Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

Dempsey, Laurie A; Cooper, Robert J.; Powell, Samuel; Edwards, Andrea; Lee, Chuen-Wai; Brigadoi, Sabrina; Everdell, Nick; Arridge, Simon R.; Gibson, AP; Austin, Topun; Hebden, Jeremy C.

doi:10.1364/ecbo.2015.953818

Cited by 5 publications

(4 citation statements)

References 18 publications

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“…It is only since the turn of the century that neuroimaging studies have offered definitive proof of the changes in the brain during infant learning. This includes cognitive development such as typical growth rate, myelination, top-down modulation, and changes in cortical hubs, (Deoni et al, 2011;Fransson et al, 2011;Holland et al, 2014;Dempsey et al, 2015;Emberson et al, 2015). While teachers and parents generally understand that infants learn at an astounding rate, few are aware that infants have a preverbal early number sense that permits them to estimate quantities, gauge relative size and judge spatial orientation (Dehaene, 2011).…”

Section: Part Ii: Learning Trajectories and Radical Neuroconstructivismmentioning

confidence: 99%

Radical neuroconstructivism: a framework to combine the how and what of teaching and learning?

Tokuhama-Espinosa

Borja

2023

Front. Educ.

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Recent advances in pedagogical research have called attention to the dynamic nature of the teaching and learning process in which the actors mutually influence one another. The understanding of how this works in the brain—the specialized neural networks related to this process—is often limited to neuroscientists but are slowly becoming available to other learning scientists, including teachers. A transdisciplinary approach combining the best information about observable teaching-learning processes from education with newer information from the neurosciences may aid in resolving fundamental questions in the learning process. Teachers’ professional formation and development is often structured in segmented topical ways (e.g., pedagogy, evaluation, planning, classroom management, social–emotional learning), to identify important content knowledge (e.g., art, reading, mathematics, STEM), or to appreciate life skills (e.g., collaboration, critical thinking, social–emotional learning). While important, knowledge about the brain, the organ responsible for learning, is typically absent from teacher education. This paper reexamines the evidence from neuroconstructivism and the hierarchy of learning trajectories and combines it with evidence from psychology and the ways humans interact during the teaching-learning process to suggest radical neuroconstructivism as a framework within which to organize teachers’ professional development. The radical neuroconstructivism framework may contribute to making the content knowledge of teachers’ continual professional development more visible.

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Section: Part Ii: Learning Trajectories and Radical Neuroconstructivismmentioning

confidence: 99%

Radical neuroconstructivism: a framework to combine the how and what of teaching and learning?

Tokuhama-Espinosa

Borja

2023

Front. Educ.

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“…This system is based on a commercial SCL with an AOTF filtering and has 32 channels based on TCSPC. It was successfully used to scan healthy and ill infants in a clinical environment [88,89], an example of data produced by this system is provided in Figure 3. More recently, a new TD-DOT system based on a commercial SCL filtered by an AOTF, and a 32 × 32-pixel SPAD camera, has been developed by a team at the Biomedical Optics Research Laboratory at the University of Zurich [26,27,90].…”

Section: Novel Instrument Developementmentioning

confidence: 99%

The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging

2021

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Optical techniques based on diffuse optics have been around for decades now and are making their way into the day-to-day medical applications. Even though the physics foundations of these techniques have been known for many years, practical implementation of these technique were hindered by technological limitations, mainly from the light sources and/or detection electronics. In the past 20 years, the developments of supercontinuum laser (SCL) enabled to unlock some of these limitations, enabling the development of system and methodologies relevant for medical use, notably in terms of spectral monitoring. In this review, we focus on the use of SCL in biomedical diffuse optics, from instrumentation and methods developments to their use for medical applications. A total of 95 publications were identified, from 1993 to 2021. We discuss the advantages of the SCL to cover a large spectral bandwidth with a high spectral power and fast switching against the disadvantages of cost, bulkiness, and long warm up times. Finally, we summarize the utility of using such light sources in the development and application of diffuse optics in biomedical sciences and clinical applications.

