Whole‐tumor apparent diffusion coefficient measurements in nephroblastoma: Can it identify blastemal predominance?

Littooij, Annemieke S.; Sebire, Neil J.; Olsen, Øystein E.

doi:10.1002/jmri.25506

Cited by 27 publications

(32 citation statements)

References 15 publications

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“…With this limited number of lesions, we found a strong linear relationship between the stromal proportion at histopathology and median ADC. Our results replicate previous studies in 25 patients [ 4 , 5 ]. However with side-by-side comparison of MR images and histopathology findings, the current reported linear relationship is more apparent.…”

Section: Discussionsupporting

confidence: 93%

“…Unfortunately only limited proportions of the epithelial subtype were present in our current reported study. Therefore potential linear relationship between 25th percentile ADC and percentage of blastemal components might be overestimated because both blastema and epithelial predominant lesions demonstrate relatively low ADC values [ 4 , 5 ]. Furthermore the overall effect in a group of tumours cannot be directly extrapolated to the individual patient.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, chemo-resistant blastemal subtype after preoperative treatment has prognostic value with respect to event-free and overall survivial [ 1 , 2 ]. MRI with DWI might be of value to assess both tumour response to treatment and ADC values in residual viable parts of lesions [ 5 ]. The combination of evident tumour shrinkage or necrosis with relative low ADC values in viable tumour components could be suggestive of chemo-resistant blastema [ 4 , 5 ].…”

Section: Discussionmentioning

confidence: 99%

“…The ability to identify high-risk histopathological subtypes (such as blastema-predominant lesions after preoperative treatment) might enable more personalized treatment decisions in the future [ 2 , 3 ]. The addition of diffusion-weighted imaging (DWI) to the standard MRI protocol might provide information regarding subtype characterisation and treatment response beyond necrosis and volume change [ 1 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies compared whole-tumour apparent diffusion coefficient (ADC) measurements with post-resection whole-tumour histopathological assessment [ 4 , 5 ]. These studies reported a relationship between ADC markers and stromal subtype histopathology.…”

Section: Introductionmentioning

confidence: 99%

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Apparent diffusion coefficient as it relates to histopathology findings in post-chemotherapy nephroblastoma: a feasibility study

et al. 2017

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Background Nephroblastomas represent a group of heterogeneous tumours with variable proportions of distinct histopathological components. Objective The purpose of this study was to investigate whether direct comparison of apparent diffusion coefficient (ADC) measurements with post-resection histopathology subtypes is feasible and whether ADC metrics are related to histopathological components. Materials and methods Twenty-three children were eligible for inclusion in this retrospective study. All children had MRI including diffusion-weighted imaging (DWI) after preoperative chemotherapy, just before tumour resection. A pathologist and radiologist identified corresponding slices at MRI and postoperative specimens using tumour morphology, the upper/lower calyx and hilar vessels as reference points. An experienced reader performed ADC measurements, excluding non-enhancing areas. A pathologist reviewed the corresponding postoperative slides according to the international standard guidelines. We tested potential associations with the Spearman rank test. Results Side-by-side comparison of MRI-DWI with corresponding histopathology slides was feasible in 15 transverse slices in 9 lesions in 8 patients. Most exclusions were related to extensive areas of necrosis/haemorrhage. In one lesion correlation was not possible because of the different orientation of sectioning of the specimen and MRI slices. The 25% ADC showed a strong relationship with percentage of blastema (Spearman rho=−0.71, P=0.003), whereas median ADC was strongly related to the percentage stroma (Spearman rho=0.74, P=0.002) at histopathology. Conclusion Side-by-side comparison of MRI-DWI and histopathology is feasible in the majority of patients who do not have massive necrosis and hemorrhage. Blastemal and stromal components have a strong linear relationship with ADC markers.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Apparent diffusion coefficient as it relates to histopathology findings in post-chemotherapy nephroblastoma: a feasibility study

et al. 2017

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Characteristics and outcome of pediatric renal cell carcinoma patients registered in the International Society of Pediatric Oncology (SIOP) 93‐01, 2001 and UK‐IMPORT database: A report of the SIOP‐Renal Tumor Study Group

Beek

Hol

Coulomb-L’Herminé

et al. 2021

Intl Journal of Cancer

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In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology‐Renal Tumor Study Group (SIOP‐RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93‐01, 2001 and UK‐IMPORT databases, were included. Event‐free survival (EFS) and overall survival (OS) were analyzed using the Kaplan‐Meier method. Between 1993 and 2019, 122 pediatric patients with RCC were registered. Available detailed data (n = 111) revealed 56 localized, 30 regionally advanced, 25 metastatic and no bilateral cases. Histological classification according to World Health Organization 2004, including immunohistochemical and molecular testing for transcription factor E3 (TFE3) and/or EB (TFEB) translocation, was available for 65/122 patients. In this group, the most common histological subtypes were translocation type RCC (MiT‐RCC) (36/64, 56.3%), papillary type (19/64, 29.7%) and clear cell type (4/64, 6.3%). One histological subtype was not reported. In the remaining 57 patients, translocation testing could not be performed, or TFE‐cytogenetics and/or immunohistochemistry results were missing. In this group, the most common RCC histological subtypes were papillary type (21/47, 44.7%) and clear cell type (11/47, 23.4%). Ten histological subtypes were not reported. Estimated 5‐year (5y) EFS and 5y OS of the total group was 70.5% (95% CI = 61.7%‐80.6%) and 84.5% (95% CI = 77.5%‐92.2%), respectively. Estimated 5y OS for localized, regionally advanced, and metastatic disease was 96.8%, 92.3%, and 45.6%, respectively. In conclusion, the registered pediatric patients with RCC showed a reasonable outcome. Survival was substantially lower for patients with metastatic disease. This descriptive study stresses the importance of full, prospective registration including TFE‐testing.

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MRI Characteristics of Pediatric Renal Tumors: A SIOP‐RTSG Radiology Panel Delphi Study

Beek

Watson

Nievelstein

et al. 2021

Magnetic Resonance Imaging

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Background:The SIOP-Renal Tumor Study Group (RTSG) does not advocate invasive procedures to determine histology before the start of therapy. This may induce misdiagnosis-based treatment initiation, but only for a relatively small percentage of approximately 10% of non-Wilms tumors (non-WTs). MRI could be useful for reducing misdiagnosis, but there is no global consensus on differentiating characteristics. Purpose: To identify MRI characteristics that may be used for discrimination of newly diagnosed pediatric renal tumors. Study Type: Consensus process using a Delphi method. Population: Not applicable.

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Whole‐tumor apparent diffusion coefficient measurements in nephroblastoma: Can it identify blastemal predominance?

Abstract: 3 J. MAGN. RESON. IMAGING 2017;45:1316-1324.

Cited by 27 publications

References 15 publications

Apparent diffusion coefficient as it relates to histopathology findings in post-chemotherapy nephroblastoma: a feasibility study

Apparent diffusion coefficient as it relates to histopathology findings in post-chemotherapy nephroblastoma: a feasibility study

Characteristics and outcome of pediatric renal cell carcinoma patients registered in the International Society of Pediatric Oncology (SIOP) 93‐01, 2001 and UK‐IMPORT database: A report of the SIOP‐Renal Tumor Study Group

MRI Characteristics of Pediatric Renal Tumors: A SIOP‐RTSG Radiology Panel Delphi Study

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