Whole-body diffusion-weighted magnetic resonance imaging in the staging of oncological patients: comparison with positron emission tomography computed tomography (PET-CT) in a pilot study

Stecco, Alessandro; Romano, Giovanna; Negru, M.; Volpe, D.; Saponaro, A.; Costantino, S.; Sacchetti, Gianmauro; Inglese, Eugenio; Alabiso, Oscar; Carriero, Alessandro

doi:10.1007/s11547-008-0348-4

Cited by 42 publications

(48 citation statements)

References 15 publications

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“…Stecco et al (57) prospectively compared whole-body DWI to 18 F-FDG PET/CT for staging of 29 oncologic patients (malignant lymphoma: n 5 15; lung cancer: n 5 3; breast cancer: n 5 3; gastrointestinal cancer: n 5 3; kidney cancer: n 5 2; sarcoma: n 5 1, primitive neuroectodermal tumor: n 5 1; prostate cancer: n 5 1). Wholebody DWI was evaluated by 2 independent observers who were masked to the 18 F-FDG PET/CT findings.…”

Section: General Whole-body Oncologic Imagingmentioning

confidence: 99%

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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18 F-FDG PET is an established functional imaging modality for the evaluation of human disease. Diffusion-weighted MRI (DWI) is another rapidly evolving functional imaging modality that can be used to evaluate oncologic and nononcologic lesions throughout the body. The information provided by 18 F-FDG PET and DWI can be complementary, because the 2 methods are based on completely different biophysical underpinnings. This article will describe the basic principles, clinical applications, and limitations of DWI. In addition, the available evidence that correlates and compares 18 F-FDG PET and DWI will be reviewed. PET,usi ng the radiotracer 18 F-FDG, is an established functional imaging modality for a variety of oncologic and nononcologic (e.g., inflammatory and infectious) applications (1-3). The contribution of 18 F-FDG PET to medicine has been unmatched by any other functional imaging modality (4). At present, there is also growing interest in the application of diffusion-weighted MRI (DWI) in the body (5-7). DWI allows visualization and quantification of the mobility of water molecules and has many potential clinical applications. Importantly, although 18 F-FDG PET and DWI are both functional imaging modalities and provide a high lesion-to-background contrast, they are based on completely different biophysical and biochemical underpinnings. Therefore, the information provided by the 2 imaging modalities may be regarded as complementary. Given the developing applications of DWI, the increasing use of multimodality imaging (8), and the expected advent of fully integrated PET/MRI systems (9), knowledge of the characteristics, possibilities, and limitations of DWI technique is becoming increasingly important. This is true for both the imaging specialists and the clinicians who use these modalities. This article will review the basic principles, clinical applications, and limitations of DWI. Furthermore, the available evidence that correlates and compares 18 F-FDG PET with DWI will be reviewed.

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Section: General Whole-body Oncologic Imagingmentioning

confidence: 99%

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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“…18F-FDG PET and DWI are both functional imaging modalities and provide a high lesion-to-background contrast, although they are based on completely different biophysical and biochemical mechanisms (9)(10)(11)(12)(13).…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of whole body magnetic resonance imaging (Diffusion-weighted imaging and fat saturated T2-weighted imaging) in the evaluation of patients with newly diagnosed malignancies in comparison with positron emission tomography- computed tomogra

Öncel

Oncel²,

Karapolat

et al. 2014

Journal of the Belgian Society of Radiology

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Purpose: To evaluate the effectiveness of wb-Mri for the detection of primary and metastatic lesions in comparison to peT-cT in patients with newly diagnosed malignancies Material and Methods: in this prospective study, 36 patients were evaluated between august 2008 and october 2012. The findings of wb-Mri (dwi and fat saturated T2 weighted images) were compared to the findings of peT-cT regarding the primary lesions and metastasis. sensitivity, specificity, positive and negative predictive values were calculated. To assess the aggreement between peT-cT and wb-Mri, kappa analysis was performed. Results: The sensitivity, specificity, positive and negative predictive values for wb-dwi for the detection of primary and metastatic lesions in comparison to peT-cT were 96%, 89%, 97% and 84%, respectively.These are calculated as 96%, 56% , 90% and 77%, for fat-saturated T2w images. according to kappa analysis, the agreement between peT-cT and wb-dwi was excellent (κ = 0.83), but between peT-cT and fat-saturated T2 weighted images, it was moderate (κ = 0.58). Conclusion: providing both morphogical and functional data, wb-Mri with dwi is emerging as a promising alternative imaging tool in the evaluation of cancer patients and may become complementary to peT-cT in several clinical applications.