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“…More recently, the UCL team reported the development of the second generation of the TD-DOT-NIRS MONSTIR, called MONSTIR II [68]. Dempsey and colleagues [73] reported to have successfully scanned a healthy infant with MONSTIR II. This work was largely exploratory to demonstrate the quality of the recording of the data acquired with MONSTIR II in a clinical environment.…”

Section: Neonatologymentioning

confidence: 99%

“…Finally, Fujisaka and colleagues [115] using the latest TD-NIRS device developed by Hamamatsu (a two-channel tNIRS-1) reported in one patient a decrease in brain [HbT] and StO 2 during circulatory arrest in cardiac surgery. Hintz et al [62] 1998 N = 1 (0) In-house (6) DOT x Hintz et al [63] 1999 N = 6 (0) In-house (6) DOT x Hintz et al [64] 1999 N = 6 (0) In-house (6) DOT x Benaron et al [65] 2000 N = 2 (0) In-house (6) DOT x x Hintz et al [64] 2001 N = 2 (0) In-house (6) DOT x x x Hebden et al [70] 2002 N = 3 (0) In-house 7DOT x x x x Hebden et al [71] 2004 N = 1 (0) In-house 7DOT x x x x Ijichi et al [80] 2005 N = 22 (0) TRS-10 (1) Fitting x x x x x x x Austin et al [72] 2006 N = 24 (0) In-house 7DOT x x x Gibson et al [69] 2006 N = 6 (0) In-house 7DOT x x x x x Hoshino et al [79] 2010 N= 1 (0) TRS-10 (1) Fitting x x x x Koyano et al [75] 2013 [77] 2014 N = 72 (0) TRS-20 (1) Fitting x x Ishii et al [76] 2014 N = 87 (0) TRS-20 (1) Fitting x x Nakamura et al [78] 2015 N = 11 (0) TRS-10 (1) Fitting x x Dempsey et al [73] 2015 N = 1 (0) In-house (8) Moments x Spinelli et al [81] 2017 [87] 2011 N =11 (0) In-house (13) Moments x Steinkellner et al [86] 2012 N =10 (0) In-house (12) Moments x Liebert et al [85] 2012 N = 2 (2) In-house (11) Moments x Sato et al [91] 2018 N = 5 (0) TRS-20 (2) Fitting x x x x x Giacalone et al [88] 2019 N = 47 (35) In-house (14) Fitting [94] 2017 N = 11 (0) NIRO-TRS1 (5) Fitting x x Lanks et al [95] 2018 N = 1 (0) NIRO-TRS1 (5) Fitting x x x x Weigl et al [97] 2018 N = 28 (9) In-house (17) Moments x Shinba et al …”

Section: Peroperative Carementioning

confidence: 99%

Clinical Brain Monitoring with Time Domain NIRS: A Review and Future Perspectives

Lange

Tachtsidis

2019

Applied Sciences

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Near-infrared spectroscopy (NIRS) is an optical technique that can measure brain tissue oxygenation and haemodynamics in real-time and at the patient bedside allowing medical doctors to access important physiological information. However, despite this, the use of NIRS in a clinical environment is hindered due to limitations, such as poor reproducibility, lack of depth sensitivity and poor brain-specificity. Time domain NIRS (or TD-NIRS) can resolve these issues and offer detailed information of the optical properties of the tissue, allowing better physiological information to be retrieved. This is achieved at the cost of increased instrument complexity, operation complexity and price. In this review, we focus on brain monitoring clinical applications of TD-NIRS. A total of 52 publications were identified, spanning the fields of neonatal imaging, stroke assessment, traumatic brain injury (TBI) assessment, brain death assessment, psychiatry, peroperative care, neuronal disorders assessment and communication with patient with locked-in syndrome. In all the publications, the advantages of the TD-NIRS measurement to (1) extract absolute values of haemoglobin concentration and tissue oxygen saturation, (2) assess the reduced scattering coefficient, and (3) separate between extra-cerebral and cerebral tissues, are highlighted; and emphasize the utility of TD-NIRS in a clinical context. In the last sections of this review, we explore the recent developments of TD-NIRS, in terms of instrumentation and methodologies that might impact and broaden its use in the hospital.

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Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

Cited by 5 publications

References 18 publications

Radical neuroconstructivism: a framework to combine the how and what of teaching and learning?

Radical neuroconstructivism: a framework to combine the how and what of teaching and learning?

The Use of Supercontinuum Laser Sources in Biomedical Diffuse Optics: Unlocking the Power of Multispectral Imaging

Clinical Brain Monitoring with Time Domain NIRS: A Review and Future Perspectives

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