2024
DOI: 10.1096/fj.202400689rr
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White matter hyperintensity genetic risk factor TRIM47 regulates autophagy in brain endothelial cells

Sunny Hoi‐Sang Yeung,
Ralph Hon‐Sun Lee,
Gerald Wai‐Yeung Cheng
et al.

Abstract: White matter hyperintensity (WMH) is strongly correlated with age‐related dementia and hypertension, but its pathogenesis remains obscure. Genome‐wide association studies identified TRIM47 at the 17q25 locus as a top genetic risk factor for WMH formation. TRIM family is a class of E3 ubiquitin ligase with pivotal functions in autophagy, which is critical for brain endothelial cell (ECs) remodeling during hypertension. We hypothesize that TRIM47 regulates autophagy and its loss‐of‐function disturbs cerebrovascu… Show more

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