Whole Fruit Phytochemicals Combating Skin Damage and Carcinogenesis

Abstract

Skin is arguably the largest organ of the body and is continuously subjected to intrinsic, extrinsic, and environmental stresses. Therefore, skin developed elaborate mechanisms to maintain homeostasis, including antioxidant, antiinflammatory, and DNA damage repair capabilities. However, repeated and excessive stresses can overwhelm these systems, causing serious cutaneous damages, including skin carcinogenesis. Phytonutrients present in the diet possess a myriad of health-promoting effects by protecting skin from damaging free radicals as well as by other mechanisms. Although many chemoprotective phytonutrients have been shown to be efficacious individually, a combination of multiple agents could have synergistic response in curtailing or preventing cutaneous damages. Here, we discuss the benefits of natural amalgamation of phytonutrients in select fruits against skin damage including carcinogenesis. However, a majority of these studies have been done in preclinical models. Therefore, clinical studies are needed to determine the human relevance of the available preclinical data, especially in the human population who are at higher risk for skin cancers (e.g., organ transplant patients). In addition, detailed well-structured preclinical animal studies in the models of high-risk skin carcinogenesis could also be useful toward informing the design for human trials.

Evaluation of the Phenolic Content, Antioxidant and Antimicrobial Activities of Oil and Non-Oil Extracts of Citrus sinensis (L.) Osbeck Seeds

“…They are known to be useful against diseases linked to free radicals, DNA damage and carcinogenesis as well as in the prevention of oxidative reactions in foods. They are also believed to possess anti-inflammatory and antimicrobial properties ( Zhang et al, 2015 ; Lee et al, 2017 ; Mintie et al, 2020 ). Several plants and plant parts hold promise as rich reservoirs of antimicrobial compounds and thus, require sustained pharmacological investigations.…”

Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

“…PCa incidence increases with age, which makes it more difficult to manage this disease. Recent studies demonstrating the beneficial effect of modifying dietary habits have been suggested to manage multiple diseases, including PCa [ 3 , 62 , 63 ]. Here, we found that dietary supplementation with the grape antioxidants quercetin and resveratrol together had significant antitumor effects against PCa in both prevention and intervention settings.…”

Dietary Habits and their Association with Metabolic Syndrome in a sample of Iranian adults: A population‐based study

“…For physical activity ascertainment, the Iranian Short Version of International Physical Activity Questionnaire (IPAQ) was given to the participants (Hu, 2002; Moghaddam et al., 2012). Physical activity levels of each participant were categorized as active and inactive based on the guideline of the short form of IPAQ (Mintie et al., 2020).…”