Why is polymyalgia rheumatica a disease of older adults? Explanations through etiology and pathogenesis: a narrative review

Benlidayı, İlke Coşkun

doi:10.1007/s10067-023-06708-3

Cited by 7 publications

(2 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We are intrigued by Coskun Benlidayi's review article in which the author proposed that immunosenescence/inflammaging, increased risk of infections with aging, endocrinosenescence, and age-related changes in gut microbiota are factors associated with polymyalgia rheumatica (PMR) and aging (1). We appreciate the views of Coskun Belindayi; however, the aforementioned factors are not exclusive to PMR.…”

Section: Sirsmentioning

confidence: 99%

Why would immuno- and endocrino-senescence, age-related changes in the gut microbiota, and susceptibility to infection favour polymyalgia rheumatica over seronegative elderly-onset rheumatoid arthritis?

Manzo,

Nune,

Castagna

2023

Clinical and Experimental Rheumatology

View full text Add to dashboard Cite

Section: Sirsmentioning

confidence: 99%

Why would immuno- and endocrino-senescence, age-related changes in the gut microbiota, and susceptibility to infection favour polymyalgia rheumatica over seronegative elderly-onset rheumatoid arthritis?

Manzo,

Nune,

Castagna

2023

Clinical and Experimental Rheumatology

View full text Add to dashboard Cite

“…Safer treatments are needed for this condition that primarily affects the elderly as well as early onset. [86][87][88][89][90]…”

Section: Future Perspectivesmentioning

confidence: 99%

Case Report and Literature Review of an Atypical Polymyalgia Rheumatica and Its Management

Ahmed,

Ahmad,

Pan

2023

IMCRJ

View full text Add to dashboard Cite

Polymyalgia rheumatica (PMR) is a systemic inflammatory disease of the elderly population that increases in incidence as age advances. It is characterised by the sudden or sub-acute onset of symptoms affecting the shoulder and pelvic girdles, often accompanied by constitutional symptoms. Due to the lack of consensual diagnostic criteria and specific laboratory or radiological investigations for PMR, its diagnosis can be very challenging, particularly because it can be mimicked or masked by other geriatric syndromes. PMR responds well to glucocorticoid treatment, but if left untreated, can lead to morbidity and poor quality of life. We present the case of an 87-year-old male who presented with a one-week history of localised pain in the left hip joint, later involving the contralateral hip. Previously able to ambulate unaided, his mobility was now severely impaired. Due to his Alzheimer’s dementia and multiple comorbid geriatric conditions, extensive investigations were undertaken before a diagnosis of atypical PMR was reached. Treatment with a low dose of prednisolone led to a full recovery. This case highlights the inconsistency between an atypical presentation and the classic presentation of PMR and draws attention to the possibility of missed diagnosis in older, frail patients. Atypical symptomatology on top of cognitive impairment and language barriers can be easily overlooked and left untreated and could lead to severe adverse outcomes. Accurate diagnosis is crucial, as PMR is readily diagnosed, but the treatment with glucocorticoids, though generally straightforward, can pose challenges, particularly when dealing with polypharmacy and multiple coexisting health conditions.

show abstract

Recommendations of the French Society of Rheumatology for the management in current practice of patients with polymyalgia rheumatica

Wendling,

Al Tabaa,

Chevet

et al. 2024

Joint Bone Spine

View full text Add to dashboard Cite

Why is polymyalgia rheumatica a disease of older adults? Explanations through etiology and pathogenesis: a narrative review

Cited by 7 publications

References 79 publications

Why would immuno- and endocrino-senescence, age-related changes in the gut microbiota, and susceptibility to infection favour polymyalgia rheumatica over seronegative elderly-onset rheumatoid arthritis?

Why would immuno- and endocrino-senescence, age-related changes in the gut microbiota, and susceptibility to infection favour polymyalgia rheumatica over seronegative elderly-onset rheumatoid arthritis?

Case Report and Literature Review of an Atypical Polymyalgia Rheumatica and Its Management

Recommendations of the French Society of Rheumatology for the management in current practice of patients with polymyalgia rheumatica

Contact Info

Product

Resources

About