White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Shih, Chun Kuang; Chen, Chiao Ming; Varga, Viola; Shih, Liang Chen; Chen, Peng Ru; Lo, Shu Fang; Shyur, Lie‐Fen; Li, Sing Chung

doi:10.29219/fnr.v64.3609

Cited by 16 publications

(16 citation statements)

References 46 publications

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“…Both SGPT and SGOT are an indicator of tissue strain in the liver due to a high sugar level. A similar result was identified by Refaat et al, 2020 [ 35 ], Shih et al, 2020 [ 36 ], and Jiang et al, 2020 [ 37 ] who observed a reduction in ALT, AST, and ALP. The outcome shows the capability of I. batatas extract to exhibit a protective effect against the liver from ROS due to a high level of glucose.…”

Section: Discussionsupporting

confidence: 87%

“…The findings obtained in this review are shown in Table 1 , highlighting the beneficial effect of I. batatas as an anti-hyperglycemia agent [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ] and also a good regulator in dyslipidemic conditions [ 39 , 40 , 42 , 43 , 44 , 45 , 46 ]. A positive outcome in reducing plasma glucose level is witnessed as early as six days after treating diabetic rats with I. batatas extract [ 34 ], while 28 days of continuous treatment with I. batatas extract is considered an ideal duration for the extract to exhibit a maximum level of effect.…”

Section: Discussionmentioning

confidence: 88%

“…In contrast, disruption in IRS protein phosphorylation or impaired PI3K recruitment from the cytosol, which results in PI3K inactivation, causes insulin resistance, followed by diabetes. In this situation, the flavonoids from I. batatas are able to activate Akt [ 36 ]. Activation of Akt further stimulates the translation of GLUT4, which is mainly expressed in the insulin-responsive tissues.…”

Section: Resultsmentioning

confidence: 99%

“…Meanwhile, the findings obtained by all the researchers are almost identical to one another. In this case, all the studies reviewed show that I. batatas extract, regardless of the method of extraction, are able to reduce plasma glucose level, glycosylated protein, and increased level of insulin [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 ].…”

Section: Discussionmentioning

confidence: 99%

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Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia—A Systematic Review in Diabetic Retinopathy Context

Naomi

Bahari

Yazid

et al. 2021

IJMS

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Hyperglycemia is a condition with high glucose levels that may result in dyslipidemia. In severe cases, this alteration may lead to diabetic retinopathy. Numerous drugs have been approved by officials to treat these conditions, but usage of any synthetic drugs in the long term will result in unavoidable side effects such as kidney failure. Therefore, more emphasis is being placed on natural ingredients due to their bioavailability and absence of side effects. In regards to this claim, promising results have been witnessed in the usage of Ipomoea batatas (I. batatas) in treating the hyperglycemic and dyslipidemic condition. Thus, the aim of this paper is to conduct an overview of the reported effects of I. batatas focusing on in vitro and in vivo trials in reducing high glucose levels and regulating the dyslipidemic condition. A comprehensive literature search was performed using Scopus, Web of Science, Springer Nature, and PubMed databases to identify the potential articles on particular topics. The search query was accomplished based on the Boolean operators involving keywords such as (1) Beneficial effect OR healing OR intervention AND (2) sweet potato OR Ipomoea batatas OR traditional herb AND (3) blood glucose OR LDL OR lipid OR cholesterol OR dyslipidemia. Only articles published from 2011 onwards were selected for further analysis. This review includes the (1) method of intervention and the outcome (2) signaling mechanism involved (3) underlying mechanism of action, and the possible side effects observed based on the phytoconstiuents isolated. The comprehensive literature search retrieved a total of 2491 articles using the appropriate keywords. However, on the basis of the inclusion and exclusion criteria, only 23 articles were chosen for further review. The results from these articles indicate that I. batatas has proven to be effective in treating the hyperglycemic condition and is able to regulate dyslipidemia. Therefore, this systematic review summarizes the signaling mechanism, mechanism of action, and phytoconstituents responsible for those activities of I. batatas in treating hyperglycemic based on the in vitro and in vivo study.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia—A Systematic Review in Diabetic Retinopathy Context

Naomi

Bahari

Yazid

et al. 2021

IJMS

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“…In patients with T2DM, WSP tuber extract effectively reduced insulin resistance as well as fibrinogen, fasting plasma glucose, and low-density lipoprotein-cholesterol levels (Ludvik et al 2008 , 2003 ). The 30% tubers of WSP had lower plasma glucose, insulin, glucose area under the curve (AUC) in diabetic mice (Shih et al 2020 ), improve nutrition status and glycemic control in elderly diabetic patients (Chen et al 2019 ), and reduce energy and facilitate individual weight loss (Shih et al 2019 ). However, the whole WSP roots introduced to diabetic mice, resulting in an insignificant PI3K/AKT signal expression in skeletal muscle of diabetic mice.…”

Section: Introductionmentioning

confidence: 99%

Extract of white sweet potato tuber against TNF-α-induced insulin resistance by activating the PI3K/Akt pathway in C2C12 myotubes

et al. 2021

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Background White sweet potato (WSP; Ipomoea batatas L. Simon No. 1) has many potential beneficial effects on metabolic control and diabetes-related insulin resistance. The improvement of insulin resistance by WSP tuber extracts on glucose uptake were not investigated in C2C12 myoblast cells. Results WSP tuberous ethanol extract (WSP-E) was partitioned with ethyl-acetate and water to obtain ethyl-acetate layer (WSP-EA) and water layer (WSP-EW). The WSP-EA shows the highest total phenolic contents and highest antioxidant activity by Folin-Ciocalteu and (2,2-diphenyl-1-picryl-hydrazyl-hydrate, DPPH) assay, respectively. After low concentration horse serum on differentiation inducement of C2C12 myoblasts into mature myotubes, the cells were treated with TNF-α to induce insulin resistance. WSP-EA and WSP-EW extracts increased the uptake of fluorescence glucose analogue (2-[N-(7-nitrobenz-2-oxa-1, 3-diazol-4-yl) amino]-2-deoxy-d-glucose, 2-NBDG) in a dose-dependent manner as examined by flow cytometry. The WSP-EA enhanced glucose uptake by activation of phosphorylation of IR (pIR), IRS-1 (pIRS-1) and Akt (pAkt) involved in PI3K (phosphatidylinositol 3-kinase)/protein kinase B (Akt) pathway, also upregulated glucose transporter 4 (GLUT4) expression in myotubes. Conclusions WSP-EA enhanced the glucose uptake in C2C12 myotubes through upregulating the PI3K/Akt pathway. The in vitro data reveal that WSP tuber extracts has potential applications to improve insulin resistance in diabetes.

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Sweet Potato (Ipomoea batatas): An Intervention Food in Management of Food and Nutritional Security in South Asia

Waseem,

Saeed,

Khan

2023

Neglected Plant Foods of South Asia

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White sweet potato ameliorates hyperglycemia and regenerates pancreatic islets in diabetic mice

Cited by 16 publications

References 46 publications

Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia—A Systematic Review in Diabetic Retinopathy Context

Potential Effects of Sweet Potato (Ipomoea batatas) in Hyperglycemia and Dyslipidemia—A Systematic Review in Diabetic Retinopathy Context

Extract of white sweet potato tuber against TNF-α-induced insulin resistance by activating the PI3K/Akt pathway in C2C12 myotubes

Sweet Potato (Ipomoea batatas): An Intervention Food in Management of Food and Nutritional Security in South Asia

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