Long-standing discussions of the so-called urban–rural divide in the United States have uncovered meaningful differences between urbanites and rural residents, but much of this work has focused on political attitudes. However, there is reason to believe that geographic divides also influence Americans’ science attitudes, including, for example, positive affect toward scientists and levels of trust in them. Unfortunately, existing work has not clearly ruled out confounding factors such as religiosity, political views, media habits, and conspiracism. This brief article addresses this problem by drawing on survey data from 2016 to test the hypothesis that rural residency will be associated with colder feelings toward the scientific community, even with controls in place. The results offer support for this expectation. These findings lend support to recent arguments that rural Americans’ science attitudes are influenced by factors that go beyond demographics, conspiracism, political polarization, differences of religiosity, and (partisan) media consumption.