Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review

Itro, A; Trotta, Maria Consiglia; Miranda, Roberta; Paoletta, Marco; Cicco, Annalisa De; Lepre, Caterina Claudia; Tarantino, Umberto; D’Amico, Michele; Toro, Giuseppe; Panni, Alfredo Schiavone

doi:10.3390/pharmaceutics14061151

Cited by 8 publications

(11 citation statements)

References 65 publications

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“…Another cell therapy that has been used in the treatment of tendinopathies is the use of mesenchymal stem/stromal cells (MSC) from a variety of tissue sources including bone marrow, adipose tissue, and other sources including both allogeneic as well as autologous sources. Such studies have been recently reviewed extensively (61)(62)(63)(64)(65)(66)(67). As reviewed by Di Matteo et al (61) and Mirghaderi et al ( 65), often such MSC preparations are used in conjunction with PRP.…”

Section: Biologics and Tendinopathiesmentioning

confidence: 99%

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Hart

Ahmed²,

Ackermann³

2023

Front. Sports Act. Living

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Tendons are dense connective tissues of the musculoskeletal system that link bones with muscles to foster mobility. They have complex structures and exist in varying biomechanical, metabolic and biological environments. In addition, tendon composition and mechanical properties can change over the lifespan as an individual ages. Many tendons function in high stress conditions with a low vascular and neuronal supply, conditions often leading to development of chronic tendinopathies, and in some cases, overt rupture of the tissues. Given their essential nature for human mobility and navigation through the environment, the effective repair and regeneration of different tendons after injury or damage is critical for quality of life, and for elite athletes, the return to sport participation at a high level. However, for mainly unknown reasons, the outcomes following injury are not always successful and lead to functional compromise and risk for re-injury. Thus, there is a need to identify those patients who are at risk for developing tendon problems, as well those at risk for poor outcomes after injury and to design interventions to improve outcomes after injury or rupture to specific tendons. This review will discuss recent advances in the identification of biomarkers prognostic for successful and less successful outcomes after tendon injury, and the mechanistic implications of such biomarkers, as well as the potential for specific biologic interventions to enhance outcomes to improve both quality of life and a return to participation in sports. In addition, the implication of these biomarkers for clinical trial design is discussed, as is the issue of whether such biomarkers for successful healing of one tendon can be extended to all tendons or are valid only for tendons in specific biomechanical and biological environments. As maintaining an active lifestyle is critical for health, the successful implementation of these advances will benefit the large number of individuals at risk.

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Section: Biologics and Tendinopathiesmentioning

confidence: 99%

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Hart

Ahmed²,

Ackermann³

2023

Front. Sports Act. Living

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“… 2 Tendinopathy can also occur in some people due to age, obesity, chronic smoking, alcohol abuse, and the use of glucocorticoids for prolonged periods due to illness or work that puts the tendons under excessive strain. 3 , 4 , 5 In recent years, epidemiological studies have revealed that tendinopathy is increasingly prevalent in both sports medicine and orthopaedic clinical settings, resulting in substantial medical costs and disability. 4 , 6 …”

Section: Introductionmentioning

confidence: 99%

Advances in mesenchymal stem cells therapy for tendinopathies

Mao,

Zhang,

Yao

et al. 2024

Chinese Journal of Traumatology

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“…These are characterized by both micro- and macro-structural tendon alterations, leading to prolonged mechanical pain. 1 – 4 …”

Section: Introductionmentioning

confidence: 99%

Effects of adipose-derived mesenchymal stem cell conditioned medium on human tenocytes exposed to high glucose

Trotta,

Itro,

Lepre

et al. 2024

Therapeutic Advances in Musculoskeletal

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Introduction: Diabetic tendinopathy is a common invalidating and challenging disease that may be treated using stem cells. However, the effects of adipose-derived mesenchymal stem cell conditioned medium (ASC-CM) in diabetic tendinopathy have never been explored. Objectives: The present study evaluated the effects of ASC-CM on morphology, cell viability, structure, and scratch wound closure of human tenocytes (HTNC) exposed to high glucose (HG). Design: Experimental study. Methods: HTNC were exposed to HG (25 mM) for 7, 14 and 21 days with or without ASC-CM for the last 24 h. CM was collected from 4 × 105 ASCs, centrifuged for 10 min at 200 g and sterilized with 0.22 μm syringe filter. Results: At 7 days, HG-HTNC had decreased cell viability [72 ± 2%, p < 0.01 versus normal glucose (NG)] compared to NG-HTNC (90 ± 5%). A further decrement was detected after 14 and 21 days (60 ± 4% and 60 ± 5%, both, p < 0.01 versus NG and p < 0.01 versus HG7). While NG-HTNC evidenced a normal fibroblast cell-like elongated morphology, HG-HTNC showed increased cell roundness. In contrast, HG-HTNC exposed to ASC-CM showed a significant increase in cell viability, an improved cell morphology and higher scratch wound closure at all HG time points. Moreover, the exposure to ASC-CM significantly increased thrombospondin 1 and transforming growth factor beta 1 (TGF-β1) content in HG-HTNC. The TGF-β1 elevation was paralleled by higher Collagen I and Vascular Endothelial Growth Factor in HG-HTNC. Conclusion: ASC-CM may restore the natural morphology, cell viability and structure of HTNC, promoting their scratch wound closure through TGF-β1 increase.

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Why Use Adipose-Derived Mesenchymal Stem Cells in Tendinopathic Patients: A Systematic Review

Cited by 8 publications

References 65 publications

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Optimizing repair of tendon ruptures and chronic tendinopathies: Integrating the use of biomarkers with biological interventions to improve patient outcomes and clinical trial design

Advances in mesenchymal stem cells therapy for tendinopathies

Effects of adipose-derived mesenchymal stem cell conditioned medium on human tenocytes exposed to high glucose

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