Why do all lariat RNA introns have adenosine as the branch point nucleotide ? Conformational studies on the implication of the branch-point modification by guanine, uracil or cytosine in the naturally.occurring branched tetranucleotide by 1H- &amp; 31p-NMR spectroscopy

Remaud, Gérald S.; Balgobin, N.; Glemarec, C.; Chattopadhyaya, J.

doi:10.1016/0040-4020(89)80152-8

Cited by 13 publications

(1 citation statement)

References 37 publications

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“…Tridecanedioic acid monopotassium salt prepared from tridecanedioic acid ( 6 ) with an equimolar amount of potassium hydroxide was transformed to its monobenzyl ester ( 7 ) in 68% yield (Scheme 1) . The monoester 7 was converted into terminal olefinic ester 8 by oxidative decarboxylation using lead tetraacetate and a catalytic amount of cupric acetate .…”

Section: Resultsmentioning

confidence: 99%

Novel Acyl α-Pyronoids, Dictyopyrone A, B, and C, from Dictyostelium Cellular Slime Molds

et al. 2000

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For the elucidation of the diversity of secondary metabolites of Dictyostelium cellular slime molds, we investigate the constituent of three species of slime molds. From the methanol extract of their fruit bodies, we obtained three novel compounds, dictyopyrone A (1) and B (2) from D. discoideum and D. rhizoposium and dictyopyrone C (3) from D. longosporum. They possess a unique alpha-pyrone moiety with a side chain at the C-3 position. Their relative structures were elucidated by spectral means, and the absolute configuration was confirmed by asymmetric synthesis of 1. Since these compounds were obtained from different species of Dictyostelium slime molds, they may be a type of compound common to this genus.

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Section: Resultsmentioning

confidence: 99%

Novel Acyl α-Pyronoids, Dictyopyrone A, B, and C, from Dictyostelium Cellular Slime Molds

et al. 2000

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Synthetic and conformational studies of branched and lariat RNAs. Modelling the lariat formed in the splicing reaction — A critical review

Sund

Glemarec

Chattopadhyaya

1994

Proc. Indian Acad. Sci. (Chem. Sci.)

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The formation of lariat RNAs in eukaryotes plays a central role in the transmission of genetic information into protein products through the synthesis of the processed RNA. The biomimetic synthetic models (branched and lariat RNAs) of the lariat RNA intron formed in the penultimate step of group 11 and nuclear pre-mRNA processing reaction (splicing) in eukaryotes have been used in structural studies (NMR) to understand its biological importance. Some of the synthetic lariat RNAs also function as biomimetic models for study of the self-cleavage reaction taking place in natural ribozyme-RNA substrate complexes. This review deals with our work on the design and synthesis of model systems mimicking the biological lariat RNA. All the published works on chemical synthesis of branched and lariat oligo-RNAs have been covered in this paper with emphasis on our own extensive work. Our synthetic schemes of acyclic branched RNA trimers (_1-7__), tetramers (8-15), pentamers (16, 17), heptamer t8, nonamer 1_2, 9 decamer 20 and lariat RNA tetramer pentamer 22, hexamer 23 and heptamer 24 show how delicately one had to employ different sets of complementary protecting groups and phosphorylation techniques for the synthesis of the target RNAs. Despite the display of apparent complexity of these strategies, they all can be grouped under two general reaction routes. In the final section we have given a brief summary of the results of our structural studies on our synthetic branched RNAs using 500 and 600 MHz NMR spectroscopy.

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Solution structure of lariat RNA by 500 MHz NMR spectroscopy and molecular dynamics studies in water

Agback

Sandström

Yamakage

et al. 1993

Journal of Biochemical and Biophysical Methods

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Why do all lariat RNA introns have adenosine as the branch point nucleotide ? Conformational studies on the implication of the branch-point modification by guanine, uracil or cytosine in the naturally.occurring branched tetranucleotide by 1H- & 31p-NMR spectroscopy

Cited by 13 publications

References 37 publications

Novel Acyl α-Pyronoids, Dictyopyrone A, B, and C, from Dictyostelium Cellular Slime Molds

Novel Acyl α-Pyronoids, Dictyopyrone A, B, and C, from Dictyostelium Cellular Slime Molds

Synthetic and conformational studies of branched and lariat RNAs. Modelling the lariat formed in the splicing reaction — A critical review

Solution structure of lariat RNA by 500 MHz NMR spectroscopy and molecular dynamics studies in water

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