Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma

Brodtkorb, Marianne; Lingjærde, Ole Christian; Huse, Kanutte; Trøen, Gunhild; Hystad, Marit E.; Hilden, Vera; Myklebust, June Helen; Leich, Ellen; Rosenwald, Andreas; Delabie, Jan; Holte, Harald; Smeland, Erlend B.

doi:10.1182/blood-2013-07-512392

Cited by 49 publications

(33 citation statements)

References 24 publications

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“…22 Similarly, the observation that a small gene expression panel based on components of the nuclear factor kB (NF-kB) pathway components is predictive of HT may directly reflect the recent sequencing data showing that HT is frequently accompanied by mutations in genes encoding components of the NF-kB pathway, as mutations affecting the NF-kB pathway appear to be among the most consistent of the stepwise changes that ultimately lead to clinically recognizable HT. 3,23 Summary: biology of transformation…”

Section: Predictors Of Riskmentioning

confidence: 99%

Transformed follicular non-Hodgkin lymphoma

Casulo

Burack

Friedberg

2015

Blood

140

116

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Histologic transformation of follicular lymphoma to an aggressive non-Hodgkin lymphoma is a critical biologic event with profound implications on the natural history of this otherwise indolent disease. Recent insights into the genetic and epigenetic basis of transformation have been described, with the recognition of pivotal events governing the initiation and persistence of tumor evolution. Outcomes of patients with transformed lymphoma have historically been poor; however, several studies in the rituximab era suggest that survival may be more favorable than previously recognized. This review highlights our current understanding of transformed follicular lymphoma biology and pathogenesis, current treatment, and future directions.

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Section: Predictors Of Riskmentioning

confidence: 99%

Transformed follicular non-Hodgkin lymphoma

Casulo

Burack

Friedberg

2015

Blood

140

116

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“…A Phase I study [30] revealed a response rate of 36% in follicular lymphoma, as compared with 69-75% in the CLL, Waldenström's macroglobulinemia, and MCL histology subgroups. The ultimate course of follicular lymphoma, namely its transformation into aggressive NHL, is associated with the upregulation of NF-kB regulating genes, including BTK [38,39]. However, as transformed follicular lymphoma patients are often excluded from follicular lymphoma trials, no data on ibrutinib therapy in this particular setting is available to date.…”

Section: Follicular Lymphomamentioning

confidence: 96%

Bruton's tyrosine kinase inhibitors

Ysebaert¹,

Michallet²

2014

Current Opinion in Oncology

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“…Immune response 1 profile was found to be associated with a favorable survival prediction compared to the second immune response profile [48]. Recent analyses of copy number alterations (CNA) and gene mutation have provided greatly increased information on the pathogenesis and progression of FL [49][50][51]. This includes frequent abnormalities of genes involved in chromatin modification.…”

Section: Follicular Lymphomamentioning

confidence: 97%

Gene Expression Profiling in Non-Hodgkin Lymphomas

Song

Chan

2015

Non-Hodgkin Lymphoma

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Although the current WHO classification (Swerdlow et al. WHO classification of tumours of haematopoietic and lymphoid tissues. International Agency for Research on Cancer, Lyon, 2008 [1]) for hematolymphoid neoplasms has delineated lymphomas based on the combined morphologic, immunophenotypic, and genotypic findings, further refinement is necessary especially in regard to therapeutics and prognostic implications. High-throughput gene expression profiling (GEP) using microarray technology (Schena et al. Science 270:467-470, 1995 [2]; Augenlicht et al. Proc Natl Acad Sci USA 88:3286-3289, 1991 [3]) was developed about 20 years ago, and further refinement of the technology and analytical approaches has enabled us to routinely evaluate practically the entire transcriptome at a time. GEP has helped to improve the classification and prognostication of non-Hodgkin lymphomas (NHL) as well as improved our understanding of their pathophysiology and response to new therapeutics. In this paper, we will briefly review how this revolutionary tool has transformed our understanding of lymphomas and given us insight into targeted therapeutics. We will also discuss the current efforts in adapting the findings to routine clinical practice, the evolution of the research technology and directions in the future.

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Whole-genome integrative analysis reveals expression signatures predicting transformation in follicular lymphoma

Abstract: Key Points Whole-genome integrative analyses in FL reveal that genes strongly influenced by copy number are highly enriched for NF-kB pathway regulators. Subsignatures of the NF-kB targets predict transformation in FL.

Cited by 49 publications

References 24 publications

Transformed follicular non-Hodgkin lymphoma

Transformed follicular non-Hodgkin lymphoma

Bruton's tyrosine kinase inhibitors

Gene Expression Profiling in Non-Hodgkin Lymphomas

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