the frontal cortex) [19, 20] appear to differ between individuals with TS and controls. In addition, task-based [21–23] and resting-state [24] functional connectivity measures between the frontal and parietal cortex are reduced in girls with TS.…”

Section: Brain Phenotype In Ts Nf1 and Ns: Clinical And Animal Modelmentioning

confidence: 99%

Attention deficit hyperactivity disorder (ADHD) in phenotypically similar neurogenetic conditions: Turner syndrome and the RASopathies

Green

Naylor

Davies

2017

J Neurodevelop Disord

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BackgroundADHD (attention deficit hyperactivity disorder) is a common neurodevelopmental disorder. There has been extensive clinical and basic research in the field of ADHD over the past 20 years, but the mechanisms underlying ADHD risk are multifactorial, complex and heterogeneous and, as yet, are poorly defined. In this review, we argue that one approach to address this challenge is to study well-defined disorders to provide insights into potential biological pathways that may be involved in idiopathic ADHD.Main bodyTo address this premise, we selected two neurogenetic conditions that are associated with significantly increased ADHD risk: Turner syndrome and the RASopathies (of which Noonan syndrome and neurofibromatosis type 1 are the best-defined with regard to ADHD-related phenotypes). These syndromes were chosen for two main reasons: first, because intellectual functioning is relatively preserved, and second, because they are strikingly phenotypically similar but are etiologically distinct. We review the cognitive, behavioural, neural and cellular phenotypes associated with these conditions and examine their relevance as a model for idiopathic ADHD.ConclusionWe conclude by discussing current and future opportunities in the clinical and basic research of these conditions, which, in turn, may shed light upon the biological pathways underlying idiopathic ADHD.

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Section: Structural and Functional Connectivity In Atypical Brain Devmentioning

confidence: 99%

Mapping connectivity in the developing brain

Dennis¹,

Thompson²

2013

Intl J of Devlp Neuroscience

View full text Add to dashboard Cite

Recently, there has been a wealth of research into structural and functional brain connectivity, and how they change over development. While we are far from a complete understanding, these studies have yielded important insights into human brain development. There is an ever growing variety of methods for assessing connectivity, each with its own advantages. Here we review research on the development of structural and/or functional brain connectivity in both typically developing subjects and subjects with neurodevelopmental disorders. Space limitations preclude an exhaustive review of brain connectivity across all developmental disorders, so we review a representative selection of recent findings on brain connectivity in autism, Fragile X, 22q11.2 deletion syndrome, Williams syndrome, Turner syndrome, and ADHD. Major strides have been made in understanding the developmental trajectory of the human connectome, offering insight into characteristic features of brain development and biological processes involved in developmental brain disorders. We also discuss some common themes, including hemispheric specialization – or asymmetry – and sex differences. We conclude by discussing some promising future directions in connectomics, including the merger of imaging and genetics, and a deeper investigation of the relationships between structural and functional connectivity.

show abstract

White Matter Aberrations in Prepubertal Estrogen-Naive Girls with Monosomic Turner Syndrome

Cited by 30 publications

References 50 publications

Reprint of: Mapping connectivity in the developing brain

Reprint of: Mapping connectivity in the developing brain

Attention deficit hyperactivity disorder (ADHD) in phenotypically similar neurogenetic conditions: Turner syndrome and the RASopathies

Mapping connectivity in the developing brain

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