Whole transcriptome analysis identifies full-length genes for neoandrographolide biosynthesis from Andrographis alata, an alternate source for antiviral compounds

Tanuja, Gupta; Parani, Madasamy

doi:10.1016/j.gene.2022.146981

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…Andrographolide, which is abundant in A. paniculata , has antipyretic, anti-inflammatory and antiviral effects [ 35 ]. It is currently mainly produced by the extraction from plants [ 36 ] and biosynthesis of andrographolide by microbial fermentation would enable more sustainable production.…”

Section: Discussionmentioning

confidence: 99%

Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae

Li,

Luo,

Yin

et al. 2024

Synthetic and Systems Biotechnology

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Section: Discussionmentioning

confidence: 99%

Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae

Li,

Luo,

Yin

et al. 2024

Synthetic and Systems Biotechnology

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“…Serpentinine was identified as the most potent antiviral agent against SARS-CoV-2 main protease and non-structural protein 16 among the 1916 compounds screened [114]. In contrast, neoandrographolide, a major antiviral component of Andrographis alata [115], exhibits antiviral activity against various viruses, including SARS-CoV-2 [116,117], Zika virus [118], and herpes simplex virus-1 [119]. Neoandrographolide also possesses anti-inflammatory, anticancer, hepatoprotective, and antiradical properties [120].…”

Section: Natural Source-derived Niv Inhibitorsmentioning

confidence: 99%

Breaking the chains: Advancements in antiviral strategies to combat Nipah virus infections

Orosco

2023

Int J One Health

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Nipah virus (NiV) is a highly pathogenic zoonotic virus that has caused several outbreaks with high fatality rates in humans and animals, thus, requiring a “One Health” approach. No specific treatment or vaccine is available for NiV infection, making the development of effective antiviral agents against this virus a critical research priority. In recent years, significant efforts have been made to identify and develop antiviral agents targeting the various stages of NiV pathogenesis. This review comprehensively discusses current research on antiviral agents against NiV. The promising results obtained with several compounds, including repurposed drugs, nucleoside analogs, phytochemicals, and multi-target inhibitors, are also highlighted. Developing effective antiviral agents against NiV remains a major challenge; however, recent advances in understanding the mechanisms of NiV pathogenesis and identifying potential targets for antiviral agents have provided hope for the future. Further research is required to identify and optimize antiviral agents with broad-spectrum activity against NiV and other related viruses.

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Transcriptome sequencing and identification of full-length genes involved in the biosynthesis of anticancer compounds Oleanolic acid and Ursolic acid in Achyranthes aspera L.

Jeevitha,

Ravichandiran,

Tanuja

et al. 2025

Gene

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Whole transcriptome analysis identifies full-length genes for neoandrographolide biosynthesis from Andrographis alata, an alternate source for antiviral compounds

Cited by 4 publications

References 33 publications

Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae

Screening of ent-copalyl diphosphate synthase and metabolic engineering to achieve de novo biosynthesis of ent-copalol in Saccharomyces cerevisiae

Breaking the chains: Advancements in antiviral strategies to combat Nipah virus infections

Transcriptome sequencing and identification of full-length genes involved in the biosynthesis of anticancer compounds Oleanolic acid and Ursolic acid in Achyranthes aspera L.

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