This case study presents and analyses Local Economic Development (LED) initiatives and challenges from two districts in Ghana. The study is a qualitative case study that uses individual interviews through purposive selection from officials who are directly involved in the formulation and implementation of district development initiatives. The study found that the district does not have a LED policy in place but have initiated and implemented a number of programmes that are pro-LED. These programmes are in the area of agriculture, human resource development, financing and infrastructure development. However, the implementation of these initiatives has encountered many challenges such as inadequate human resource, finance, absence of LED policy and improper collaboration among local level actors. The paper provides the way forward for the initiation and implementation of LED at the local level.