Whole Heart Modeling and Computer Simulation

Computer Simulation of Clinical Electrophysiological Study

“…In addition to the induction of SVT, we also conducted the simulation of the termination of SVT by using extrastimulus 15 . Initially, we reproduced an SVT by setting a premature atrial stimulus with a coupling interval of 270 ms from the previous sinus pacing in the model of the heart with the WPW syndrome so as to reproduce a reentry circuit.…”

“…In addition to the induction of SVT, we also conducted the simulation of the termination of SVT by using extrastimulus. 15 Initially, we reproduced an SVT by setting a premature atrial stimulus with a coupling interval of 270 ms from the previous sinus pacing in the model of the heart with the WPW syndrome so as to reproduce a reentry circuit. The simulated reentry circuit was composed of one limb of the antegrade conduction via the AV node and the other limb of the retrograde conduction via the Kent bundle.…”

“…The heart models employed in this research were based on the Wei-Harumi model, which has been developed by our research group to simulate the body surface ECG with anatomical and electrophysiological settings at a wholeheart level. 15 The model comprises about 50,000 normal model cells such as the sinus node, atria, AV node, His bundle, bundle branch, Purkinje fiber, and ventricle; other specified model cells, known as user-defined types, can be defined by modifying their electrophysiological parameters. The electrophysiological parameters of model cells are associated with the action potential, CV, automaticity, and pacing.…”

“…In this research, we extended the implementation of heart models to simulate pacing in EPS based on our previous research on calculating intracardiac potentials 11 . As case studies, we employed a model of the normal heart and a model of the heart with the WPW syndrome (Type A) modified from the Wei‐Harumi model 15 to simulate the corresponding excitation propagation in the heart and the intracardiac electrograms that would be measured with catheter electrodes during the delivering of different EPS pacing protocols. Accordingly, we reproduced some typical EPS procedures, such as the determination of the refractory period, the induction of a Wenckebach pattern, the induction and termination of supraventricular tachycardia (SVT) due to the reentrant loop in the model of the heart with the WPW syndrome, and the localization of an accessory pathway in the same model 16,17 .…”

Electrocardiographic simulation on personalised heart-torso structures using coupled meshfree-BEM platform

“…Secondly, more details need to be included into the heart model. Locations of earliest ventricular excitation, determined by the distribution of Purkinje network in the ventricles, is known to greatly influence the ventricular excitation and the resulting BSP (Wei, 2004). Because it is not possible to identify the Purkinje fibre from image data, it is a common way to determine the locations of earliest ventricular excitation according to experimental studies (Durrur et al, 1970).…”