White matter hyperintensities and headache: A population-based imaging study (HUNT MRI)

Honningsvåg, Lasse-Marius; Håberg, Asta; Hagen, Knut; Kvistad, Kjell Arne; Stovner, Lars Jacob; Linde, Mattias

doi:10.1177/0333102418764891

Cited by 33 publications

(49 citation statements)

References 32 publications

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“…In a large population-based cohort of 70-year old individuals, 15.1% had a high Fazekas WMSA burden. This frequency is, as expected, higher than that reported in younger population-based cohorts (frequency of 10%) [16] and lower than that reported in older cohorts (frequencies between 26-36%) [3,17]. Our correlation analyses showed a strong association between LST and FreeSurfer WMSA.…”

Section: Discussionsupporting

confidence: 80%

“…However, given the quadratic association between both automated measures and previous findings showing similar results [2,14,15], we suggest that our findings are related to different underlying pathology rather than the differences in their slice thickness. The association of Fazekas scores, LST WMSA, and FreeSurfer WMSA with demographic, cognitive, and clinical factors has been investigated in previous studies [4,5,16,17,23,24] and is beyond the scope of our study. We decided to focus on the association between these three methods and their potential interchangeability, as well as on deriving cut-off values for predicting high and low Fazekas scores from automatic segmentations of WMSA.…”

Section: Discussionmentioning

confidence: 99%

“…WMSA in large confluent areas). The frequently used Fazekas clinical classification in low and high WMSA burden [16,24,26] was applied to address the secondary aim of this study. High WMSA burden was defined as Fazekas scores 2 or 3.…”

Section: Mri Data Acquisition Image Processing and Measurements Of mentioning

confidence: 99%

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Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities

Cedrés

Ferreira

Machado

et al. 2020

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities

Cedrés

Ferreira

Machado

et al. 2020

Aging

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“…Two large scale European epidemiological studies, one in France and one in Iceland, have both demonstrated an association with headache and WMC volumes, the former with ‘severe headache’ and the latter, most strikingly, with tension‐type headache. (Kruit et al , ; Kurth et al , ; Gaist et al , ; Honningsvåg et al , ).…”

Section: Discussionmentioning

confidence: 99%

Headache: an important symptom possibly linked to white matter lesions in thalassaemia

et al. 2019

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Neurological manifestations are reported only occasionally in patients with thalassaemia and are given much less prominence than the complications related to anaemia and iron overload. White matter changes (WMCs) on magnetic resonance imaging (MRI) in patients with thalassaemia were first reported two decades ago but the significance of these lesions remains unclear. We studied the neurological and cognitive manifestations in 82 older patients with thalssaemia [25 Thalassaemia major (TM), 24 thalassaemia intermedia (TI) and 33 haemaglobin E b thalassaemia (EBT)] and 80 controls, and found that headaches were more common in thalassaemia patients (50/82, 61%) than in controls (18/80, 22Á5%: P < 0Á001). WMCs on MRI were found in 20/82 (24Á3%) patients and 2/29 (6Á9%) controls had (P = 0Á078). WMC were more common among those with headaches (17/50: 34%) than in those without headache (3/32; 9Á3%) (P = 0Á023). WMCs were not associated with reduction of cognition. Nevertheless, cognition was lower in the TI and EBT groups compared with those with TM (P = 0Á002). The association of headache with WMC in thalassaemia has not been reported before and warrants further study.

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“…Recently years, whether the white matter of migraineurs destroyed was still in dispute. Two population-based imaging studies [22,23] indicated the damages on white matter for migraineurs compared with the healthy controls. Two trials [24,25] also showed the microstructural alterations of the white matter in migraineurs.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture affects different ways for migraineurs of long- and short- courses on the efficiency of structural brain network

et al. 2020

Preprint

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Background: To study the impact of acupuncture treatment on structural brain network for patients with different courses of migraine without aura based on fMRI. Methods: A total of ten patients with a long course (>5 years) of migraine without aura (MWoA), ten patients with a short course (<5 years) of MWoA, and ten healthy volunteers were recruited in this trail. All patients received acupuncture treatment three times per week for four weeks. The changes in the topology properties of structural brain regions were observed via fMRI. The clinical symptom scores were adopted for evaluating the therapeutic effect. Results: 1) The small-world property on the group with a long course was decreased significantly (p<0.01) after treatment, while the group with a short course increased (p<0.01). 2) The clustering coefficient or nodal local efficiency of brain nodes (including the pontine crossing tract, left corticospinal tract, right medial lemniscus, left posterior limb of the internal capsule, right cingulum hippocampus, left fornix, left superior longitudinal fasciculus and right tapetum) showed significant changes (p<0.001) with an opposite tendency on the two groups after treatment. 3) The left posterior limb of the internal capsule (p<0.001, R=-0.73) and right tapetum (p<0.05, R=-0.54) had a strong relationship with migraine courses. Conclusions: The two unequal ways of acupuncture on the structural brain network of migraineurs with different disease courses were revealed. Acupuncture could regulate the central sensitization of chronic migraines, differently with the early stage. The nodal efficiency of the left posterior limb of the internal capsule and right tapetum would be symbols to discriminate against the process of MWoA.

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White matter hyperintensities and headache: A population-based imaging study (HUNT MRI)

Cited by 33 publications

References 32 publications

Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities

Predicting Fazekas scores from automatic segmentations of white matter signal abnormalities

Headache: an important symptom possibly linked to white matter lesions in thalassaemia

Acupuncture affects different ways for migraineurs of long- and short- courses on the efficiency of structural brain network

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