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“…[54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] Such a system would allow exploiting, in addition to the above discussed applications, the power of MR spectroscopy (MRS) to measure the regional biochemical content and to assess the metabolic status or the presence of neoplasia and other diseases in specific tissue areas. Until concurrent PET/MRI technologies for whole-body imaging become more mature and economically viable, other approaches for so-called sequential PET/MR imaging have been researched.…”

Section: Historical Development Of Pet/mrimentioning

confidence: 99%

“…201 Despite the fact that the clinical role of PET/MRI in clinical setting is controversial and has not been yet addressed properly, the prospective applications of a whole-body PET/ MRI system in clinical oncology have been explored in the literature. [54][55][56][57][58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] The potential of nanoparticle-based dual-modality PET/MRI contrast agents is also being investigated. Some scientific arguments on the advantages of simultaneous imaging of morphological and functional information using hybrid PET/MRI technology will improve tissue characterization.…”

Section: Clinical Relevance Of Pet/mrimentioning

confidence: 99%

An outlook on future design of hybrid PET/MRI systems

2011

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Early diagnosis and therapy increasingly operate at the cellular, molecular, or even at the genetic level. As diagnostic techniques transition from the systems to the molecular level, the role of multimodality molecular imaging becomes increasingly important. Positron emission tomography (PET) and magnetic resonance imaging (MRI) are powerful techniques for in vivo molecular imaging. The inability of PET to provide anatomical information is a major limitation of standalone PET systems. Combining PET and CT proved to be clinically relevant and successfully reduced this limitation by providing the anatomical information required for localization of metabolic abnormalities. However, this technology still lacks the excellent soft-tissue contrast provided by MRI. Standalone MRI systems reveal structure and function but cannot provide insight into the physiology and/or the pathology at the molecular level. The combination of PET and MRI, enabling truly simultaneous acquisition, bridges the gap between molecular and systems diagnosis. MRI and PET offer richly complementary functionality and sensitivity; fusion into a combined system offering simultaneous acquisition will capitalize the strengths of each, providing a hybrid technology that is greatly superior to the sum of its parts. A combined PET/MRI system provides both the anatomical and structural description of MRI simultaneously with the quantitative capabilities of PET. In addition, such a system would allow exploiting the power of MR spectroscopy (MRS) to measure the regional biochemical content and to assess the metabolic status or the presence of neoplasia and other diseases in specific tissue areas. This paper briefly summarizes state-of-the-art developments and latest advances in dedicated hybrid PET/MRI instrumentation. Future prospects and potential clinical applications of this technology will also be discussed.

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Whole-body diffusion-weighted magnetic resonance imaging in the staging of oncological patients: comparison with positron emission tomography computed tomography (PET-CT) in a pilot study

Abstract: The whole-body DWIBS protocol provided a fast whole-body examination with high specificity and NPV. One major bias of the study was the inclusion of patients with diffuse disease and advanced disease stage and the heterogeneity of the neoplastic diseases included.

Cited by 42 publications

References 15 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

The effectiveness of whole body magnetic resonance imaging (Diffusion-weighted imaging and fat saturated T2-weighted imaging) in the evaluation of patients with newly diagnosed malignancies in comparison with positron emission tomography- computed tomogra

An outlook on future design of hybrid PET/MRI systems

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Whole-body diffusion-weighted magnetic resonance imaging in the staging of oncological patients: comparison with positron emission tomography computed tomography (PET-CT) in a pilot study

Abstract: The whole-body DWIBS protocol provided a fast whole-body examination with high specificity and NPV. One major bias of the study was the inclusion of patients with diffuse disease and advanced disease stage and the heterogeneity of the neoplastic diseases included.

Cited by 42 publications

References 15 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

The effectiveness of whole body magnetic resonance imaging (Diffusion-weighted imaging and fat saturated T2-weighted imaging) in the evaluation of patients with newly diagnosed malignancies in comparison with positron emission tomography- computed tomogra

An outlook on future design of hybrid PET/MRI systems

Contact Info

Product

Resources

About

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications