Whole-Body MRI, Including Diffusion-Weighted Imaging, for the Initial Staging of Malignant Lymphoma

Kwee, Thomas C.; Ufford, Henriëtte Quarles van; Beek, F. J. A.; Takahara, Taro; Uiterwaal, Cuno S.P.M.; Bierings, Marc; Ludwig, Inge; Fijnheer, Rob; Nievelstein, Rutger A.J.

doi:10.1097/rli.0b013e3181afbb36

Cited by 112 publications

(86 citation statements)

References 35 publications

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“…Other studies have shown that the combination of DWI and T2-weighted imaging is better than T2-weighted imaging alone for the detection of prostate cancer (25,26). Although the use of DWI in other areas is less well established, its utility for primary tumor and metastasis detection and staging in several major cancers is under active investigation (27)(28)(29)(30)(31)(32)(33). Because of its high lesionto-background contrast, the additional value of DWI is expected to lie in the detection of (small) lesions that remain unnoticed on anatomic-based imaging and on functional imaging techniques with low spatial resolution such as SPECT and PET.…”

Section: Clinical Applications and Limitations Of Dwi General Diagnosmentioning

confidence: 99%

“…Another limitation of DWI is that the evaluation of structures close to the heart, such as mediastinal lymph nodes and the left liver lobe, may be compromised because of signal loss and artifacts due to severe tissue motion (33,(44)(45)(46). Nevertheless, MRI is a versatile imaging modality, and the addition of other sequences may improve the evaluation of the mediastinal lymph nodes (24,47) (Fig.…”

Section: Limitationsmentioning

confidence: 99%

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Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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18 F-FDG PET is an established functional imaging modality for the evaluation of human disease. Diffusion-weighted MRI (DWI) is another rapidly evolving functional imaging modality that can be used to evaluate oncologic and nononcologic lesions throughout the body. The information provided by 18 F-FDG PET and DWI can be complementary, because the 2 methods are based on completely different biophysical underpinnings. This article will describe the basic principles, clinical applications, and limitations of DWI. In addition, the available evidence that correlates and compares 18 F-FDG PET and DWI will be reviewed. PET,usi ng the radiotracer 18 F-FDG, is an established functional imaging modality for a variety of oncologic and nononcologic (e.g., inflammatory and infectious) applications (1-3). The contribution of 18 F-FDG PET to medicine has been unmatched by any other functional imaging modality (4). At present, there is also growing interest in the application of diffusion-weighted MRI (DWI) in the body (5-7). DWI allows visualization and quantification of the mobility of water molecules and has many potential clinical applications. Importantly, although 18 F-FDG PET and DWI are both functional imaging modalities and provide a high lesion-to-background contrast, they are based on completely different biophysical and biochemical underpinnings. Therefore, the information provided by the 2 imaging modalities may be regarded as complementary. Given the developing applications of DWI, the increasing use of multimodality imaging (8), and the expected advent of fully integrated PET/MRI systems (9), knowledge of the characteristics, possibilities, and limitations of DWI technique is becoming increasingly important. This is true for both the imaging specialists and the clinicians who use these modalities. This article will review the basic principles, clinical applications, and limitations of DWI. Furthermore, the available evidence that correlates and compares 18 F-FDG PET with DWI will be reviewed.

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Section: Clinical Applications and Limitations Of Dwi General Diagnosmentioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Kwee¹,

Takahara²,

Ochiai³

et al. 2010

J Nucl Med

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“…Combined 18 F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is the standard imaging modality for staging HL, but uses ionizing radiation which is potentially harmful to the unborn fetus [1,2]. Therefore, whole-body magnetic resonance imaging (MRI) was used instead as a radiation-free alternative [2,3]. The whole-body MRI examination, which consisted of coronal T1-weighted and coronal short inversion time inversion recovery (STIR) acquisitions, took 30 min and was well tolerated by the patient.…”

mentioning

confidence: 99%

“…Therefore, whole-body magnetic resonance imaging (MRI) was used instead as a radiation-free alternative [2,3]. The whole-body MRI examination, which consisted of coronal T1-weighted and coronal short inversion time inversion recovery (STIR) acquisitions, took 30 min and was well tolerated by the patient.…”

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confidence: 99%

Whole‐body MRI for staging Hodgkin lymphoma in a pregnant patient

2010

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A 34-year-old woman at 31 weeks of gestation was referred to our institution because of unexplained right cervical lymph node enlargement. Ultrasound examination (not shown) confirmed the presence of a pathologically enlarged right cervical lymph node with a short-axis diameter of 4-5 cm. Subsequent ultrasound-guided core-needle biopsy of the lymph node revealed nodular sclerosing Hodgkin lymphoma (HL). Combined 18 F-fluoro-2-deoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) is the standard imaging modality for staging HL, but uses ionizing radiation which is potentially harmful to the unborn fetus [1,2]. Therefore, whole-body magnetic resonance imaging (MRI) was used instead as a radiation-free alternative [2,3]. The whole-body MRI examination, which consisted of coronal T1-weighted and coronal short inversion time inversion recovery (STIR) acquisitions, took 30 min and was well tolerated by the patient. Whole-body MRI showed right cervical lymph node involvement and mediastinal lymph node involvement, indicating stage II disease (Image 1). Because of advanced pregnancy and stage II disease confined to above the diaphragm, it was decided to postpone start of chemotherapy after child delivery. In conclusion, the presented case nicely demonstrates the utility of whole-body MRI as a radiation-free alternative to FDG-PET/CT for staging a pregnant patient with malignant lymphoma.

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“…Their results suggest that in the initial staging of malignant lymphoma, whole-body MRI (with and without DWI) provides similar results in the majority of patients to staging using CT. Indeed whole-body MRI never understaged relative to CT and usually correctly overstaged relative to CT, with a possible advantage of using DWI [2].…”

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confidence: 99%

From multislice CT to whole-body biomarker imaging in lymphoma patients

Bazelaire

Kerviler

2010

Eur Radiol

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Whole-Body MRI, Including Diffusion-Weighted Imaging, for the Initial Staging of Malignant Lymphoma

Cited by 112 publications

References 35 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Whole‐body MRI for staging Hodgkin lymphoma in a pregnant patient

From multislice CT to whole-body biomarker imaging in lymphoma patients

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Whole-Body MRI, Including Diffusion-Weighted Imaging, for the Initial Staging of Malignant Lymphoma

Cited by 112 publications

References 35 publications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and18F-FDG PET: The State of the Art and Potential Applications

Whole‐body MRI for staging Hodgkin lymphoma in a pregnant patient

From multislice CT to whole-body biomarker imaging in lymphoma patients

Contact Info

Product

Resources

About

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications

Complementary Roles of Whole-Body Diffusion-Weighted MRI and¹⁸F-FDG PET: The State of the Art and Potential Applications