White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’

Silveira, Ana Caroline Silva; Rato, Luís; Oliveira, Pedro F.; Alves, Marco G.; Silva, Branca M.

doi:10.3390/molecules26133894

Cited by 7 publications

(6 citation statements)

References 27 publications

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“…To evaluate the protein nitration and lipid peroxidation, slot-blot was used, as described previously [ 52 ]. Each sample of epididymal protein extract was diluted to a concentration of 0.05 µg/µL, using phosphate buffer saline (PBS), and transferred to a polyvinylidene difluoride (PVDF) membrane.…”

Section: Methodsmentioning

confidence: 99%

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Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway

Diniz

Alves

Candeias

et al. 2022

IJMS

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Diabetes mellitus type 2 (T2DM) has been associated with alterations in the male reproductive tract, especially in the epididymis. Although it is known that T2DM alters epididymal physiology, disturbing mitochondrial function and favoring oxidative stress, the mechanisms remain unknown. Sirtuin 1 (SIRT1), peroxisome proliferators-activated receptor γ coactivator 1α (PGC-1α), and sirtuin 3 (SIRT3) are key regulators of mitochondrial function and inducers of antioxidant defenses. In this study, we hypothesized that the epididymal SIRT1/PGC-1α/SIRT3 axis mediates T2DM-induced epididymis dysfunction by controlling the oxidative profile. Using 7 Goto-Kakizaki (GK) rats (a non-obese model that spontaneously develops T2DM early in life), and 7 age-matched Wistar control rats, we evaluated the protein levels of SIRT1, PGC-1α, and SIRT3, as well as the expression of mitochondrial respiratory complexes. The activities of epididymal glutathione peroxidase (GPx), glutathione reductase (GR), superoxide dismutase (SOD), and catalase (CAT) were determined, as well as the epididymal antioxidant capacity. We also evaluated protein nitration, carbonylation, and lipid peroxidation in the epididymis. The T2DM rats presented with hyperglycemia and glucose intolerance. Epididymal levels of SIRT1, PGC-1α, and SIRT3 were decreased, as well as the expression of the mitochondrial complexes II, III, and V, in the T2DM rats. We found a significant decrease in the activities of SOD, CAT, and GPx, consistent with the lower antioxidant capacity and higher protein nitration and lipid peroxidation detected in the epididymis of the T2DM rats. In sum, T2DM disrupted the epididymal SIRT1/PGC-1α/SIRT3 pathway, which is associated with a compromised mitochondrial function. This resulted in a decline of the antioxidant defenses and an increased oxidative damage in that tissue, which may be responsible for the impaired male reproductive function observed in diabetic men.

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Section: Methodsmentioning

confidence: 99%

“…Protein carbonyl groups were evaluated by slot-blot as described by [ 52 ]. Samples were derivatized using 2,4-dinitrophenylhydrazine, as described previously [ 53 ].…”

Section: Methodsmentioning

confidence: 99%

Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway

Diniz

Alves

Candeias

et al. 2022

IJMS

Self Cite

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“…Prediabetes, which has blood glucose levels that are higher than normal but lower than those of diabetic patients, is reversible and less severe than DM [ 37 ]. The people in this state are also insulin resistant and/or glucose tolerant [ 38 ]. Approximately 50% of those with prediabetes will develop T2DM within seven years, and 83% will convert throughout the course of their lifetime, according to data analyses [ 39 ].…”

Section: Diabetic Status: Impact On World Healthmentioning

confidence: 99%

Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications

et al. 2023

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Diabetes mellitus (DM) is a metabolic disease characterized by abnormal blood glucose levels-hyperglycemia, caused by a lack of insulin secretion, impaired insulin action, or a combination of both. The incidence of DM is increasing, resulting in billions of dollars in annual healthcare costs worldwide. Current therapeutics aim to control hyperglycemia and reduce blood glucose levels to normal. However, most modern drugs have numerous side effects, some of which cause severe kidney and liver problems. On the other hand, natural compounds rich in anthocyanidins (cyanidin, delphinidin, malvidin, pelargonidin, peonidin, and petunidin) have also been used for the prevention and treatment of DM. However, lack of standardization, poor stability, unpleasant taste, and decreased absorption leading to low bioavailability have hindered the application of anthocyanins as therapeutics. Therefore, nanotechnology has been used for more successful delivery of these bioactive compounds. This review summarizes the potential of anthocyanins for the prevention and treatment of DM and its complications, as well as the strategies and advances in the delivery of anthocyanins using nanoformulations.

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“…Despite the fact that white tea has the highest concentration of phenolic compounds, there are limited studies on white tea in the literature compared with green and black tea, especially in terms of body weight. Studies have shown that white tea has positive effects on chronic diseases such as cardiovascular diseases, metabolic syndrome, and type 2 diabetes (LIczbiński & Bukowska, 2022; Pastoriza et al, 2017; Silveira et al, 2021). These positive effects have been associated with antioxidants (caffeine and theophylline), catechins, l ‐theanine, minerals (F, Mn, Cr), essential oils and other phenolic compounds in the white tea composition (Cooper, 2012; Pastoriza et al, 2017).…”

Section: White Tea and Body Weight Managementmentioning

confidence: 99%

White tea: Its history, composition, and potential effects on body weight management

Yılmaz

Tek²

2023

eFood

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Obesity is a rapidly rising global public health concern in both developed and developing countries. Tea components, especially caffeine and catechins, may have beneficial effects in the treatment of obesity. Tea is a widely consumed beverage all over the world and it is a significant part of the culture, especially in Asian countries. Among the tea types, white tea is the least processed and the content of catechins is higher than the others. Many studies have been conducted on tea's health effects, especially on weight management. The beneficial effects of the consumption of tea containing polyphenols and caffeine such as helping to maintain body weight and playing crucial roles in fat metabolism have been shown in many studies. While there are many studies on green tea in the literature, interestingly, studies conducted with white tea are insufficient but showed significant results. Considering the positive health effects of bioactive components in tea species, the results of studies with white tea may be promising. Tea components have many promising health effects; however, these effects are not clearly understood yet, particularly regarding body weight management mechanisms such as fat oxidation and thermogenesis. Therefore, further well‐planned preclinical and clinical research is required to understand the effectiveness and mechanisms of white tea on body weight.

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White Tea Intake Abrogates Markers of Streptozotocin-Induced Prediabetes Oxidative Stress in Rat Lungs’

Cited by 7 publications

References 27 publications

Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway

Type 2 Diabetes Induces a Pro-Oxidative Environment in Rat Epididymis by Disrupting SIRT1/PGC-1α/SIRT3 Pathway

Nanoformulations for the Delivery of Dietary Anthocyanins for the Prevention and Treatment of Diabetes Mellitus and Its Complications

White tea: Its history, composition, and potential effects on body weight management

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