Why Make Monofilament Sutures Out of Polyvinylidene Fluoride?

Urban, Elisabeth; King, Martin W.; Guidoin, Robert; Laroche, Gaétan; Marois, Yves; Martin, Louisette; Cardou, A.; Douville, Yvan

doi:10.1097/00002480-199404000-00006

Cited by 59 publications

(53 citation statements)

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“…3,4 In surgery, processed PVDF is being considered as a valuable alternative to the polypropylene monofilament suture. The medical grade PVDF has been shown to exhibit an excellent biocompatibility, with low cellular and tissue response 5 and outstanding in vitro biostability. When exposed to hydrolysis, PVDF loses 7.5% of its tensile strength over a 9-year period compared to 47% in the case of the polypropylene suture.…”

Section: Introductionmentioning

confidence: 99%

Identification and quantification of the crystalline structures of poly(vinylidene fluoride) sutures by wide-angle X-ray scattering and differential scanning calorimetry

Laroche

Lafrance

Prud’homme

et al. 1998

J. Biomed. Mater. Res.

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The outstanding biocompatibility of the polyvinylidene fluoride (PVDF) monofilament suture together with other desirable characteristics, such as ease of handling and resistance to biodegradation, makes it an attractive alternative monofilament suture material for cardiovascular surgery. However, to achieve a high performance suture, the polymeric raw material must be exposed to different treatments, which lead to different degrees and types of crystallization. Since these crystalline modifications deeply influence the mechanical characteristics and the biostability of the sutures, the authors hereby propose a method of quantifying the different structures of PVDF using wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC). The commercial devices are achieved by coloring and processing the polymeric raw material. The white and unprocessed 4-0 unswaged suture presents 19% of the alpha phase, 38% of the beta structure, and no gamma form. Coloration increases the amount of the beta phase by 5-9% at the expense of the alpha phase. On the other hand, processing the fibers lead to the conversion of some of the amorphous phase to the gamma structure, the importance of which is 6-7%. Finally, tensile measurements performed on the different PVDF fibers clearly proves that their mechanical characteristics depend on the presence of these crystalline forms in the polymeric structure of PVDF.

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Section: Introductionmentioning

confidence: 99%

Identification and quantification of the crystalline structures of poly(vinylidene fluoride) sutures by wide-angle X-ray scattering and differential scanning calorimetry

Laroche

Lafrance

Prud’homme

et al. 1998

J. Biomed. Mater. Res.

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“…Polyvinylidene fluoride (PVDF) is a polymer with improved textile and biological properties [19,20]. In comparison to other materials like polyethylene-terephtalat (PET), PVDF is more resistant to hydrolysis and degradation.…”

Section: Discussionmentioning

confidence: 99%

Transvaginal PVDF-mesh for cystocele repair: A cohort study

Barski

Arndt

Gerullis

et al. 2017

International Journal of Surgery

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h i g h l i g h t sPVDF-mesh is feasible for transvaginal application for cystocele repair. 15% of patients presented any kind of complications and 8.8% needed a resurgery for SUI or POP during the follow-up. Improvement of quality of life was reported by 87.5% according the PGI-I. The preliminary results support the initiation of prospective trial and registry according to IDEAL. a r t i c l e i n f o Results: 34 women were eligible for a mean follow up of 19 months. The functional outcome improved significantly. One symptomatic vault prolapse (2.9%) and two reoperations for incontinence (5.9%) occurred. Two mesh exposures (5.9%) occurred and were treated conservatively. No other severe complications were registered. 87.5% of treated women felt very much better or much better and would undergo the surgery again. A cohort study including development steps in accordance with the IDEAL system is presented. Conclusions: For the first time we report on effectivity and safety of transvaginal application of PVDFmesh in real-life practice. A prospective long-term evaluation in a registry is justified.

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“…PVDF is a non-absorbable fluoropolymer consisting of alternating methylene and difluoromethylene groups. This polymer shows improved textile and biological properties [85,86]. It is thermally stable and more resistant to abrasion than other fluoroplastics.…”

Section: Biomaterials Compositionmentioning

confidence: 99%

Mesh biocompatibility: effects of cellular inflammation and tissue remodelling

Junge

Binnebösel

Trotha

et al. 2011

Langenbecks Arch Surg

128

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Mesh biocompatibility is basically determined by the foreign body reaction (FBR). In contrast to physiological wound healing and scar formation, the FBR at the host-tissue/biomaterial interface is present for the lifetime of the medical device. The cellular interactions at the mesh/tissue interface proceed over time ending up in a chronic inflammatory process. The time course of the FBR has been studied extensively and consists of three crucial steps that are protein absorption, cell recruitment and, finally, fibrotic encapsulation and extracellular matrix formation. Each of these steps involves a complex cascade of immune modulators including soluble mediators and various cell types. Recent research has focused on the cellular and molecular interactions of the distinct phases of the FBR offering a new basis for therapeutical strategies. The highly dynamic process of the FBR is considerably influenced by the biomaterial composition. Modifications of the type of polymer, the material weight, the filament structure and the pore size are realized and have substantial effects on the in vivo biocompatibility. Moreover, modern mesh technology aims to utilize the available implants as carrier systems for bioactive drugs. Studies in animal models account for the efficiency of these drugs that aim to reduce mesh-related infections or to minimize FBR by influencing inflammation or extracellular matrix remodelling. A thorough understanding of the molecular mechanisms of FBR provides a sophisticated background for the development of new biomaterials at least as carrier systems for bioactive reagents to reduce inflammation and to improve clinical outcome.

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Why Make Monofilament Sutures Out of Polyvinylidene Fluoride?

Cited by 59 publications

References 0 publications

Identification and quantification of the crystalline structures of poly(vinylidene fluoride) sutures by wide-angle X-ray scattering and differential scanning calorimetry

Identification and quantification of the crystalline structures of poly(vinylidene fluoride) sutures by wide-angle X-ray scattering and differential scanning calorimetry

Transvaginal PVDF-mesh for cystocele repair: A cohort study

Mesh biocompatibility: effects of cellular inflammation and tissue remodelling

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