White Matter Integrity Determined With Diffusion Tensor Imaging in Older Adults Without Dementia

Kantarci, Kejal; Schwarz, Christopher G.; Reid, Robert I.; Przybelski, Scott A.; Lesnick, Timothy G.; Zuk, Samantha M.; Senjem, Matthew L.; Gunter, Jeffrey L.; Lowe, Val J.; Machulda, Mary M.; Knopman, David S.; Petersen, Ronald C.; Jack, Clifford R.

doi:10.1001/jamaneurol.2014.1482

Cited by 65 publications

(56 citation statements)

References 44 publications

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“…Still, our results may provide a few clues to start deciphering these pathways. First, the strong relation of the MeDi with WM microstructure in extensive areas (with no specific involvement of tracts generally altered in AD, e.g., the cingulum and fornix) along with the absence of meaningful association with GM atrophy (specifically in AD regions, e.g., the hippocampus) suggests that mechanisms are not primarily related to AD neurodegeneration [35][36][37][38][39][40]. It remains possible that our study was underpowered to detect associations with volumes; however, we were able to detect the effect of age, suggesting sufficient power in this sample to capture wellestablished risk factors for brain atrophy.…”

Section: Discussionmentioning

confidence: 99%

Mediterranean diet and preserved brain structural connectivity in older subjects

Pelletier

Barul

Féart

et al. 2015

Alzheimer's & Dementia

118

119

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Section: Discussionmentioning

confidence: 99%

Mediterranean diet and preserved brain structural connectivity in older subjects

Pelletier

Barul

Féart

et al. 2015

Alzheimer's & Dementia

118

119

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show abstract

“…Other recent studies examined white matter changes in asymptomatic individuals showing biomarker evidence of amyloid or tau pathology (Bendlin et al, 2012;Chao et al, 2013;Gold et al, 2014;Kantarci et al, 2014;Molinuevo et al, 2014;Racine et al, 2014;Stenset et al, 2011). These cross-sectional studies of at-risk populations are now increasingly being complemented by longitudinal follow-up studies that allow relating the detected imaging abnormalities to future clinical outcomes Fletcher et al, 2013;Mielke et al, 2012;Zhuang et al, 2012).…”

Section: Structural Disconnection In the Course Of Admentioning

confidence: 99%

“…( Kantarci et al, 2014) DTI, Amyloid-PET, FDG-PET Fiber tract integrity was assessed in 570 cognitively normal subjects and 131 MCI individuals stratified by amyloid load and neurodegeneration status. FA of the fornix body decreased with neurodegeneration and was significantly associated with cognitive performance.…”

Section: Dti + (Amyloid-pet/fdg-pet)mentioning

confidence: 99%

Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications

Teipel

Grothe

Zhou

et al. 2016

J Int Neuropsychol Soc

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Objectives: The objective was to review the literature on diffusion tensor imaging as well as resting-state functional magnetic resonance imaging and electroencephalography (EEG) to unveil neuroanatomical and neurophysiological substrates of Alzheimer's disease (AD) as a brain neural network pathology affecting structural and functional cortical connectivity underlying human cognition. Methods: We reviewed papers registered in PubMed and other scientific repositories on the use of these techniques in amnesic mild cognitive impairment (MCI) and clinically mild AD dementia patients compared to cognitively intact elderly individuals (Controls). Results: Hundreds of peer-reviewed (cross-sectional and longitudinal) papers have shown in patients with MCI and mild AD compared to Controls (1) impairment of callosal (splenium), thalamic, and anterior-posterior white matter bundles; (2) reduced correlation of resting state blood oxygen level-dependent activity across several intrinsic brain circuits including default mode and attention-related networks; and (3) abnormal power and functional coupling of resting state cortical EEG rhythms. Clinical applications of these measures are still limited. Conclusions: Structural and functional (in vivo) cortical connectivity measures represent a reliable marker of cerebral reserve capacity and should be used to predict and monitor the evolution of AD and its relative impact on cognitive domains in pre-clinical, prodromal, and dementia stages of AD. (JINS, 2016, 22, 138-163)

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“…51) In addition, unlike the other WM tracts, FA values from the fornix were not influenced by the noise of crossing fibers. 52) Hence, the inclusion of the fornix tract in the next version of TRACULA software would be increase validity of this program as AD biomarker analysis tool.…”

Section: Discussionmentioning

confidence: 99%

[P3–369]: Diagnostic Validity of an Automated Probabilistic Tractography in Amnestic Mild Cognitive Impairment

Lee

Kang

Lim

2017

Alzheimer's & Dementia

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Objective: Although several prior works showed the white matter (WM) integrity changes in amnestic mild cognitive impairment (aMCI) and Alzheimer's disease, it is still unclear the diagnostic accuracy of the WM integrity measurements using diffusion tensor imaging (DTI) in discriminating aMCI from normal controls. The aim of this study is to explore diagnostic validity of whole brain automated probabilistic tractography in discriminating aMCI from normal controls. Methods: One hundred-two subjects (50 aMCI and 52 normal controls) were included and underwent DTI scans. Whole brain WM tracts were reconstructed with automated probabilistic tractography. Fractional anisotropy (FA) and mean diffusivity (MD) values of the memory related WM tracts were measured and compared between the aMCI and the normal control groups. In addition, the diagnostic validities of these WM tracts were evaluated. Results: Decreased FA and increased MD values of memory related WM tracts were observed in the aMCI group compared with the control group. Among FA and MD value of each tract, the FA value of left cingulum angular bundle showed the highest area under the curve (AUC) of 0.85 with a sensitivity of 88.2%, a specificity of 76.9% in differentiating MCI patients from control subjects. Furthermore, the combination FA values of WM integrity measures of memory related WM tracts showed AUC value of 0.98, a sensitivity of 96%, a specificity of 94.2%. Conclusion: Our results with good diagnostic validity of WM integrity measurements suggest DTI might be promising neuroimaging tool for early detection of aMCI and AD patients.

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White Matter Integrity Determined With Diffusion Tensor Imaging in Older Adults Without Dementia

Cited by 65 publications

References 44 publications

Mediterranean diet and preserved brain structural connectivity in older subjects

Mediterranean diet and preserved brain structural connectivity in older subjects

Measuring Cortical Connectivity in Alzheimer’s Disease as a Brain Neural Network Pathology: Toward Clinical Applications

[P3–369]: Diagnostic Validity of an Automated Probabilistic Tractography in Amnestic Mild Cognitive Impairment

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