White matter markers and predictors for subject-specific rTMS response in major depressive disorder

Ning, Lipeng; Rathi, Yogesh; Barbour, Tracy; Makris, Nikos; Camprodon, Joan A.

doi:10.1016/j.jad.2021.12.005

Cited by 23 publications

(17 citation statements)

References 48 publications

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“…A more precise parcellation system thus provides a more anatomically accurate and efficient means by which brain structure in individuals with pathological conditions can be assessed and monitored during treatment. Furthermore, the comparative approach is critical to brain circuit mapping using novel treatments in psychiatry such as transcranial magnetic stimulation ( Ning et al, 2022 ; Salerno et al, 2022 ). Overall, the scope of disorders that can be studied with this system of analysis demonstrates its feasibility, broad applicability, and versatility.…”

Section: Discussionmentioning

confidence: 99%

HOA2.0-ComPaRe: A next generation Harvard-Oxford Atlas comparative parcellation reasoning method for human and macaque individual brain parcellation and atlases of the cerebral cortex

et al. 2022

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Comparative structural neuroanatomy is a cornerstone for understanding human brain structure and function. A parcellation framework that relates systematically to fundamental principles of histological organization is an essential step in generating structural comparisons between species. In the present investigation, we developed a comparative parcellation reasoning system (ComPaRe), which is a formal ontological system in human and non-human primate brains based on the cortical cytoarchitectonic mapping used for both species as detailed by Brodmann. ComPaRe provides a theoretical foundation for mapping neural systems in humans and other species using neuroimaging. Based on this approach, we revised the methodology of the original Harvard-Oxford Atlas (HOA) system of brain parcellation to produce a comparative framework for the human (hHOA) and the rhesus monkey (mHOA) brains, which we refer to as HOA2.0-ComPaRe. In addition, we used dedicated segmentation software in the publicly available 3D Slicer platform to parcellate an individual human and rhesus monkey brain. This method produces quantitative morphometric parcellations in the individual brains. Based on these parcellations we created a representative template and 3D brain atlas for the two species, each based on a single subject. Thus, HOA2.0-ComPaRe provides a theoretical foundation for mapping neural systems in humans and other species using neuroimaging, while also representing a significant revision of the original human and macaque monkey HOA parcellation schemas. The methodology and atlases presented here can be used in basic and clinical neuroimaging for morphometric (volumetric) analysis, further generation of atlases, as well as localization of function and structural lesions.

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Section: Discussionmentioning

confidence: 99%

HOA2.0-ComPaRe: A next generation Harvard-Oxford Atlas comparative parcellation reasoning method for human and macaque individual brain parcellation and atlases of the cerebral cortex

et al. 2022

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“…Using NODDI offers an opportunity to understand rTMS treatment for CUD. This may be particularly interesting as NODDI could be developed into an indicator of a state‐of‐disorder and treatment‐outcome biomarker 12–14 …”

Section: Introductionmentioning

confidence: 99%

“…This may be particularly interesting as NODDI could be developed into an indicator of a state-of-disorder and treatment-outcome biomarker. [12][13][14] In this study, we wished to evaluate whether rTMS induces changes in white matter (WM) microstructure of brain circuits, related to substance abuse, after 2 weeks of rTMS treatment in CUD patients and to test whether baseline WM microstructure of those circuits could predict clinical improvement. To achieve this, we used longitudinal multi-shell diffusion-weighted imaging and NODDI analysis.…”

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confidence: 99%

Cortical and subcortical microstructure integrity changes after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and relates to clinical outcomes

Rasgado‐Toledo,

Issa‐Garcia,

Alcalá‐Lozano

et al. 2024

Addiction Biology

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Cocaine use disorder (CUD) is a worldwide public health condition that is suggested to induce pathological changes in macrostructure and microstructure. Repetitive transcranial magnetic stimulation (rTMS) has gained attention as a potential treatment for CUD symptoms. Here, we sought to elucidate whether rTMS induces changes in white matter (WM) microstructure in frontostriatal circuits after 2 weeks of therapy in patients with CUD and to test whether baseline WM microstructure of the same circuits affects clinical improvement. This study consisted of a 2‐week, parallel‐group, double‐blind, randomized controlled clinical trial (acute phase) (sham [n = 23] and active [n = 27]), in which patients received two daily sessions of rTMS on the left dorsolateral prefrontal cortex (lDLPFC) as an add‐on treatment. T1‐weighted and high angular resolution diffusion‐weighted imaging (DWI‐HARDI) at baseline and 2 weeks after served to evaluate WM microstructure. After active rTMS, results showed a significant increase in neurite density compared with sham rTMS in WM tracts connecting lDLPFC with left and right ventromedial prefrontal cortex (vmPFC). Similarly, rTMS showed a reduction in orientation dispersion in WM tracts connecting lDLPFC with the left caudate nucleus, left thalamus, and left vmPFC. Results also showed a greater reduction in craving Visual Analogue Scale (VAS) after rTMS when baseline intra‐cellular volume fraction (ICVF) was low in WM tracts connecting left caudate nucleus with substantia nigra and left pallidum, as well as left thalamus with substantia nigra and left pallidum. Our results evidence rTMS‐induced WM microstructural changes in fronto‐striato‐thalamic circuits and support its efficacy as a therapeutic tool in treating CUD. Further, individual clinical improvement may rely on the patient's individual structural connectivity integrity.

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“…As such, TMS would be appealing for the treatment of GD as well. However, while the antidepressant effect of rTMS in patients with drug-resistant early onset MD is widely recognized, the same cannot be said for GD, especially in those with concomitant chronic subcortical ischemic vascular disease, since the microstructural changes in prefrontal white matter have been recently found to negatively correlate with treatment response [ 42 ]. Indeed, although rTMS was found to be effective in the short term in GD with concomitant cerebrovascular pathology, the limited number of studies, variability in study design and protocol, and heterogeneous populations challenge conclusions in this population [ 43 ].…”

Section: Introductionmentioning

confidence: 99%

Challenging the Pleiotropic Effects of Repetitive Transcranial Magnetic Stimulation in Geriatric Depression: A Multimodal Case Series Study

et al. 2023

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Background: Although the antidepressant potential of repetitive transcranial magnetic stimulation (rTMS), the pleiotropic effects in geriatric depression (GD) are poorly investigated. We tested rTMS on depression, cognitive performance, growth/neurotrophic factors, cerebral blood flow (CBF) to transcranial Doppler sonography (TCD), and motor-evoked potentials (MEPs) to TMS in GD. Methods: In this case series study, six drug-resistant subjects (median age 68.0 years) underwent MEPs at baseline and after 3 weeks of 10 Hz rTMS on the left dorsolateral prefrontal cortex. The percentage change of serum nerve growth factor, vascular endothelial growth factor, brain-derived growth factor, insulin-like growth factor-1, and angiogenin was obtained. Assessments were performed at baseline, and at the end of rTMS; psychocognitive tests were also repeated after 1, 3, and 6 months. Results: Chronic cerebrovascular disease was evident in five patients. No adverse/undesirable effect was reported. An improvement in mood was observed after rTMS but not at follow-up. Electrophysiological data to TMS remained unchanged, except for an increase in the right median MEP amplitude. TCD and neurotrophic/growth factors did not change. Conclusions: We were unable to detect a relevant impact of high-frequency rTMS on mood, cognition, cortical microcircuits, neurotrophic/growth factors, and CBF. Cerebrovascular disease and exposure to multiple pharmacological treatments might have contributed.

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White matter markers and predictors for subject-specific rTMS response in major depressive disorder

Cited by 23 publications

References 48 publications

HOA2.0-ComPaRe: A next generation Harvard-Oxford Atlas comparative parcellation reasoning method for human and macaque individual brain parcellation and atlases of the cerebral cortex

HOA2.0-ComPaRe: A next generation Harvard-Oxford Atlas comparative parcellation reasoning method for human and macaque individual brain parcellation and atlases of the cerebral cortex

Cortical and subcortical microstructure integrity changes after repetitive transcranial magnetic stimulation therapy in cocaine use disorder and relates to clinical outcomes

Challenging the Pleiotropic Effects of Repetitive Transcranial Magnetic Stimulation in Geriatric Depression: A Multimodal Case Series Study

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